The paper describes the design of a smart sensor for label-free detection of DNA hybridization. The sensor is based on a direct electrical transduction principle: it measures impedance variation at the interface between a bio-functionalized electrode and a solution containing the analyte. The smart sensor includes a complete signal conditioning and processing subsystem based on an embedded μ-controller. We outline the sensor architecture, and we describe in detail board-level integration as well as hardware and software implementation and design choices. The accuracy of our embedded solution has been evaluated by comparing it with a high-cost laboratory setup. Moreover, we provide measurements of real sensing structures which demonstrate the functionality of our system in the field

Hardware-Software Design of a Smart Sensor for Fully-Electronic DNA Hybridization Detection

STAGNI DEGLI ESPOSTI, CLAUDIO;GUIDUCCI, CARLOTTA;LANZONI, MASSIMO;BENINI, LUCA;RICCO', BRUNO
2005

Abstract

The paper describes the design of a smart sensor for label-free detection of DNA hybridization. The sensor is based on a direct electrical transduction principle: it measures impedance variation at the interface between a bio-functionalized electrode and a solution containing the analyte. The smart sensor includes a complete signal conditioning and processing subsystem based on an embedded μ-controller. We outline the sensor architecture, and we describe in detail board-level integration as well as hardware and software implementation and design choices. The accuracy of our embedded solution has been evaluated by comparing it with a high-cost laboratory setup. Moreover, we provide measurements of real sensing structures which demonstrate the functionality of our system in the field
Design, Automation and Test in Europe Conference and Exhibition 2005. Proceedings
198
203
C. Stagni;C. Guiducci;M. Lanzoni;L. Benini;B. Ricco'
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/16915
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