A consistent rate of patients who are classified as “node-negative” after radical prostatectomy and pelvic lymph-node dissection (PLND) experience a nodal disease relapse. Routine pathological examination can miss micro-metastatic tumor foci in the lymph nodes (LN) of patients with prostate cancer (PCa), resulting in confused tumor staging and clinical decision-making. The aim of the present perspective study was to evaluate the impact of micro-metastasis assessed by serial section (SS), immunohistochemistry (IHC) and real time-Polymerase Chain Reaction (RT-PCR) in patient submitted to radical prostatectomy with extended PLND.
Detection of nodal micro metastases with serial section, immunohistochemistry and real time-polymerase chain reaction in intermediate and high risk prostate cancer patients submitted to radical prostatectomy with extended pelvic lymph node dissection: A perspective study / SCHIAVINA R.;ROMAGNOLI D.;BORGHESI M.;ROCCA C.;ZUCKERMAN Z.;SAVINI A.;DABABNEH H.;BARBIERI B.;BRUNOCILLA E.;MANFERRARI F.;MARTORANA G.. - In: EUROPEAN UROLOGY. SUPPLEMENTS. - ISSN 1569-9056. - ELETTRONICO. - 10:(2012), pp. 121-121. [10.1016/S1569-9056(12)60120-1]
Detection of nodal micro metastases with serial section, immunohistochemistry and real time-polymerase chain reaction in intermediate and high risk prostate cancer patients submitted to radical prostatectomy with extended pelvic lymph node dissection: A perspective study
SCHIAVINA, RICCARDO;ROMAGNOLI, DANIELE;BORGHESI, MARCO;ZUKERMAN, ZIV;SAVINI, ANDREA;DABABNEH, HUSSAM;BARBIERI, BARBARA;BRUNOCILLA, EUGENIO;MANFERRARI, FABIO;MARTORANA, GIUSEPPE
2012
Abstract
A consistent rate of patients who are classified as “node-negative” after radical prostatectomy and pelvic lymph-node dissection (PLND) experience a nodal disease relapse. Routine pathological examination can miss micro-metastatic tumor foci in the lymph nodes (LN) of patients with prostate cancer (PCa), resulting in confused tumor staging and clinical decision-making. The aim of the present perspective study was to evaluate the impact of micro-metastasis assessed by serial section (SS), immunohistochemistry (IHC) and real time-Polymerase Chain Reaction (RT-PCR) in patient submitted to radical prostatectomy with extended PLND.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.