Glycogen synthase kinase-3 (GSK-3) is a critical enzyme which participates in a complex array of important cellular processes and is often involved in various human diseases. It was first characterized in rat skeletal muscle as a serine/threonine (S/T) kinase that phosphorylated and inactivated glycogen synthase (GS). GS is the last enzyme in glycogen biosynthesis . Thus the initially identified role of GSK-3 was in metabolism. However, as we will soon see, GSK-3 has many diverse functions.
J.A. McCubrey, N.M. Davis, S.L. Abrams, G. Montalto, M. Cervello, J. Basecke, et al. (2014). Diverse roles of GSK-3: Tumor promoter-tumor suppressor, target in cancer therapy. ADVANCES IN BIOLOGICAL REGULATION, 54, 176-196 [10.1016/j.jbior.2013.09.013.].
Diverse roles of GSK-3: Tumor promoter-tumor suppressor, target in cancer therapy.
COCCO, LUCIO ILDEBRANDO;MARTELLI, ALBERTO MARIA;
2014
Abstract
Glycogen synthase kinase-3 (GSK-3) is a critical enzyme which participates in a complex array of important cellular processes and is often involved in various human diseases. It was first characterized in rat skeletal muscle as a serine/threonine (S/T) kinase that phosphorylated and inactivated glycogen synthase (GS). GS is the last enzyme in glycogen biosynthesis . Thus the initially identified role of GSK-3 was in metabolism. However, as we will soon see, GSK-3 has many diverse functions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
