A series of N-methylthio-beta-lactams with antibacterial activity were thoroughly evaluated as antioxidants. We found that only the presence of a polyphenolic moiety anchored to the beta-lactam ring ensured an adequate antioxidant potency. New compounds, efficiently combining in one structure antioxidant and antibacterial activity, may provide a promising basis for the development of new leads useful in adverse clinical conditions such as in cystic fibrosis patients, in whom colonization by MRSA and epithelial damage by chronic pulmonary oxidative stress take place.
R. Cervellati, P. Galletti, E. Greco, C.E. Cocuzza, R. Musumeci, L. Bardini, et al. (2013). Monocyclic beta-lactams as antibacterial agents: Facing antioxidant activity of N-methylthio-azetidinones. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 60, 340-349 [10.1016/j.ejmech.2012.12.024].
Monocyclic beta-lactams as antibacterial agents: Facing antioxidant activity of N-methylthio-azetidinones
CERVELLATI, RINALDO;GALLETTI, PAOLA;PAOLUCCI, FRANCESCO;PORI, MATTEO;SOLDATI, ROBERTO;GIACOMINI, DARIA
2013
Abstract
A series of N-methylthio-beta-lactams with antibacterial activity were thoroughly evaluated as antioxidants. We found that only the presence of a polyphenolic moiety anchored to the beta-lactam ring ensured an adequate antioxidant potency. New compounds, efficiently combining in one structure antioxidant and antibacterial activity, may provide a promising basis for the development of new leads useful in adverse clinical conditions such as in cystic fibrosis patients, in whom colonization by MRSA and epithelial damage by chronic pulmonary oxidative stress take place.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
