In leukemic cells, glucose transport is activated by SCF and H2O2 through a common signal cascade involving Akt, PLCγ, Syk, and the Src family, in this order. An explanation can be provided by the phosphorylation of c-kit, the SCF receptor, elicited by either SCF or H2O2. Moreover, antioxidants prevent the SCF effect on glucose transport, confirming the involvement of H2O2 in the pathway leading to glucose-transport activation and suggesting a potential role for reactive oxygen species in leukemia proliferation.

GLUCOSE TRANSPORT ACTIVATION IN HUMAN HEMATOPOIETIC CELLS M07e IS MODULATED BY CYTOSOLIC CALCIUM AND CALMODULIN

RUGOLO, MICHELA;FIORENTINI, DIANA;LANDI, LAURA;HAKIM, GABRIELE
2006

Abstract

In leukemic cells, glucose transport is activated by SCF and H2O2 through a common signal cascade involving Akt, PLCγ, Syk, and the Src family, in this order. An explanation can be provided by the phosphorylation of c-kit, the SCF receptor, elicited by either SCF or H2O2. Moreover, antioxidants prevent the SCF effect on glucose transport, confirming the involvement of H2O2 in the pathway leading to glucose-transport activation and suggesting a potential role for reactive oxygen species in leukemia proliferation.
CELL CALCIUM
MARALDI T.; RUGOLO M.; FIORENTINI D.; LANDI L.; HAKIM G.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/28902
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