The acute effect of glyphosate on heart mitochondria does not impair the bioenergetics

Considering the important role of mitochondria in mammalian cells and the close correlation between mitochondrial dysfunction and various diseases, this study evaluated the potential toxicity of glyphosate on mitochondrial function in swine heart mitochondria. The results indicated that glyphosate did not have a significant effect on mitochondrial respiration, mitochondrial swelling, and F1FO-ATPase activity under the experimental conditions tested. These findings suggest that, in this model, glyphosate alone may not exert a direct cardiotoxic effect on mitochondrial bioenergetics. Caution is warranted when extrapolating these results to human health, as differences in species, exposure levels, and experimental conditions may influence outcomes. The toxicity observed in glyphosate-based herbicides could involve adjuvants or synergistic interactions between glyphosate and other formulation components, as proposed by other studies.