Revisiting nuclear phospholipase C signalling in MDS

Since the late 1980s, a growing body of evidence has documented that phosphoinositides and their metabolizing enzymes, which regulate a large variety of cellular functions both in the cytoplasm and at the plasma membrane, are present also within the nucleus, where they are involved in processes such as cell proliferation, differentiation, and survival. Recent studies show that nuclear Phospholipase Cb1 (a key phosphoinositide metabolizing enzyme) could be somehow involved in myelodysplastic syndromes (MDS), i.e. hematopoietic disorders that can evolve into acutemyeloid leukemia (AML). This review aims to highlight the most significant and updated findings about Phospholipase C metabolism in the nucleus under pathological conditions, namely MDS and AML.