In leukemic cells, glucose transport is activated by SCF and H2O2 through a common signal cascade involving Akt, PLCγ, Syk, and the Src family, in this order. An explanation can be provided by the phosphorylation of c-kit, the SCF receptor, elicited by either SCF or H2O2. Moreover, antioxidants prevent the SCF effect on glucose transport, confirming the involvement of H2O2 in the pathway leading to glucose-transport activation and suggesting a potential role for reactive oxygen species in leukemia proliferation.
MARALDI T., RUGOLO M., FIORENTINI D., LANDI L., HAKIM G. (2006). GLUCOSE TRANSPORT ACTIVATION IN HUMAN HEMATOPOIETIC CELLS M07e IS MODULATED BY CYTOSOLIC CALCIUM AND CALMODULIN. CELL CALCIUM, 40, 373-381 [10.1016/j.ceca.2006.04.006].
GLUCOSE TRANSPORT ACTIVATION IN HUMAN HEMATOPOIETIC CELLS M07e IS MODULATED BY CYTOSOLIC CALCIUM AND CALMODULIN
RUGOLO, MICHELA;FIORENTINI, DIANA;LANDI, LAURA;HAKIM, GABRIELE
2006
Abstract
In leukemic cells, glucose transport is activated by SCF and H2O2 through a common signal cascade involving Akt, PLCγ, Syk, and the Src family, in this order. An explanation can be provided by the phosphorylation of c-kit, the SCF receptor, elicited by either SCF or H2O2. Moreover, antioxidants prevent the SCF effect on glucose transport, confirming the involvement of H2O2 in the pathway leading to glucose-transport activation and suggesting a potential role for reactive oxygen species in leukemia proliferation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
