In leukemic cells, glucose transport is activated by SCF and H2O2 through a common signal cascade involving Akt, PLCγ, Syk, and the Src family, in this order. An explanation can be provided by the phosphorylation of c-kit, the SCF receptor, elicited by either SCF or H2O2. Moreover, antioxidants prevent the SCF effect on glucose transport, confirming the involvement of H2O2 in the pathway leading to glucose-transport activation and suggesting a potential role for reactive oxygen species in leukemia proliferation.
GLUCOSE TRANSPORT ACTIVATION IN HUMAN HEMATOPOIETIC CELLS M07e IS MODULATED BY CYTOSOLIC CALCIUM AND CALMODULIN / MARALDI T.; RUGOLO M.; FIORENTINI D.; LANDI L.; HAKIM G.. - In: CELL CALCIUM. - ISSN 0142-8020. - STAMPA. - 40:(2006), pp. 373-381. [10.1016/j.ceca.2006.04.006]
GLUCOSE TRANSPORT ACTIVATION IN HUMAN HEMATOPOIETIC CELLS M07e IS MODULATED BY CYTOSOLIC CALCIUM AND CALMODULIN
RUGOLO, MICHELA;FIORENTINI, DIANA;LANDI, LAURA;HAKIM, GABRIELE
2006
Abstract
In leukemic cells, glucose transport is activated by SCF and H2O2 through a common signal cascade involving Akt, PLCγ, Syk, and the Src family, in this order. An explanation can be provided by the phosphorylation of c-kit, the SCF receptor, elicited by either SCF or H2O2. Moreover, antioxidants prevent the SCF effect on glucose transport, confirming the involvement of H2O2 in the pathway leading to glucose-transport activation and suggesting a potential role for reactive oxygen species in leukemia proliferation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
