CAPRI, MIRIAM
CAPRI, MIRIAM
DIMEC - DIPARTIMENTO DI SCIENZE MEDICHE E CHIRURGICHE
Docenti di ruolo di IIa fascia
M. CAPRI; Miriam Capri; CAPRI M
Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population
2025 Giacconi, Robertina; Pirazzini, Chiara; Bacalini, Maria Giulia; Garagnani, Paolo; Capri, Miriam; Franceschi, Claudio; Fortunato, Carlo; Pazmay, Gretta Veronica Badillo; Bürkle, Alexander; Villanueva, María Moreno; Cardelli, Maurizio; Piacenza, Francesco; Cecati, Monia; Cianfruglia, Laura; Dollé, Martijn E. T.; Jansen, Eugène; Grune, Tilman; Gonos, Efstathios S.; Weinberger, Birgit; Sikora, Ewa; Zampieri, Michele; Caiafa, Paola; Ciccarone, Fabio; Reale, Anna; Debacq-Chainiaux, Florence; Stuetz, Wolfgang; Hurme, Mikko; Slagboom, P. Eline; Bernhardt, Jürgen; Olivieri, Fabiola; Malavolta, Marco
Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort
2024 Schoissengeier V.; Maqboul L.; Weber D.; Grune T.; Bürkle A.; Moreno-Villaneuva M.; Franceschi C.; Capri M.; Bernhard J.; Toussaint O.; Debacq-Chainiaux F.; Weinberger B.; Gonos E.S.; Sikora E.; Dollé M.; Jansen E.; Slagboom P.E.; Hervonnen A.; Hurme M.; Breusing N.; Frank J.; Bulmer A.C.; Wagner K.H.
Circulating CXCL9, monocyte percentage, albumin, and C-reactive protein as a potential, non-invasive, molecular signature of carotid artery disease in 65+ patients with multimorbidity: a pilot study in Age.It
2024 Capri M.; Fronterre S.; Collura S.; Giampieri E.; Carrino S.; Feroldi F.M.; Ciurca E.; Conte M.; Olivieri F.; Ullo I.; Pini R.; Vacirca A.; Astolfi A.; Vasuri F.; La Manna G.; Pasquinelli G.; Gargiulo M.
Detection of HHV-5 HHV-6a HHV-6b and HHV-7 in the urine: potential use as a non-invasive diagnostic tool for immune profiling
2024 Govind, S.; Lang, P. O.; Bürkle, A.; Moreno-Villanueva, M.; Franceschi, C.; Capri, M.; Bernard, J.; Weinberger, B.; Grubeck-Loebenstein, B.; Fiegl, S.; Gonos, E. S.; Sikora, E.; Jansen, E.; Dollé, M. E. T.; Grune, T.; Breusing, N.; Aspinall, R.
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data
2024 Valeanu, A; Margina, D; Weber, D; Stuetz, W; Moreno-Villanueva, M; Dollé, Met; Jansen, Eh; Gonos, Es; Bernhardt, J; Grubeck-Loebenstein, B; Weinberger, B; Fiegl, S; Sikora, E; Mosieniak, G; Toussaint, O; Debacq-Chainiaux, F; Capri, M; Garagnani, P; Pirazzini, C; Bacalini, Mg; Hervonen, A; Slagboom, Pe; Talbot, D; Breusing, N; Frank, J; Bürkle, A; Franceschi, C; Grune, T; Gradinaru, D.
Heterogeneity and Differentiation of the Human Arterial Tree: Focus on microRNA Expression in Vascular Disease
2024 Ciavarella C.; Motta I.; Capri M.; Gargiulo M.; Pasquinelli G.
Machine learning for precision diagnostics of autoimmunity
2024 Kruta, J.; Carapito, R.; Trendelenburg, M.; Martin, T.; Rizzi, M.; Voll, R. E.; Cavalli, A.; Natali, E.; Meier, P.; Stawiski, M.; Mosbacher, J.; Mollet, A.; Santoro, A.; Capri, M.; Giampieri, E.; Schkommodau, E.; Miho, E.
