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EnglishGrowing evidence supports the critical role of lipid peroxidation products in the control of cell proliferation.In previous studies we demonstrated the e fficient restriction of the proliferation rate in several cell lines resulting from the in vitro treatment with endogenous lipid polar components of cell membranes.Among these,9-hydroxystearic acid (9-HSA),a primary intermediate of lipid peroxidation,induced a signi ficant arrest in G0/G1 in HT29 colon cancer cells.In response to 9-HSA treatment of HT29 we observed cell growth arrest and increase in p21 WAF1 expression both at the transcriptional and the translational levels.Growth of p21 WAF1 -deleted HCT116 human colon carcinoma cells was not inhibited by 9-HSA.We present evidence that p21 WAF1 is required for 9-HSA mediated growth arrest in human colon carcinoma cells. 2003 Elsevier Inc.All rights reserved.
| Titolo: | 9-Hydroxystearic acid upregulates p21WAF1 in HT29 cancer cells. |
| Autore/i: | CALONGHI, NATALIA; CAPPADONE, CONCETTINA; PAGNOTTA, ELEONORA; FARRUGGIA, GIOVANNA; BUONTEMPO, FRANCESCA; BOGA, CARLA; G. L. BRUSA; SANTUCCI, MARIA ALESSANDRA; MASOTTI, LANFRANCO |
| Autore/i Unibo: | |
| Anno: | 2004 |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.bbrc.2003.12.066 |
| Abstract: | Growing evidence supports the critical role of lipid peroxidation products in the control of cell proliferation.In previous studies we demonstrated the e fficient restriction of the proliferation rate in several cell lines resulting from the in vitro treatment with endogenous lipid polar components of cell membranes.Among these,9-hydroxystearic acid (9-HSA),a primary intermediate of lipid peroxidation,induced a signi ficant arrest in G0/G1 in HT29 colon cancer cells.In response to 9-HSA treatment of HT29 we observed cell growth arrest and increase in p21 WAF1 expression both at the transcriptional and the translational levels.Growth of p21 WAF1 -deleted HCT116 human colon carcinoma cells was not inhibited by 9-HSA.We present evidence that p21 WAF1 is required for 9-HSA mediated growth arrest in human colon carcinoma cells. 2003 Elsevier Inc.All rights reserved. |
| Data prodotto definitivo in UGOV: | 2005-10-03 16:24:06 |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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