Cardiovascular disease is a dominant cause of global death, and atherosclerosis is its pre-eminent precursor, which begins with the loss of endothelium integrity, increased permeability to atherogenic lipoproteins and other pathological phenomena which result in intima-media thickness increase. We describe the case of a 48-year-old woman affected by heterozygous familial hypercholesterolemia and recurrent vulvovaginal candidiasis episodes, periodically treated with oral fluconazole; while she did not use to take any drug for lower total-cholesterol and LDL-cholesterol. After 20 months of therapy with Pravastatin 40 mg daily, we noted an evident regression of diffused intima-media thickness in all vascular districts probed by ultrasound technique. We claim the importance and efficacy of Pravastatin therapy at the full dosage to normalise the lipidemic profile and to slow down the atherosclerosis progression, as has just been demonstrated by a simple and safe diagnostic image technique.

Diffused intima-media thickness regression after 20 months of pravastatin 40 mg treatment: a case report.

CICERO, ARRIGO FRANCESCO GIUSEPPE;GADDI, ANTONIO VITTORINO
2010

Abstract

Cardiovascular disease is a dominant cause of global death, and atherosclerosis is its pre-eminent precursor, which begins with the loss of endothelium integrity, increased permeability to atherogenic lipoproteins and other pathological phenomena which result in intima-media thickness increase. We describe the case of a 48-year-old woman affected by heterozygous familial hypercholesterolemia and recurrent vulvovaginal candidiasis episodes, periodically treated with oral fluconazole; while she did not use to take any drug for lower total-cholesterol and LDL-cholesterol. After 20 months of therapy with Pravastatin 40 mg daily, we noted an evident regression of diffused intima-media thickness in all vascular districts probed by ultrasound technique. We claim the importance and efficacy of Pravastatin therapy at the full dosage to normalise the lipidemic profile and to slow down the atherosclerosis progression, as has just been demonstrated by a simple and safe diagnostic image technique.
Bove M.; Carnevali L.; Cicero A.; Gaddi A.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/106095
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