Physical performance strongly predicts all-cause mortality risk in a real-world population of older diabetic patients: machine learning approach for mortality risk stratification
2024 Alberto Montesanto, Vincenzo Lagani, Liana Spazzafumo, Elena Tortato, Sonia Rosati, Andrea Corsonello, Luca Soraci, Jacopo Sabbatinelli, Antonio Cherubini, Maria Conte, Miriam Capri, Maria Capalbo, Fabrizia Lattanzio, Fabiola Olivieri and Anna Rita Bonfigli
Association of Torquetenovirus Viremia with Physical Frailty and Cognitive Impairment in Three Independent European Cohorts
2023 Giacconi R.; Laffon B.; Costa S.; Teixeira-Gomes A.; Maggi F.; MacEra L.; Spezia P.G.; Piacenza F.; Burkle A.; Moreno-Villanueva M.; Bonassi S.; Valdiglesias V.; Teixeira J.P.; Dolle M.E.T.; Rietman M.L.; Jansen E.; Grune T.; Gonos E.S.; Franceschi C.; Capri M.; Weinberger B.; Sikora E.; Stuetz W.; Toussaint O.; Debacq-Chainiaux F.; Hervonen A.; Hurme M.; Slagboom P.E.; Schon C.; Bernhardt J.; Breusing N.; Pasaro E.; Maseda A.; Lorenzo-Lopez L.; Millan-Calenti J.C.; Provinciali M.; Malavolta M.
Bacterial DNAemia in Older Participants and Nonagenarian Offspring and Association With Redox Biomarkers: Results From MARK-AGE Study
2023 Giacconi R.; D'Aquila P.; Malavolta M.; Piacenza F.; Burkle A.; Villanueva M.M.; Dolle M.E.T.; Jansen E.; Grune T.; Gonos E.S.; Franceschi C.; Capri M.; Gradinaru D.; Grubeck-Loebenstein B.; Sikora E.; Stuetz W.; Weber D.; Toussaint O.; Debacq-Chainiaux F.; Hervonen A.; Hurme M.; Slagboom P.E.; Schon C.; Bernhardt J.; Breusing N.; Duncan T.; Passarino G.; Bellizzi D.; Provinciali M.
Biomarkers of aging in frailty and age-associated disorders: State of the art and future perspective
2023 Salvioli S.; Basile M.S.; Bencivenga L.; Carrino S.; Conte M.; Damanti S.; De Lorenzo R.; Fiorenzato E.; Gialluisi A.; Ingannato A.; Antonini A.; Baldini N.; Capri M.; Cenci S.; Iacoviello L.; Nacmias B.; Olivieri F.; Rengo G.; Querini P.R.; Lattanzio F.
Circulating miR-122-5p, miR-92a-3p, and miR-18a-5p as Potential Biomarkers in Human Liver Transplantation Follow-Up
2023 Morsiani C.; Collura S.; Sevini F.; Ciurca E.; Bertuzzo V.R.; Franceschi C.; Grazi G.L.; Cescon M.; Capri M.
Long-term human spaceflight and inflammaging: Does it promote aging?
2023 Miriam Capri, Maria Conte, Erika Ciurca, Chiara Pirazzini, Paolo Garagnani, Aurelia Santoro, Federica Longo, Stefano Salvioli, Patrick Lau, Ralf Moeller, Jens Jordan, Thomas Illig, Maria-Moreno Villanueva, Markus Gruber, Alexander Bürkle, Claudio Franceschi, Jörn Rittweger
The expression pattern of GDF15 in human brain changes during aging and in Alzheimer's disease
2023 Chiariello, Antonio; Valente, Sabrina; Pasquinelli, Gianandrea; Baracca, Alessandra; Sgarbi, Gianluca; Solaini, Giancarlo; Medici, Valentina; Fantini, Valentina; Poloni, Tino Emanuele; Tognocchi, Monica; Arcaro, Marina; Galimberti, Daniela; Franceschi, Claudio; Capri, Miriam; Salvioli, Stefano; Conte, Maria
Uncovering the Relationship between Selenium Status, Age, Health, and Dietary Habits: Insights from a Large Population Study including Nonagenarian Offspring from the MARK-AGE Project
2023 Giacconi R.; Piacenza F.; Aversano V.; Zampieri M.; Bürkle A.; Villanueva M.M.; Dollé M.E.T.; Jansen E.; Grune T.; Gonos E.S.; Franceschi C.; Capri M.; Weinberger B.; Sikora E.; Toussaint O.; Debacq-Chainiaux F.; Stuetz W.; Slagboom P.E.; Bernhardt J.; Fernández-Sánchez M.L.; Provinciali M.; Malavolta M.
