Oxindoles containing a spiro quaternary stereogenic center as part of a pyrrolidinyl or cyclohexyl ring, are a privileged structural core of natural and synthetic alkaloids, which exhibit important biological and medicinal activity.With the aim of expanding our previous studies on the enantioselective synthesis of spiro compounds with an oxindole as a core feature, we decided to investigate the unprecedented enantioselective nitrocyclopropanation of oxindoles

Organocatalytic Michael–Alkylation Cascade: The Enantioselective Nitrocyclopropanation of Oxindoles

PESCIAIOLI, FABIO;RIGHI, PAOLO;MAZZANTI, ANDREA;BARTOLI, GIUSEPPE;BENCIVENNI, GIORGIO
2011

Abstract

Oxindoles containing a spiro quaternary stereogenic center as part of a pyrrolidinyl or cyclohexyl ring, are a privileged structural core of natural and synthetic alkaloids, which exhibit important biological and medicinal activity.With the aim of expanding our previous studies on the enantioselective synthesis of spiro compounds with an oxindole as a core feature, we decided to investigate the unprecedented enantioselective nitrocyclopropanation of oxindoles
Fabio Pesciaioli; Paolo Righi; Andrea Mazzanti; Giuseppe Bartoli; Giorgio Bencivenni
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/103467
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