Effective prevention of human cancer with vaccines against viruses, such as HBV and HPV, raises the question whether also non-virus related tumors could be prevented with immunological means. Studies in HER-2-transgenic mice showed that powerful anti-HER-2 vaccines, could almost completely prevent the onset of mammary carcinoma. Protective immune responses were orchestrated by T cells and their cytokines, and effected by antibodies against HER-2 gene product p185. Analogous findings were reported in a variety of other cancer immunoprevention systems, thus leading to the definition of oncoantigens, optimal target antigens that are causally involved in carcinogenesis and cancer progression. Prophylactic HER-2 vaccines were also effective in preventing metastasis outgrowth, indicating that concepts and approaches developed for cancer immunoprevention could prove fruitful in cancer immunotherapy as well. The availability of cancer-prone mice carrying a human HER-2 transgene is now fostering the design of novel vaccines against human p185. A further bridge toward human cancer was recently provided by novel immunodeficient models, like Rag2-/-;Il2rg-/- mice, which are permissive for metastatic spread of human HER-2C cancer cells and can be engrafted with a functional human immune system, allowing for the first time the study of vaccines against oncoantigens to elicit human immune responses against human cancer cells in vivo.

Pier-Luigi Lollini, Carla De Giovanni, Patrizia Nanni (2013). Preclinical HER-2 Vaccines: From Rodent to Human HER-2. FRONTIERS IN ONCOLOGY, 3, 1-7 [10.3389/fonc.2013.00151].

Preclinical HER-2 Vaccines: From Rodent to Human HER-2

LOLLINI, PIER LUIGI;DE GIOVANNI, CARLA;NANNI, PATRIZIA
2013

Abstract

Effective prevention of human cancer with vaccines against viruses, such as HBV and HPV, raises the question whether also non-virus related tumors could be prevented with immunological means. Studies in HER-2-transgenic mice showed that powerful anti-HER-2 vaccines, could almost completely prevent the onset of mammary carcinoma. Protective immune responses were orchestrated by T cells and their cytokines, and effected by antibodies against HER-2 gene product p185. Analogous findings were reported in a variety of other cancer immunoprevention systems, thus leading to the definition of oncoantigens, optimal target antigens that are causally involved in carcinogenesis and cancer progression. Prophylactic HER-2 vaccines were also effective in preventing metastasis outgrowth, indicating that concepts and approaches developed for cancer immunoprevention could prove fruitful in cancer immunotherapy as well. The availability of cancer-prone mice carrying a human HER-2 transgene is now fostering the design of novel vaccines against human p185. A further bridge toward human cancer was recently provided by novel immunodeficient models, like Rag2-/-;Il2rg-/- mice, which are permissive for metastatic spread of human HER-2C cancer cells and can be engrafted with a functional human immune system, allowing for the first time the study of vaccines against oncoantigens to elicit human immune responses against human cancer cells in vivo.
2013
Pier-Luigi Lollini, Carla De Giovanni, Patrizia Nanni (2013). Preclinical HER-2 Vaccines: From Rodent to Human HER-2. FRONTIERS IN ONCOLOGY, 3, 1-7 [10.3389/fonc.2013.00151].
Pier-Luigi Lollini;Carla De Giovanni;Patrizia Nanni
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/148888
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