Aims: The introduction of transcatheter aortic valve implantation (TAVI) has generated a renewed interest in the treatment of high-risk patients with severe aortic stenosis. This study describes the indications and long-term outcome of balloon aortic valvuloplasty (BAY) in recent years. Methods and results: Between 2000 and 2010, 415 consecutive patients at our institution underwent BAY. The number of BAY per year increased sharply after the introduction of TAVI. Patients were 77.5+/-10.9 years old and showed important comorbidities (average logistic EuroSCORE=23.9+/-15.3%). We identified four cohorts according to the indications: 1) bridge for TAVI (B-TAVI; n=162); 2) bridge for aortic valve replacement (B-AVR, n=97); 3) cardiogenic shock (n=23); 4) palliation (n=133). Baseline characteristics were significantly different among groups. In-hospital mortality was 5.1%, and occurred predominantly in patients who underwent BAY in the setting of cardiogenic shock (56.5% vs. around 2% in the other subgroups). Other major events were stroke (0.5%), major vascular complications (2.2%), and life-threatening bleedings (1.5%). The cumulative one-year and two-year mortality rates were 33.2% and 57.4%, respectively, with the highest incidence in the shock group (70.7% and 80.4%) and the lowest in the B-AVR group (21.7% and 38.4%). Rehospitalisation for heart failure was 26.3% at one-year and 47.2% at two-year follow-up. Conclusions: The number of BAV is increasing, mainly due to increased referral of high-risk patients and to the emerging indication of bridge for TAVI. In this complex population, BAV is relatively safe but two-year survival remains poor, and more effective and definitive treatments should be pursued in a timely fashion.

Emerging indications, in-hospital and long-term outcome of balloon aortic valvuloplasty in the transcatheter aortic valve implantation era.

SAIA, FRANCESCO;CIUCA, CRISTINA;TAGLIERI, NEVIO;Palmerini T;BORDONI, BARBARA;MORETTI, CAROLINA;DALL'ARA, GIANNI;BRANZI, ANGELO;MARZOCCHI, ANTONIO
2013

Abstract

Aims: The introduction of transcatheter aortic valve implantation (TAVI) has generated a renewed interest in the treatment of high-risk patients with severe aortic stenosis. This study describes the indications and long-term outcome of balloon aortic valvuloplasty (BAY) in recent years. Methods and results: Between 2000 and 2010, 415 consecutive patients at our institution underwent BAY. The number of BAY per year increased sharply after the introduction of TAVI. Patients were 77.5+/-10.9 years old and showed important comorbidities (average logistic EuroSCORE=23.9+/-15.3%). We identified four cohorts according to the indications: 1) bridge for TAVI (B-TAVI; n=162); 2) bridge for aortic valve replacement (B-AVR, n=97); 3) cardiogenic shock (n=23); 4) palliation (n=133). Baseline characteristics were significantly different among groups. In-hospital mortality was 5.1%, and occurred predominantly in patients who underwent BAY in the setting of cardiogenic shock (56.5% vs. around 2% in the other subgroups). Other major events were stroke (0.5%), major vascular complications (2.2%), and life-threatening bleedings (1.5%). The cumulative one-year and two-year mortality rates were 33.2% and 57.4%, respectively, with the highest incidence in the shock group (70.7% and 80.4%) and the lowest in the B-AVR group (21.7% and 38.4%). Rehospitalisation for heart failure was 26.3% at one-year and 47.2% at two-year follow-up. Conclusions: The number of BAV is increasing, mainly due to increased referral of high-risk patients and to the emerging indication of bridge for TAVI. In this complex population, BAV is relatively safe but two-year survival remains poor, and more effective and definitive treatments should be pursued in a timely fashion.
Saia F;Marrozzini C;Ciuca C;Guastaroba P;Taglieri N;Palmerini T;Bordoni B;Carolina Moretti;Dall'ara G;Branzi A;Marzocchi A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/143864
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