The selection criteria in liver transplantation for HCC are a matter of debate. We reviewed our series, comparing two periods: before and after 1996, when we started to apply the Milan criteria. The study population was composed of patients with a preoperative diagnosis of HCC, confirmed by the pathological report and with a survival of >1 year. Preoperative staging as revealed by radiological imagining was distinguished from postoperative data, including the variable of tumor volume. After 1996 tumor recurrences significantly decreased (6 out of 15 cases, 40% vs. 3 out of 48, 6.3%, P < .005) and 5-year patient survival improved (42% vs. 83%, P < .005). Not meeting the Milan criteria was significantly related to higher recurrence rate (37.5% vs. 12.7%, P < .05) and to lower 5-year patient survival (38% vs. 78%, P < .005%) in the preoperative analysis, but not in the postoperative one. The alfa-fetoprotein level of more than 30 ng/dL and the preoperative tumor volume of more than 28 cm3 predicted HCC recurrences in the univariate and mutivariate analysis (P < .005 and P < .05, respectively). The ROC curve showed a linear correlation between preoperative tumor volume and HCC recurrence. Milan criteria significantly reduced tumor recurrences after liver transplantation, improving long-term survival. In conclusion, the efficacy of tumor selection criteria must be analyzed with the use of preoperative data, to avoid bias of the postoperative evaluation. Tumor volume and alfa-fetoprotein level may improve the selection of patients.

RAVAIOLI M, ERCOLANI G, CESCON M, VETRONE G, VOCI C, GRIGIONI WF, et al. (2004). Liver transplantation for hepatocellular carcinoma: further considerations on selection criteria. LIVER TRANSPLANTATION, 10, 1195-1202 [10.1002/lt.20239].

Liver transplantation for hepatocellular carcinoma: further considerations on selection criteria.

RAVAIOLI, MATTEO;ERCOLANI, GIORGIO;CESCON, MATTEO;VETRONE, GAETANO;GRIGIONI, FRANCO;D'ERRICO, ANTONIETTA;CAVALLARI, ANTONINO;GRAZI, GIAN LUCA
2004

Abstract

The selection criteria in liver transplantation for HCC are a matter of debate. We reviewed our series, comparing two periods: before and after 1996, when we started to apply the Milan criteria. The study population was composed of patients with a preoperative diagnosis of HCC, confirmed by the pathological report and with a survival of >1 year. Preoperative staging as revealed by radiological imagining was distinguished from postoperative data, including the variable of tumor volume. After 1996 tumor recurrences significantly decreased (6 out of 15 cases, 40% vs. 3 out of 48, 6.3%, P < .005) and 5-year patient survival improved (42% vs. 83%, P < .005). Not meeting the Milan criteria was significantly related to higher recurrence rate (37.5% vs. 12.7%, P < .05) and to lower 5-year patient survival (38% vs. 78%, P < .005%) in the preoperative analysis, but not in the postoperative one. The alfa-fetoprotein level of more than 30 ng/dL and the preoperative tumor volume of more than 28 cm3 predicted HCC recurrences in the univariate and mutivariate analysis (P < .005 and P < .05, respectively). The ROC curve showed a linear correlation between preoperative tumor volume and HCC recurrence. Milan criteria significantly reduced tumor recurrences after liver transplantation, improving long-term survival. In conclusion, the efficacy of tumor selection criteria must be analyzed with the use of preoperative data, to avoid bias of the postoperative evaluation. Tumor volume and alfa-fetoprotein level may improve the selection of patients.
2004
RAVAIOLI M, ERCOLANI G, CESCON M, VETRONE G, VOCI C, GRIGIONI WF, et al. (2004). Liver transplantation for hepatocellular carcinoma: further considerations on selection criteria. LIVER TRANSPLANTATION, 10, 1195-1202 [10.1002/lt.20239].
RAVAIOLI M; ERCOLANI G; CESCON M; VETRONE G; VOCI C; GRIGIONI WF; D'ERRICO A; BALLARDINI G; CAVALLARI A; GRAZI G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/1649
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