Recent evidence suggests that the development of skin lesions from arsenic exposure may be mediated by increases in the expression of various growth factors, including transforming growth factor-alpha (TGFa). To investigate this association in humans, levels of total urinary arsenic and urinary TGFe were determined in 41 individuals with and without arsenic-associated skin lesions from Bangladesh who have chronic exposure to arsenic in their drinking water. After adjusting for age and sex, to tal urinary arsenic was found to be correlated with urinary TGFa (R' = 0.37; p< 0.0001), particularly in those individuals with arsenic-associated skin lesions (R} = 0.70; p<0.0001). Stratification of the cohort into quartiles based on urinary TGFa levels demonstrated a trend of increasing odds ratios for the presence of arsenic-associated skin lesions with increasing urinary TGFa, although this was not significant (p = 0.15). These results suggest that urinary TGFa may be a useful biomarker for the epidermal effects of arsenic exposure.
Do, T., Gambelunghe, A., Ahsan, H., Graziano, J., Perrin, M., Slavkovich, V., et al. (2001). Urinary tranforming growth factor-alpha in individuals exposed to arsenic in drinking water in Bangladesh. BIOMARKERS, 6 (2)((2)), 127-132.
Urinary tranforming growth factor-alpha in individuals exposed to arsenic in drinking water in Bangladesh
GAMBELUNGHE, Angela;
2001
Abstract
Recent evidence suggests that the development of skin lesions from arsenic exposure may be mediated by increases in the expression of various growth factors, including transforming growth factor-alpha (TGFa). To investigate this association in humans, levels of total urinary arsenic and urinary TGFe were determined in 41 individuals with and without arsenic-associated skin lesions from Bangladesh who have chronic exposure to arsenic in their drinking water. After adjusting for age and sex, to tal urinary arsenic was found to be correlated with urinary TGFa (R' = 0.37; p< 0.0001), particularly in those individuals with arsenic-associated skin lesions (R} = 0.70; p<0.0001). Stratification of the cohort into quartiles based on urinary TGFa levels demonstrated a trend of increasing odds ratios for the presence of arsenic-associated skin lesions with increasing urinary TGFa, although this was not significant (p = 0.15). These results suggest that urinary TGFa may be a useful biomarker for the epidermal effects of arsenic exposure.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
