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EnglishOur results regarding the adverse prognostic significance of high expression of Ang-2 by CLL cells are substantially in keeping with Hu¨ttmann et al. Importantly, in our series, CLL patients expressing at diagnosis high levels of Ang-2 usually had more advanced clinical stage and a higher percentage of CD38þ cells, had unmutated immunoglobulin status and unfavorable cytogenetics and had a shorter progression-free survival. These associations support the idea of the involvement of Ang-2 in the mechanisms of CLL disease progression. In addition, both circulating and BM-infiltrating Ig-unmutated CLL B-cells are able to express higher levels of Ang-2 than Ig-mutated CLL and normal B cells, suggesting the presence of an intrinsic defect in Ang-2 expression that could be pathogenetically relevant in CLL marrow microenvironment and could be involved in the differential clinical behavior of Ig-mutated and Ig-unmutated CLL cases.
| Titolo: | Angiopoietin-2 expression in B-cell chronic lymphocytic leukemia: association with clinical outcome and immunoglobulin heavy-chain mutational status | |
| Autore/i: | Maffei R.; Marasca R.; Martinelli S.; Castelli I.; Santachiara R.; MORANDI, ELENA; Zucchini P.; Fontana M.; Giacobbi F.; SILINGARDI, PAOLA; Bonacorsi G.; Temperani P.; Masini L.; COLACCI, ANNAMARIA; Serra R.; Torelli G. | |
| Autore/i Unibo: | ||
| Anno: | 2007 | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/sj.leu.2404650 | |
| Abstract: | Our results regarding the adverse prognostic significance of high expression of Ang-2 by CLL cells are substantially in keeping with Hu¨ttmann et al. Importantly, in our series, CLL patients expressing at diagnosis high levels of Ang-2 usually had more advanced clinical stage and a higher percentage of CD38þ cells, had unmutated immunoglobulin status and unfavorable cytogenetics and had a shorter progression-free survival. These associations support the idea of the involvement of Ang-2 in the mechanisms of CLL disease progression. In addition, both circulating and BM-infiltrating Ig-unmutated CLL B-cells are able to express higher levels of Ang-2 than Ig-mutated CLL and normal B cells, suggesting the presence of an intrinsic defect in Ang-2 expression that could be pathogenetically relevant in CLL marrow microenvironment and could be involved in the differential clinical behavior of Ig-mutated and Ig-unmutated CLL cases. | |
| Data prodotto definitivo in UGOV: | 2013-05-21 09:57:43 | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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