The discovery of biomarkers able to predict biological age of individuals is a crucial goal in aging research. Recently, researchers' attention has turn toward epigenetic markers of aging. Using the Illumina Infinium HumanMethylation450 BeadChip on whole blood DNA from a small cohort of 64 subjects of different ages, we identified 3 regions, the CpG islands of ELOVL2, FHL2, and PENK genes, whose methylation level strongly correlates with age. These results were confirmed by the Sequenom's EpiTYPER assay on a larger cohort of 501 subjects from 9 to 99 years, including 7 cord blood samples. Among the 3 genes, ELOVL2 shows a progressive increase in methylation that begins since the very first stage of life (Spearman's correlation coefficient = 0.92) and appears to be a very promising biomarker of aging
Garagnani P., Bacalini M.G., Pirazzini C., Gori D., Giuliani C., Mari D., et al. (2012). Methylation of ELOVL2 gene as a new epigenetic marker of age. AGING CELL, 11(6), 1132-1134 [10.1111/acel.12005].
Methylation of ELOVL2 gene as a new epigenetic marker of age
GARAGNANI, PAOLO;BACALINI, MARIA GIULIA;PIRAZZINI, CHIARA;GORI, DAVIDE;GIULIANI, CRISTINA;Mari D.;CASTELLANI, GASTONE;CAPRI, MIRIAM;SALVIOLI, STEFANO;FRANCESCHI, CLAUDIO
2012
Abstract
The discovery of biomarkers able to predict biological age of individuals is a crucial goal in aging research. Recently, researchers' attention has turn toward epigenetic markers of aging. Using the Illumina Infinium HumanMethylation450 BeadChip on whole blood DNA from a small cohort of 64 subjects of different ages, we identified 3 regions, the CpG islands of ELOVL2, FHL2, and PENK genes, whose methylation level strongly correlates with age. These results were confirmed by the Sequenom's EpiTYPER assay on a larger cohort of 501 subjects from 9 to 99 years, including 7 cord blood samples. Among the 3 genes, ELOVL2 shows a progressive increase in methylation that begins since the very first stage of life (Spearman's correlation coefficient = 0.92) and appears to be a very promising biomarker of aging| File | Dimensione | Formato | |
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