BACKGROUND: "in vivo" application of a new echographic method able to better identify neoplastic tissue. The aim of this study was to evaluate its accuracy in the diagnosis of prostate cancer. MATERIALS AND METHODS: Double-blind prospective study on 60 patients (pts) submitted to both transrectal ultrasound (TRUS) of prostate with a traditional echograph connected to a new hardware/software platform named FEMMINA (Fast Echographic Multiparameter Multi Image Novel Apparatus) that processes the echo signal by RULES (Radiofrequency Ultrasonic Local EStimators) algorithm and to a prostatic biopsy (8 to 12 cores). Histological findings of biopsies were compared to B-mode and the new ultrasound method. RESULTS: Cancer was detected in 18/60 pts. 14 patients had positive images with RULES, 11 with B-mode modality. The positive predictive value (PPV) and negative predictive value (NPV) of B-mode were 42% and 79% while 77% and 90% of RULES. Sensitivity and specificity of B-mode were 61% and 79% while those of RULES were 77% and 90%. B-mode diagnostic accuracy was 63% and RULES accuracy was 86%. CONCLUSIONS: Results obtained with RULES are encouraging but they need further studies for its application in clinical practice.

A novel spectral ultrasonic differentiation method for marking regions of interest in biological tissues. In vivo preliminary results.

BERTACCINI, ALESSANDRO;FRANCESCHELLI, ALESSANDRO;SCHIAVINA, RICCARDO;MANFERRARI, FABIO;BRUNOCILLA, EUGENIO;BACCOS, ALESSANDRO;MARTORANA, GIUSEPPE
2007

Abstract

BACKGROUND: "in vivo" application of a new echographic method able to better identify neoplastic tissue. The aim of this study was to evaluate its accuracy in the diagnosis of prostate cancer. MATERIALS AND METHODS: Double-blind prospective study on 60 patients (pts) submitted to both transrectal ultrasound (TRUS) of prostate with a traditional echograph connected to a new hardware/software platform named FEMMINA (Fast Echographic Multiparameter Multi Image Novel Apparatus) that processes the echo signal by RULES (Radiofrequency Ultrasonic Local EStimators) algorithm and to a prostatic biopsy (8 to 12 cores). Histological findings of biopsies were compared to B-mode and the new ultrasound method. RESULTS: Cancer was detected in 18/60 pts. 14 patients had positive images with RULES, 11 with B-mode modality. The positive predictive value (PPV) and negative predictive value (NPV) of B-mode were 42% and 79% while 77% and 90% of RULES. Sensitivity and specificity of B-mode were 61% and 79% while those of RULES were 77% and 90%. B-mode diagnostic accuracy was 63% and RULES accuracy was 86%. CONCLUSIONS: Results obtained with RULES are encouraging but they need further studies for its application in clinical practice.
BERTACCINI A;FRANCESCHELLI A;SCHIAVINA R;MANFERRARI F;BRUNOCILLA E.;MARCHIORI D;BACCOS A;GRANCHI S;BIAGI E;MASOTTI L;MARTORANA G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/257751
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