A Targeted Epigenetic Clock for the Prediction of Biological Age
2022 Gensous, Noémie; Sala, Claudia; Pirazzini, Chiara; Ravaioli, Francesco; Milazzo, Maddalena; Kwiatkowska, Katarzyna Malgorzata; Marasco, Elena; De Fanti, Sara; Giuliani, Cristina; Pellegrini, Camilla; Santoro, Aurelia; Capri, Miriam; Salvioli, Stefano; Monti, Daniela; Castellani, Gastone; Franceschi, Claudio; Bacalini, Maria Giulia; Garagnani, Paolo
Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease
2022 de Eguileor M.; Grimaldi A.; Pulze L.; Acquati F.; Morsiani C.; Capri M.
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome
2022 Morsiani C.; Bacalini M.G.; Collura S.; Moreno-Villanueva M.; Breusing N.; Burkle A.; Grune T.; Franceschi C.; De Eguileor M.; Capri M.
Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics
2022 Kananen L.; Hurme M.; Burkle A.; Moreno-Villanueva M.; Bernhardt J.; Debacq-Chainiaux F.; Grubeck-Loebenstein B.; Malavolta M.; Basso A.; Piacenza F.; Collino S.; Gonos E.S.; Sikora E.; Gradinaru D.; Jansen E.H.J.M.; Dolle M.E.T.; Salmon M.; Stuetz W.; Weber D.; Grune T.; Breusing N.; Simm A.; Capri M.; Franceschi C.; Slagboom E.; Talbot D.; Libert C.; Raitanen J.; Koskinen S.; Harkanen T.; Stenholm S.; Ala-Korpela M.; Lehtimaki T.; Raitakari O.T.; Ukkola O.; Kahonen M.; Jylha M.; Jylhava J.
Current approaches of anti-age related diseases: From molecules up to whole organism
2022 Capri M.; Morsiani C.
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population | Giacconi, Robertina; Pirazzini, Chiara; Bacalini, Maria Giulia; Garagnani, Paolo; Capri, Miriam; ...Franceschi, Claudio; Fortunato, Carlo; Pazmay, Gretta Veronica Badillo; Bürkle, Alexander; Villanueva, María Moreno; Cardelli, Maurizio; Piacenza, Francesco; Cecati, Monia; Cianfruglia, Laura; Dollé, Martijn E. T.; Jansen, Eugène; Grune, Tilman; Gonos, Efstathios S.; Weinberger, Birgit; Sikora, Ewa; Zampieri, Michele; Caiafa, Paola; Ciccarone, Fabio; Reale, Anna; Debacq-Chainiaux, Florence; Stuetz, Wolfgang; Hurme, Mikko; Slagboom, P. Eline; Bernhardt, Jürgen; Olivieri, Fabiola; Malavolta, Marco | 2025-01-01 | MECHANISMS OF AGEING AND DEVELOPMENT | - | 1.01 Articolo in rivista | MAD-S-24-00667.pdf |
| Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort | Schoissengeier V.; Maqboul L.; Weber D.; Grune T.; Bürkle A.; Moreno-Villaneuva M.; Franceschi C....; Capri M.; Bernhard J.; Toussaint O.; Debacq-Chainiaux F.; Weinberger B.; Gonos E.S.; Sikora E.; Dollé M.; Jansen E.; Slagboom P.E.; Hervonnen A.; Hurme M.; Breusing N.; Frank J.; Bulmer A.C.; Wagner K.H. | 2024-01-01 | ISCIENCE | - | 1.01 Articolo in rivista | Schoissengeier_etal_iSceince24.pdf; supp_Tables.pdf |
