The preparation of two new series of chiral 1,2-diamines and their use in the [ZnR2-diamine]-catalyzed asymmetric hydrosilylation of acetophenone with poly(methylhydrosiloxane) (PMHS) in an aprotic medium is reported. The effect of structural modifications of the secondary diamine ligand, in particular a possible cooperative effect of two different types of chiral centers, on the N-benzylic side-arms and on the ethylene bridge of the diamine skeleton, has been investigated. A new diamine ligand giving up to 91% ee is described.
V. Bette, A. Mortreux, F. Ferioli, G. Martelli, D. Savoia, J.-F. Carpentier (2004). New chiral 1,2-diamines and their use in zinc.catalyzed asymmetric hydrosilylation of acetophenone. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2005, 3040-3045.
New chiral 1,2-diamines and their use in zinc.catalyzed asymmetric hydrosilylation of acetophenone
FERIOLI, FEDERICO;MARTELLI, GIANLUCA;SAVOIA, DIEGO;
2004
Abstract
The preparation of two new series of chiral 1,2-diamines and their use in the [ZnR2-diamine]-catalyzed asymmetric hydrosilylation of acetophenone with poly(methylhydrosiloxane) (PMHS) in an aprotic medium is reported. The effect of structural modifications of the secondary diamine ligand, in particular a possible cooperative effect of two different types of chiral centers, on the N-benzylic side-arms and on the ethylene bridge of the diamine skeleton, has been investigated. A new diamine ligand giving up to 91% ee is described.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
