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EnglishInflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm-aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.
| Titolo: | Immune system, cell senescence, aging and longevity - Inflamm-aging reappraised. | |
| Autore/i: | SALVIOLI, STEFANO; LANZARINI, CATIA; CONTE, MARIA; PIRAZZINI, CHIARA; BACALINI, MARIA GIULIA; GARAGNANI, PAOLO; GIULIANI, CRISTINA; FONTANESI, ELISA; OSTAN, RITA; BUCCI, LAURA; SEVINI, FEDERICA; LUKAS YANI, STELLA; BARBIERI, ANNALAURA; LOMARTIRE, LAURA; BORELLI, VINCENZO; VIANELLO, DARIO; BELLAVISTA, ELENA; MARTUCCI, MORENA; CEVENINI, ELISA; PINI, ELISA; SCURTI, MARIA; BIONDI, FIAMMETTA; SANTORO, AURELIA; CAPRI, MIRIAM; FRANCESCHI, CLAUDIO; Monti, D | |
| Autore/i Unibo: | ||
| Anno: | 2013 | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.2174/1381612811319090015 | |
| Abstract: | Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm-aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act. | |
| Data prodotto definitivo in UGOV: | 2013-05-20 | |
| Data stato definitivo: | 2018-02-26T13:35:21Z | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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