A consistent rate of patients who are classified as “node-negative” after radical prostatectomy and pelvic lymph-node dissection (PLND) experience a nodal disease relapse. Routine pathological examination can miss micro-metastatic tumor foci in the lymph nodes (LN) of patients with prostate cancer (PCa), resulting in confused tumor staging and clinical decision-making. The aim of the present perspective study was to evaluate the impact of micro-metastasis assessed by serial section (SS), immunohistochemistry (IHC) and real time-Polymerase Chain Reaction (RT-PCR) in patient submitted to radical prostatectomy with extended PLND.

Detection of nodal micro metastases with serial section, immunohistochemistry and real time-polymerase chain reaction in intermediate and high risk prostate cancer patients submitted to radical prostatectomy with extended pelvic lymph node dissection: A perspective study

SCHIAVINA, RICCARDO;ROMAGNOLI, DANIELE;BORGHESI, MARCO;ZUKERMAN, ZIV;SAVINI, ANDREA;DABABNEH, HUSSAM;BARBIERI, BARBARA;BRUNOCILLA, EUGENIO;MANFERRARI, FABIO;MARTORANA, GIUSEPPE
2012

Abstract

A consistent rate of patients who are classified as “node-negative” after radical prostatectomy and pelvic lymph-node dissection (PLND) experience a nodal disease relapse. Routine pathological examination can miss micro-metastatic tumor foci in the lymph nodes (LN) of patients with prostate cancer (PCa), resulting in confused tumor staging and clinical decision-making. The aim of the present perspective study was to evaluate the impact of micro-metastasis assessed by serial section (SS), immunohistochemistry (IHC) and real time-Polymerase Chain Reaction (RT-PCR) in patient submitted to radical prostatectomy with extended PLND.
SCHIAVINA R.;ROMAGNOLI D.;BORGHESI M.;ROCCA C.;ZUCKERMAN Z.;SAVINI A.;DABABNEH H.;BARBIERI B.;BRUNOCILLA E.;MANFERRARI F.;MARTORANA G.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/257834
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