| Circulating CXCL9, monocyte percentage, albumin, and C-reactive protein as a potential, non-invasive, molecular signature of carotid artery disease in 65+ patients with multimorbidity: a pilot study in Age.It | Capri M.; Fronterre S.; Collura S.; Giampieri E.; Carrino S.; Feroldi F.M.; Ciurca E.; Conte M.; ...Olivieri F.; Ullo I.; Pini R.; Vacirca A.; Astolfi A.; Vasuri F.; La Manna G.; Pasquinelli G.; Gargiulo M. | 2024-01-01 | FRONTIERS IN ENDOCRINOLOGY | - | 1.01 Articolo in rivista | Capri_etal_FrontiersEnd24.pdf |
| Detection of HHV-5 HHV-6a HHV-6b and HHV-7 in the urine: potential use as a non-invasive diagnostic tool for immune profiling | Govind, S.; Lang, P. O.; Bürkle, A.; Moreno-Villanueva, M.; Franceschi, C.; Capri, M.; Bernard, J....; Weinberger, B.; Grubeck-Loebenstein, B.; Fiegl, S.; Gonos, E. S.; Sikora, E.; Jansen, E.; Dollé, M. E. T.; Grune, T.; Breusing, N.; Aspinall, R. | 2024-01-01 | IMMUNITY & AGEING | - | 1.01 Articolo in rivista | Govind_etal_Immunity&Aging.pdf |
| Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data | Valeanu, A; Margina, D; Weber, D; Stuetz, W; Moreno-Villanueva, M; Dollé, Met; Jansen, Eh; Gonos,... Es; Bernhardt, J; Grubeck-Loebenstein, B; Weinberger, B; Fiegl, S; Sikora, E; Mosieniak, G; Toussaint, O; Debacq-Chainiaux, F; Capri, M; Garagnani, P; Pirazzini, C; Bacalini, Mg; Hervonen, A; Slagboom, Pe; Talbot, D; Breusing, N; Frank, J; Bürkle, A; Franceschi, C; Grune, T; Gradinaru, D. | 2024-01-01 | MECHANISMS OF AGEING AND DEVELOPMENT | - | 1.01 Articolo in rivista | 1-s2.0-S0047637424000873-main.pdf |
| Heterogeneity and Differentiation of the Human Arterial Tree: Focus on microRNA Expression in Vascular Disease | Ciavarella C.; Motta I.; Capri M.; Gargiulo M.; Pasquinelli G. | 2024-01-01 | BIOMOLECULES | - | 1.01 Articolo in rivista | biomolecules-14-00343-v2.pdf |
| Machine learning for precision diagnostics of autoimmunity | Kruta, J.; Carapito, R.; Trendelenburg, M.; Martin, T.; Rizzi, M.; Voll, R. E.; Cavalli, A.; Nata...li, E.; Meier, P.; Stawiski, M.; Mosbacher, J.; Mollet, A.; Santoro, A.; Capri, M.; Giampieri, E.; Schkommodau, E.; Miho, E. | 2024-01-01 | SCIENTIFIC REPORTS | - | 1.01 Articolo in rivista | Kruta et al_2024_Scient_rep_Machine_Learning.pdf; 41598_2024_76093_MOESM1_ESM.pdf |
| Physical performance strongly predicts all-cause mortality risk in a real-world population of older diabetic patients: machine learning approach for mortality risk stratification | Alberto Montesanto, Vincenzo Lagani, Liana Spazzafumo, Elena Tortato, Sonia Rosati, Andrea Corson...ello, Luca Soraci, Jacopo Sabbatinelli, Antonio Cherubini, Maria Conte, Miriam Capri, Maria Capalbo, Fabrizia Lattanzio, Fabiola Olivieri and Anna Rita Bonfigli | 2024-01-01 | FRONTIERS IN ENDOCRINOLOGY | - | 1.01 Articolo in rivista | - |
