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EnglishAs centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metabolome and lipidome composition of a group of centenarians with respect to elderly individuals. Specifically, NMR metabonomics profiling of serum revealed that centenarians are characterized by a metabolic phenotype distinct from that of elderly subjects, in particular regarding amino acids and lipid species. Shot- gun lipidomics approach displays unique changes in lipids biosynthesis in centenarians, with 41 differently abundant lipid species with respect to elderly subjects. These findings reveal phospho/sphingolipids as putative markers and biological modulators of healthy aging, in humans. Considering the particular actions of these metabolites, these data are suggestive of a better counteractive antioxidant capacity and a well-developed membrane lipid remodelling process in the healthy aging phenotype.
| Titolo: | Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity. |
| Autore/i: | Montoliu I.; Scherer M.; Beguelin F.; Dasilva L.; Mari D.; SALVIOLI, STEFANO; Martin F. P.; CAPRI, MIRIAM; BUCCI, LAURA; OSTAN, RITA; GARAGNANI, PAOLO; Monti D.; BIAGI, ELENA; BRIGIDI, PATRIZIA; Kussmann M.; Rezzi S.; FRANCESCHI, CLAUDIO; Collino S. |
| Autore/i Unibo: | |
| Anno: | 2014 |
| Rivista: | |
| Abstract: | As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metabolome and lipidome composition of a group of centenarians with respect to elderly individuals. Specifically, NMR metabonomics profiling of serum revealed that centenarians are characterized by a metabolic phenotype distinct from that of elderly subjects, in particular regarding amino acids and lipid species. Shot- gun lipidomics approach displays unique changes in lipids biosynthesis in centenarians, with 41 differently abundant lipid species with respect to elderly subjects. These findings reveal phospho/sphingolipids as putative markers and biological modulators of healthy aging, in humans. Considering the particular actions of these metabolites, these data are suggestive of a better counteractive antioxidant capacity and a well-developed membrane lipid remodelling process in the healthy aging phenotype. |
| Data prodotto definitivo in UGOV: | 2014-03-13 18:58:04 |
| Data stato definitivo: | 2020-02-27T17:09:17Z |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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