The in vitro degradation of a commercial biodegradable hydroxyapatite (HA)-polymer(epsilon-caprolactone)-poly(oxyethylene)-poliepsilon-caprolactone) block copolymer PCL-POE-PCL) composite membrane was investigated by Raman spectroscopy, in two enzymatic solutions, at 37°C: esterase and -chymotrypsin in saline phosphate buffer (SPB, pH 7.4). The degradation was found to be faster in the enzymatic media than in SPB and alkaline solutions. The fastest degradation rate was observed in esterase solution. The trend of properly chosen Raman intensity ratios indicated that both polymeric and apatitic components are involved in degradation. The former underwent preferential degradation of POE blocks, HA is removed by the degradation media faster than the polymer. Raman spectroscopy proved a valid tool for investigating the degradation of the membrane.

Raman study on the biodegradation of a composite periodontal membrane

REGGIANI, MATTEO;TADDEI, PAOLA;TINTI, ANNA;FAGNANO, CONCEZIO
2004

Abstract

The in vitro degradation of a commercial biodegradable hydroxyapatite (HA)-polymer(epsilon-caprolactone)-poly(oxyethylene)-poliepsilon-caprolactone) block copolymer PCL-POE-PCL) composite membrane was investigated by Raman spectroscopy, in two enzymatic solutions, at 37°C: esterase and -chymotrypsin in saline phosphate buffer (SPB, pH 7.4). The degradation was found to be faster in the enzymatic media than in SPB and alkaline solutions. The fastest degradation rate was observed in esterase solution. The trend of properly chosen Raman intensity ratios indicated that both polymeric and apatitic components are involved in degradation. The former underwent preferential degradation of POE blocks, HA is removed by the degradation media faster than the polymer. Raman spectroscopy proved a valid tool for investigating the degradation of the membrane.
GNSR 2003
80
85
M. Reggiani; P. Taddei; A. Tinti; C. Fagnano
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/10291
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