Ethnopharmacological relevance: Rosa canina L. is a medicinal plant largely used in traditional folk medicine. Several compounds from rose hip extracts were reported to display in vitro anti-inflammatory activities. Aim of the study: The in vivo effects of Rosa canina extracts are still poorly investigated. In the present study the anti-inflammatory and the gastroprotective effects of a hydroalcoholic crude extract of Rosa canina fruits were tested in rat. Materials and methods: The anti-inflammatory activity of the extract was tested on the carrageenininduced rat paw edema assay. The gastroprotective effect was investigated on the ethanol-induced gastric damage model. The in vitro antioxidant activity of this extract was also quantified using the Briggs–Rauscher oscillating reaction, the Trolox Equivalent Antioxidant Capacity method, and the Total Phenolic Content. Results: Data show that the Rosa canina extract inhibits the development of carrageenin-induced edema; the anti-inflammatory%2
F. Lattanzio, E. Greco, D. Carretta, R. Cervellati, P. Govoni, E. Speroni (2011). In vivo anti-inflammatory effect of Rosa canina L. extract. JOURNAL OF ETHNOPHARMACOLOGY, 137(1), 880-885 [10.1016/j.jep.2011.07.006].
In vivo anti-inflammatory effect of Rosa canina L. extract
LATTANZIO, FRANCESCA;GRECO, EMANUELA;CARRETTA, DONATELLA;CERVELLATI, RINALDO;SPERONI, ESTER
2011
Abstract
Ethnopharmacological relevance: Rosa canina L. is a medicinal plant largely used in traditional folk medicine. Several compounds from rose hip extracts were reported to display in vitro anti-inflammatory activities. Aim of the study: The in vivo effects of Rosa canina extracts are still poorly investigated. In the present study the anti-inflammatory and the gastroprotective effects of a hydroalcoholic crude extract of Rosa canina fruits were tested in rat. Materials and methods: The anti-inflammatory activity of the extract was tested on the carrageenininduced rat paw edema assay. The gastroprotective effect was investigated on the ethanol-induced gastric damage model. The in vitro antioxidant activity of this extract was also quantified using the Briggs–Rauscher oscillating reaction, the Trolox Equivalent Antioxidant Capacity method, and the Total Phenolic Content. Results: Data show that the Rosa canina extract inhibits the development of carrageenin-induced edema; the anti-inflammatory%2I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
