The polymorphism of racemic imidazol-1ylsuccinic acid derivatives, a series of compounds previously used as extracellular pH probes for NMR spectroscopy, is investigated by crystallization in different solvents. The mono-ester, (±)-3-(ethoxycarbonyl)-2-(imidazol-1-yl) propionic acid, shows two different polymorphs when recrystallized in absolute ethanol (Form I) or water (Form II), respectively. These two forms have been characterized by optical microscopy, powder X-ray diffraction analysis, and thermogravimetry. Polymorphs I and II can also be distinguished by solid state CP-MAS 13C NMR spectroscopy.

C. Ubide-Barreda, L. Rojas, PJ. Martínez de Paz, V. Righi, P. Ballesteros (2011). Polymorphism of racemic imidazol-1-ylsuccinic acid derivatives. Suitable probes for extracellular pH by magnetic resonance spectroscopic imaging. ARKIVOC, 2011(3), 179-190.

Polymorphism of racemic imidazol-1-ylsuccinic acid derivatives. Suitable probes for extracellular pH by magnetic resonance spectroscopic imaging

RIGHI, VALERIA;
2011

Abstract

The polymorphism of racemic imidazol-1ylsuccinic acid derivatives, a series of compounds previously used as extracellular pH probes for NMR spectroscopy, is investigated by crystallization in different solvents. The mono-ester, (±)-3-(ethoxycarbonyl)-2-(imidazol-1-yl) propionic acid, shows two different polymorphs when recrystallized in absolute ethanol (Form I) or water (Form II), respectively. These two forms have been characterized by optical microscopy, powder X-ray diffraction analysis, and thermogravimetry. Polymorphs I and II can also be distinguished by solid state CP-MAS 13C NMR spectroscopy.
2011
C. Ubide-Barreda, L. Rojas, PJ. Martínez de Paz, V. Righi, P. Ballesteros (2011). Polymorphism of racemic imidazol-1-ylsuccinic acid derivatives. Suitable probes for extracellular pH by magnetic resonance spectroscopic imaging. ARKIVOC, 2011(3), 179-190.
C. Ubide-Barreda; L. Rojas; PJ. Martínez de Paz; V. Righi; P. Ballesteros
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/123816
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