The nosologic status of fibrous dysplasia (FD), a well-known and relatively common bone lesion, is controversial. Information collected by the CHromosomes And MorPhology (CHAMP) study group on published and unpublished cases of fibrous dysplasia shows the presence of clonal chromosome changes in at least a proportion of these lesions. The chromosome aberrations found in FD lesions have been quite variable and have included both structural and numerical changes. Two of the three cases investigated at the study group had trisomy 2 as the sole acquired anomaly. Combined with previously published data, +2 and rearrangements involving chromosome band 12p13 have each been detected in 3 of 8 cases with abnormal karyotype of 11 in which chromosomal analysis has been performed, suggesting that FD is a neoplastic lesion rather than a 'dysplastic' process, as has been generally believed and as implied by its very name. Copyright (C) 2000 Elsevier Science Inc.
Dal Cin, P., Sciot, R., Brys, P., De Wever, I., Dorfman, H., Fletcher, C.D.M., et al. (2000). Recurrent chromosome aberrations in fibrous dysplasia of the bonea report of the CHAMP study group. CANCER GENETICS AND CYTOGENETICS, 122(1), 30-32 [10.1016/S0165-4608(00)00270-3].
Recurrent chromosome aberrations in fibrous dysplasia of the bonea report of the CHAMP study group
Tallini G.;
2000
Abstract
The nosologic status of fibrous dysplasia (FD), a well-known and relatively common bone lesion, is controversial. Information collected by the CHromosomes And MorPhology (CHAMP) study group on published and unpublished cases of fibrous dysplasia shows the presence of clonal chromosome changes in at least a proportion of these lesions. The chromosome aberrations found in FD lesions have been quite variable and have included both structural and numerical changes. Two of the three cases investigated at the study group had trisomy 2 as the sole acquired anomaly. Combined with previously published data, +2 and rearrangements involving chromosome band 12p13 have each been detected in 3 of 8 cases with abnormal karyotype of 11 in which chromosomal analysis has been performed, suggesting that FD is a neoplastic lesion rather than a 'dysplastic' process, as has been generally believed and as implied by its very name. Copyright (C) 2000 Elsevier Science Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
