The role of mitochondrial dysfunction underlying increased susceptibility to cerebrovascular disease in hypertension, previously detected in stroke-prone spontaneously hypertensive rats (SHR-SP) fed with a high-salt stroke-permissive Japanese-style diet (JD), was studied for the first time at the molecular level. The Complex I (CI) (dis)assembly in the supramolecular organization of respiratory supercomplexes (SCs) has emerged as the main component impairing the kinetic activity and SCs organization of mitochondrial respiration in SHR-SP compared with the SHR-stroke resistant (SR) strain upon the same dietary condition. The leak of substrate channeling and SCs arrangement in CI-dependent NADH oxidation in JD-fed SHR-SP was not detected in SHR-SR upon the same dietary regimen. Our results highlight that SCs association linked to CI dynamic and stability protects from stroke manifestation.
Cugliari, A., Algieri, C., Glogowski, P.A., Granata, S., Cotugno, M., Bernardini, C., et al. (2025). The Function and Supramolecular Assembly of the Mitochondrial Respiratory Complexes Underlie Hypertension-Related Stroke Susceptibility in a Model of Complex Human Disease. BIOFACTORS, 51(6), 1-8 [10.1002/biof.70055].
The Function and Supramolecular Assembly of the Mitochondrial Respiratory Complexes Underlie Hypertension-Related Stroke Susceptibility in a Model of Complex Human Disease
Cugliari A.Primo
;Algieri C.;Glogowski P. A.;Granata S.;Cotugno M.;Bernardini C.;Trombetti F.;Fabbri M.;Nesci S.
Ultimo
2025
Abstract
The role of mitochondrial dysfunction underlying increased susceptibility to cerebrovascular disease in hypertension, previously detected in stroke-prone spontaneously hypertensive rats (SHR-SP) fed with a high-salt stroke-permissive Japanese-style diet (JD), was studied for the first time at the molecular level. The Complex I (CI) (dis)assembly in the supramolecular organization of respiratory supercomplexes (SCs) has emerged as the main component impairing the kinetic activity and SCs organization of mitochondrial respiration in SHR-SP compared with the SHR-stroke resistant (SR) strain upon the same dietary condition. The leak of substrate channeling and SCs arrangement in CI-dependent NADH oxidation in JD-fed SHR-SP was not detected in SHR-SR upon the same dietary regimen. Our results highlight that SCs association linked to CI dynamic and stability protects from stroke manifestation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