| Association of Torquetenovirus Viremia with Physical Frailty and Cognitive Impairment in Three Independent European Cohorts | Giacconi R.; Laffon B.; Costa S.; Teixeira-Gomes A.; Maggi F.; MacEra L.; Spezia P.G.; Piacenza F....; Burkle A.; Moreno-Villanueva M.; Bonassi S.; Valdiglesias V.; Teixeira J.P.; Dolle M.E.T.; Rietman M.L.; Jansen E.; Grune T.; Gonos E.S.; Franceschi C.; Capri M.; Weinberger B.; Sikora E.; Stuetz W.; Toussaint O.; Debacq-Chainiaux F.; Hervonen A.; Hurme M.; Slagboom P.E.; Schon C.; Bernhardt J.; Breusing N.; Pasaro E.; Maseda A.; Lorenzo-Lopez L.; Millan-Calenti J.C.; Provinciali M.; Malavolta M. | 2023-01-01 | GERONTOLOGY | - | 1.01 Articolo in rivista | Giacconi_Assoc.pdf |
| Bacterial DNAemia in Older Participants and Nonagenarian Offspring and Association With Redox Biomarkers: Results From MARK-AGE Study | Giacconi R.; D'Aquila P.; Malavolta M.; Piacenza F.; Burkle A.; Villanueva M.M.; Dolle M.E.T.; Ja...nsen E.; Grune T.; Gonos E.S.; Franceschi C.; Capri M.; Gradinaru D.; Grubeck-Loebenstein B.; Sikora E.; Stuetz W.; Weber D.; Toussaint O.; Debacq-Chainiaux F.; Hervonen A.; Hurme M.; Slagboom P.E.; Schon C.; Bernhardt J.; Breusing N.; Duncan T.; Passarino G.; Bellizzi D.; Provinciali M. | 2023-01-01 | THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | - | 1.01 Articolo in rivista | Giacconietal_2023.pdf; glac154_suppl_supplementary_material.docx |
| Biomarkers of aging in frailty and age-associated disorders: State of the art and future perspective | Salvioli S.; Basile M.S.; Bencivenga L.; Carrino S.; Conte M.; Damanti S.; De Lorenzo R.; Fiorenz...ato E.; Gialluisi A.; Ingannato A.; Antonini A.; Baldini N.; Capri M.; Cenci S.; Iacoviello L.; Nacmias B.; Olivieri F.; Rengo G.; Querini P.R.; Lattanzio F. | 2023-01-01 | AGEING RESEARCH REVIEWS | - | 1.01 Articolo in rivista | Salvioli et al ARR biomarker 2023.pdf |
| Circulating miR-122-5p, miR-92a-3p, and miR-18a-5p as Potential Biomarkers in Human Liver Transplantation Follow-Up | Morsiani C.; Collura S.; Sevini F.; Ciurca E.; Bertuzzo V.R.; Franceschi C.; Grazi G.L.; Cescon M....; Capri M. | 2023-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | Morsiani_2023_ijms.pdf; ijms-24-03457-s001.zip |
| Long-term human spaceflight and inflammaging: Does it promote aging? | Miriam Capri, Maria Conte, Erika Ciurca, Chiara Pirazzini, Paolo Garagnani, Aurelia Santoro, Fede...rica Longo, Stefano Salvioli, Patrick Lau, Ralf Moeller, Jens Jordan, Thomas Illig, Maria-Moreno Villanueva, Markus Gruber, Alexander Bürkle, Claudio Franceschi, Jörn Rittweger | 2023-01-01 | AGEING RESEARCH REVIEWS | - | 1.01 Articolo in rivista | 1-s2.0-S1568163723000685-main.pdf |
| The expression pattern of GDF15 in human brain changes during aging and in Alzheimer's disease | Chiariello, Antonio; Valente, Sabrina; Pasquinelli, Gianandrea; Baracca, Alessandra; Sgarbi, Gian...luca; Solaini, Giancarlo; Medici, Valentina; Fantini, Valentina; Poloni, Tino Emanuele; Tognocchi, Monica; Arcaro, Marina; Galimberti, Daniela; Franceschi, Claudio; Capri, Miriam; Salvioli, Stefano; Conte, Maria | 2023-01-01 | FRONTIERS IN AGING NEUROSCIENCE | - | 1.01 Articolo in rivista | Chiariello et al Front Aging Neurosci 2023.pdf; TIf4711.zip |
