A consistent rate of patients who are classified as “node-negative” after radical prostatectomy and pelvic lymph-node dissection (PLND) experience a nodal disease relapse. Routine pathological examination can miss micro-metastatic tumor foci in the lymph nodes (LN) of patients with prostate cancer (PCa), resulting in confused tumor staging and clinical decision-making. The aim of the present perspective study was to evaluate the impact of micro-metastasis assessed by serial section (SS), immunohistochemistry (IHC) and real time-Polymerase Chain Reaction (RT-PCR) in patient submitted to radical prostatectomy with extended PLND.
Titolo: | Detection of nodal micro metastases with serial section, immunohistochemistry and real time-polymerase chain reaction in intermediate and high risk prostate cancer patients submitted to radical prostatectomy with extended pelvic lymph node dissection: A perspective study |
Autore/i: | SCHIAVINA, RICCARDO; ROMAGNOLI, DANIELE; BORGHESI, MARCO; ROCCA C.; ZUKERMAN, ZIV; SAVINI, ANDREA; DABABNEH, HUSSAM; BARBIERI, BARBARA; BRUNOCILLA, EUGENIO; MANFERRARI, FABIO; MARTORANA, GIUSEPPE |
Autore/i Unibo: | |
Anno: | 2012 |
Rivista: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S1569-9056(12)60120-1 |
Abstract: | A consistent rate of patients who are classified as “node-negative” after radical prostatectomy and pelvic lymph-node dissection (PLND) experience a nodal disease relapse. Routine pathological examination can miss micro-metastatic tumor foci in the lymph nodes (LN) of patients with prostate cancer (PCa), resulting in confused tumor staging and clinical decision-making. The aim of the present perspective study was to evaluate the impact of micro-metastasis assessed by serial section (SS), immunohistochemistry (IHC) and real time-Polymerase Chain Reaction (RT-PCR) in patient submitted to radical prostatectomy with extended PLND. |
Data prodotto definitivo in UGOV: | 2014-03-24 17:00:47 |
Appare nelle tipologie: | 1.01 Articolo in rivista |