Fatness in pigs is a complex trait for which a large number of genes are expected to be involved. Genetics of human obesity could take advantages from genetic information coming from the pig and vice versa. To these aims, a comprehensive candidate gene approach could be helpful. We catalogued all genes affecting fatness on both species, and identified in silico and by resequencing porcine SNPs on a large number of candidate genes. In addition, we applied a selective genotyping approach to identify markers associated with fat deposition in pigs. This approach was tested genotyping the IGF2 intron3-g.3072G>A mutation and novel markers in the PCSK1 and TBC1D1 genes. Polymorphisms in these genes resulted associated with back fat thickness in Italian Large White pigs

The FAGenomicH project: Towards a whole candidate gene approach to identify markers associated with fatness and production traits in pigs and investigate the pig as a model for human obesity

FONTANESI, LUCA;FRONZA, RAFFAELE;SCOTTI, EMILIO;COLOMBO, MICHELA;SPERONI, CAMILLA;TOGNAZZI, LUCIA;GALIMBERTI, GIULIANO;CALO', DANIELA GIOVANNA;BONORA, ELENA;VARGIOLU, MANUELA;ROMEO, GIOVANNI;CASADIO, RITA;RUSSO, VINCENZO
2009

Abstract

Fatness in pigs is a complex trait for which a large number of genes are expected to be involved. Genetics of human obesity could take advantages from genetic information coming from the pig and vice versa. To these aims, a comprehensive candidate gene approach could be helpful. We catalogued all genes affecting fatness on both species, and identified in silico and by resequencing porcine SNPs on a large number of candidate genes. In addition, we applied a selective genotyping approach to identify markers associated with fat deposition in pigs. This approach was tested genotyping the IGF2 intron3-g.3072G>A mutation and novel markers in the PCSK1 and TBC1D1 genes. Polymorphisms in these genes resulted associated with back fat thickness in Italian Large White pigs
ITALIAN JOURNAL OF ANIMAL SCIENCE
Fontanesi L.; Fronza R.; Scotti E.; Colombo M.; Speroni C.; Tognazzi L.; Galimberti G.; Calò DG; Bonora E.; Vargiolu M.; Romeo G.; Casadio R.; Russo V.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/123776
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