In recent years, organocatalysis has enhanced its importance as a tool for the synthesis of enantiomerically enriched compounds. Among the candidates for organocatalysis, the construction of asymmetric quaternary carbons is regarded as a challenging problem in organic synthesis. In particular, 3,30-disubstituted oxindoles have one or more asymmetric quaternary carbon atoms and they represent a large family of bioactive compounds and synthetic derivatives that mimicry natural products. Therefore they are good targets for drug candidates and in the last two years many papers have appeared on organocatalytic methods for the synthesis of 3,30-disubstituted oxindoles. Moreover, in the last few years 2-substituted and 2,20-disubtituted 3-indolinones have also attracted the interest of chemists. This review aims to cover the literature on these topics from its origin to the end of 2011.

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones / Renato Dalpozzo; Giuseppe Bartoli; Giorgio Bencivenni. - In: CHEMICAL SOCIETY REVIEWS. - ISSN 0306-0012. - STAMPA. - 41:(2012), pp. 7247-7290. [10.1039/c2cs35100e]

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

BARTOLI, GIUSEPPE;BENCIVENNI, GIORGIO
2012

Abstract

In recent years, organocatalysis has enhanced its importance as a tool for the synthesis of enantiomerically enriched compounds. Among the candidates for organocatalysis, the construction of asymmetric quaternary carbons is regarded as a challenging problem in organic synthesis. In particular, 3,30-disubstituted oxindoles have one or more asymmetric quaternary carbon atoms and they represent a large family of bioactive compounds and synthetic derivatives that mimicry natural products. Therefore they are good targets for drug candidates and in the last two years many papers have appeared on organocatalytic methods for the synthesis of 3,30-disubstituted oxindoles. Moreover, in the last few years 2-substituted and 2,20-disubtituted 3-indolinones have also attracted the interest of chemists. This review aims to cover the literature on these topics from its origin to the end of 2011.
2012
Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones / Renato Dalpozzo; Giuseppe Bartoli; Giorgio Bencivenni. - In: CHEMICAL SOCIETY REVIEWS. - ISSN 0306-0012. - STAMPA. - 41:(2012), pp. 7247-7290. [10.1039/c2cs35100e]
Renato Dalpozzo; Giuseppe Bartoli; Giorgio Bencivenni
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/128053
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