Oxindoles containing a spiro quaternary stereogenic center as part of a pyrrolidinyl or cyclohexyl ring, are a privileged structural core of natural and synthetic alkaloids, which exhibit important biological and medicinal activity.With the aim of expanding our previous studies on the enantioselective synthesis of spiro compounds with an oxindole as a core feature, we decided to investigate the unprecedented enantioselective nitrocyclopropanation of oxindoles
Fabio Pesciaioli, Paolo Righi, Andrea Mazzanti, Giuseppe Bartoli, Giorgio Bencivenni (2011). Organocatalytic Michael–Alkylation Cascade: The Enantioselective Nitrocyclopropanation of Oxindoles. CHEMISTRY-A EUROPEAN JOURNAL, 17, 2842-2845 [10.1002/chem.201003423].
Organocatalytic Michael–Alkylation Cascade: The Enantioselective Nitrocyclopropanation of Oxindoles
PESCIAIOLI, FABIO;RIGHI, PAOLO;MAZZANTI, ANDREA;BARTOLI, GIUSEPPE;BENCIVENNI, GIORGIO
2011
Abstract
Oxindoles containing a spiro quaternary stereogenic center as part of a pyrrolidinyl or cyclohexyl ring, are a privileged structural core of natural and synthetic alkaloids, which exhibit important biological and medicinal activity.With the aim of expanding our previous studies on the enantioselective synthesis of spiro compounds with an oxindole as a core feature, we decided to investigate the unprecedented enantioselective nitrocyclopropanation of oxindolesI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
