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EnglishBACKGROUND: "in vivo" application of a new echographic method able to better identify neoplastic tissue. The aim of this study was to evaluate its accuracy in the diagnosis of prostate cancer. MATERIALS AND METHODS: Double-blind prospective study on 60 patients (pts) submitted to both transrectal ultrasound (TRUS) of prostate with a traditional echograph connected to a new hardware/software platform named FEMMINA (Fast Echographic Multiparameter Multi Image Novel Apparatus) that processes the echo signal by RULES (Radiofrequency Ultrasonic Local EStimators) algorithm and to a prostatic biopsy (8 to 12 cores). Histological findings of biopsies were compared to B-mode and the new ultrasound method. RESULTS: Cancer was detected in 18/60 pts. 14 patients had positive images with RULES, 11 with B-mode modality. The positive predictive value (PPV) and negative predictive value (NPV) of B-mode were 42% and 79% while 77% and 90% of RULES. Sensitivity and specificity of B-mode were 61% and 79% while those of RULES were 77% and 90%. B-mode diagnostic accuracy was 63% and RULES accuracy was 86%. CONCLUSIONS: Results obtained with RULES are encouraging but they need further studies for its application in clinical practice.
| Titolo: | A novel spectral ultrasonic differentiation method for marking regions of interest in biological tissues. In vivo preliminary results. |
| Autore/i: | BERTACCINI, ALESSANDRO; FRANCESCHELLI, ALESSANDRO; SCHIAVINA, RICCARDO; MANFERRARI, FABIO; BRUNOCILLA, EUGENIO; MARCHIORI D; BACCOS, ALESSANDRO; GRANCHI S; BIAGI E; MASOTTI L; MARTORANA, GIUSEPPE |
| Autore/i Unibo: | |
| Anno: | 2007 |
| Rivista: | |
| Abstract: | BACKGROUND: "in vivo" application of a new echographic method able to better identify neoplastic tissue. The aim of this study was to evaluate its accuracy in the diagnosis of prostate cancer. MATERIALS AND METHODS: Double-blind prospective study on 60 patients (pts) submitted to both transrectal ultrasound (TRUS) of prostate with a traditional echograph connected to a new hardware/software platform named FEMMINA (Fast Echographic Multiparameter Multi Image Novel Apparatus) that processes the echo signal by RULES (Radiofrequency Ultrasonic Local EStimators) algorithm and to a prostatic biopsy (8 to 12 cores). Histological findings of biopsies were compared to B-mode and the new ultrasound method. RESULTS: Cancer was detected in 18/60 pts. 14 patients had positive images with RULES, 11 with B-mode modality. The positive predictive value (PPV) and negative predictive value (NPV) of B-mode were 42% and 79% while 77% and 90% of RULES. Sensitivity and specificity of B-mode were 61% and 79% while those of RULES were 77% and 90%. B-mode diagnostic accuracy was 63% and RULES accuracy was 86%. CONCLUSIONS: Results obtained with RULES are encouraging but they need further studies for its application in clinical practice. |
| Data prodotto definitivo in UGOV: | 2014-03-25 13:42:42 |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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http://hdl.handle.net/11585/257751
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