| Uncovering the Relationship between Selenium Status, Age, Health, and Dietary Habits: Insights from a Large Population Study including Nonagenarian Offspring from the MARK-AGE Project | Giacconi R.; Piacenza F.; Aversano V.; Zampieri M.; Bürkle A.; Villanueva M.M.; Dollé M.E.T.; Jan...sen E.; Grune T.; Gonos E.S.; Franceschi C.; Capri M.; Weinberger B.; Sikora E.; Toussaint O.; Debacq-Chainiaux F.; Stuetz W.; Slagboom P.E.; Bernhardt J.; Fernández-Sánchez M.L.; Provinciali M.; Malavolta M. | 2023-01-01 | NUTRIENTS | - | 1.01 Articolo in rivista | Giacconi_2023nutrients.pdf; nutrients-15-02182-s001.zip |
| A Targeted Epigenetic Clock for the Prediction of Biological Age | Gensous, Noémie; Sala, Claudia; Pirazzini, Chiara; Ravaioli, Francesco; Milazzo, Maddalena; Kwiat...kowska, Katarzyna Malgorzata; Marasco, Elena; De Fanti, Sara; Giuliani, Cristina; Pellegrini, Camilla; Santoro, Aurelia; Capri, Miriam; Salvioli, Stefano; Monti, Daniela; Castellani, Gastone; Franceschi, Claudio; Bacalini, Maria Giulia; Garagnani, Paolo | 2022-01-01 | CELLS | - | 1.01 Articolo in rivista | cells-11-04044.pdf |
| Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease | de Eguileor M.; Grimaldi A.; Pulze L.; Acquati F.; Morsiani C.; Capri M. | 2022-01-01 | MECHANISMS OF AGEING AND DEVELOPMENT | - | 1.01 Articolo in rivista | - |
| Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome | Morsiani C.; Bacalini M.G.; Collura S.; Moreno-Villanueva M.; Breusing N.; Burkle A.; Grune T.; F...ranceschi C.; De Eguileor M.; Capri M. | 2022-01-01 | MECHANISMS OF AGEING AND DEVELOPMENT | - | 1.01 Articolo in rivista | Morsianietal_MAD22.pdf; 1-s2.0-S0047637422000732-mmc1.jpg |
| Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics | Kananen L.; Hurme M.; Burkle A.; Moreno-Villanueva M.; Bernhardt J.; Debacq-Chainiaux F.; Grubeck...-Loebenstein B.; Malavolta M.; Basso A.; Piacenza F.; Collino S.; Gonos E.S.; Sikora E.; Gradinaru D.; Jansen E.H.J.M.; Dolle M.E.T.; Salmon M.; Stuetz W.; Weber D.; Grune T.; Breusing N.; Simm A.; Capri M.; Franceschi C.; Slagboom E.; Talbot D.; Libert C.; Raitanen J.; Koskinen S.; Harkanen T.; Stenholm S.; Ala-Korpela M.; Lehtimaki T.; Raitakari O.T.; Ukkola O.; Kahonen M.; Jylha M.; Jylhava J. | 2022-01-01 | GEROSCIENCE | - | 1.01 Articolo in rivista | Kananen_cfDNA_JGS_22.pdf; 11357_2022_590_MOESM2_ESM.xlsx |
| Current approaches of anti-age related diseases: From molecules up to whole organism | Capri M.; Morsiani C. | 2022-01-01 | MECHANISMS OF AGEING AND DEVELOPMENT | - | 1.01 Articolo in rivista | EDitorialMAD_22.pdf |