Our main objective was to compile a data set of highquality proteinfragment complexes and make it publicly available. Once assembled, the data set was challenged using docking procedures to address the following questions: (i) Can molecular docking correctly reproduce the experimentally solved structures? (ii) How thorough must the sampling be to replicate the experimental data? (iii) Can commonly used scoring functions discriminate between the native pose and other energy minima? The data set, named SERAPhiC (Selected Fragment Protein Complexes), is publicly available in a ready-to-dock format (http://www.iit.it/en/drug-discovery-anddevelopment/ seraphic.html). It offers computational medicinal chemists a reliable test set for both in silico protocol assessment and software development.

SERAPhiC: A Benchmark for in Silico Fragment-Based Drug Design

CAVALLI, ANDREA
2011

Abstract

Our main objective was to compile a data set of highquality proteinfragment complexes and make it publicly available. Once assembled, the data set was challenged using docking procedures to address the following questions: (i) Can molecular docking correctly reproduce the experimentally solved structures? (ii) How thorough must the sampling be to replicate the experimental data? (iii) Can commonly used scoring functions discriminate between the native pose and other energy minima? The data set, named SERAPhiC (Selected Fragment Protein Complexes), is publicly available in a ready-to-dock format (http://www.iit.it/en/drug-discovery-anddevelopment/ seraphic.html). It offers computational medicinal chemists a reliable test set for both in silico protocol assessment and software development.
Favia A.D.; Bottegoni G.; Nobeli I.; Bisignano P.; Cavalli A.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/107935
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