CRIS Current Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishGrowing evidence supports the critical role of lipid peroxidation products in the control of cell proliferation.In previous studies we demonstrated the e fficient restriction of the proliferation rate in several cell lines resulting from the in vitro treatment with endogenous lipid polar components of cell membranes.Among these,9-hydroxystearic acid (9-HSA),a primary intermediate of lipid peroxidation,induced a signi ficant arrest in G0/G1 in HT29 colon cancer cells.In response to 9-HSA treatment of HT29 we observed cell growth arrest and increase in p21 WAF1 expression both at the transcriptional and the translational levels.Growth of p21 WAF1 -deleted HCT116 human colon carcinoma cells was not inhibited by 9-HSA.We present evidence that p21 WAF1 is required for 9-HSA mediated growth arrest in human colon carcinoma cells. 2003 Elsevier Inc.All rights reserved.
| Titolo: | 9-Hydroxystearic acid upregulates p21WAF1 in HT29 cancer cells. | |
| Autore/i: | CALONGHI, NATALIA; CAPPADONE, CONCETTINA; PAGNOTTA, ELEONORA; FARRUGGIA, GIOVANNA; BUONTEMPO, FRANCESCA; BOGA, CARLA; G. L. BRUSA; SANTUCCI, MARIA ALESSANDRA; MASOTTI, LANFRANCO | |
| Autore/i Unibo: | ||
| Anno: | 2004 | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.bbrc.2003.12.066 | |
| Abstract: | Growing evidence supports the critical role of lipid peroxidation products in the control of cell proliferation.In previous studies we demonstrated the e fficient restriction of the proliferation rate in several cell lines resulting from the in vitro treatment with endogenous lipid polar components of cell membranes.Among these,9-hydroxystearic acid (9-HSA),a primary intermediate of lipid peroxidation,induced a signi ficant arrest in G0/G1 in HT29 colon cancer cells.In response to 9-HSA treatment of HT29 we observed cell growth arrest and increase in p21 WAF1 expression both at the transcriptional and the translational levels.Growth of p21 WAF1 -deleted HCT116 human colon carcinoma cells was not inhibited by 9-HSA.We present evidence that p21 WAF1 is required for 9-HSA mediated growth arrest in human colon carcinoma cells. 2003 Elsevier Inc.All rights reserved. | |
| Data prodotto definitivo in UGOV: | 2005-10-03 16:24:06 | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11585/2022
Copyright © 2021