LOI, MANUELA
LOI, MANUELA
DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE
Collaboratori
First in Class Dual Non-ATP-Competitive Glycogen Synthase Kinase 3β/Histone Deacetylase Inhibitors as a Potential Therapeutic to Treat Alzheimer’s Disease
2024 Santini A.; Tassinari E.; Poeta E.; Loi M.; Ciani E.; Trazzi S.; Piccarducci R.; Daniele S.; Martini C.; Pagliarani B.; Tarozzi A.; Bersani M.; Spyrakis F.; Danková D.; Olsen C.A.; Soldati R.; Tumiatti V.; Montanari S.; De Simone A.; Milelli A.
Cardiac Functional and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder
2023 Loi, Manuela; Bastianini, Stefano; Candini, Giulia; Rizzardi, Nicola; Medici, Giorgio; Papa, Valentina; Gennaccaro, Laura; Mottolese, Nicola; Tassinari, Marianna; Uguagliati, Beatrice; Berteotti, Chiara; Martire, Viviana Lo; Zoccoli, Giovanna; Cenacchi, Giovanna; Trazzi, Stefania; Bergamini, Christian; Ciani, Elisabetta
Early-onset brain alterations during postnatal development in a mouse model of CDKL5 deficiency disorder
2023 Tassinari, Marianna; Uguagliati, Beatrice; Trazzi, Stefania; Cerchier, Camilla Bruna; Cavina, Ottavia Vera; Mottolese, Nicola; Loi, Manuela; Candini, Giulia; Medici, Giorgio; Ciani, Elisabetta
Voluntary Running Improves Behavioral and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder
2023 Mottolese, Nicola; Uguagliati, Beatrice; Tassinari, Marianna; Cerchier, Camilla Bruna; Loi, Manuela; Candini, Giulia; Rimondini, Roberto; Medici, Giorgio; Trazzi, Stefania; Ciani, Elisabetta
Expression of a Secretable, Cell-Penetrating CDKL5 Protein Enhances the Efficacy of Gene Therapy for CDKL5 Deficiency Disorder
2022 Medici, Giorgio; Tassinari, Marianna; Galvani, Giuseppe; Bastianini, Stefano; Gennaccaro, Laura; Loi, Manuela; Mottolese, Nicola; Alvente, Sara; Berteotti, Chiara; Sagona, Giulia; Lupori, Leonardo; Candini, Giulia; Baggett, Helen Rappe; Zoccoli, Giovanna; Giustetto, Maurizio; Muotri, Alysson; Pizzorusso, Tommaso; Nakai, Hiroyuki; Trazzi, Stefania; Ciani, Elisabetta
Luteolin Treatment Ameliorates Brain Development and Behavioral Performance in a Mouse Model of CDKL5 Deficiency Disorder
2022 Tassinari, Marianna; Mottolese, Nicola; Galvani, Giuseppe; Ferrara, Domenico; Gennaccaro, Laura; Loi, Manuela; Medici, Giorgio; Candini, Giulia; Rimondini, Roberto; Ciani, Elisabetta; Trazzi, Stefania
A GABAB receptor antagonist rescues functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder
2021 Laura Gennaccaro, Claudia Fuchs, Manuela Loi, Vincenzo Roncacè, Stefania Trazzi, Yassine Ait-Bali, Giuseppe Galvani, Anna Cecilia Berardi, Giorgio Medici, Marianna Tassinari, Elisa Ren, Roberto Rimondini, Maurizio Giustetto, Giorgio Aicardi, Elisabetta Ciani
Age-related cognitive and motor decline in a mouse model of CDKL5 deficiency disorder is associated with increased neuronal senescence and death
2021 Gennaccaro L.; Fuchs C.; Loi M.; Pizzo R.; Alvente S.; Berteotti C.; Lupori L.; Sagona G.; Galvani G.; Gurgone A.; Raspanti A.; Medici G.; Tassinari M.; Trazzi S.; Ren E.; Rimondini R.; Pizzorusso T.; Zoccoli G.; Giustetto M.; Ciani E.
Inhibition of microglia over-activation restores neuronal survival and maturation in a mouse model of CDKL5 deficiency disorder
2021 Nicola Mottolese, Giuseppe Galvani, Laura Gennaccaro, Manuela Loi, Giorgio Medici, Marianna Tassinari, Stefania Trazzi, Elisabetta Ciani
Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder
2021 Galvani, Giuseppe; Mottolese, Nicola; Gennaccaro, Laura; Loi, Manuela; Medici, Giorgio; Tassinari, Marianna; Fuchs, Claudia; Ciani, Elisabetta; Trazzi, Stefania
Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of CDKL5 Deficiency Disorder
2021 Loi, Manuela; Gennaccaro, Laura; Fuchs, Claudia; Trazzi, Stefania; Medici, Giorgio; Galvani, Giuseppe; Mottolese, Nicola; Tassinari, Marianna; Giorgini, Roberto Rimondini; Milelli, Andrea; Ciani, Elisabetta
Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons
2020 Loi M.; Trazzi S.; Fuchs C.; Galvani G.; Medici G.; Gennaccaro L.; Tassinari M.; Ciani E.
Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models
2020 Zaghini A.; Sarli G.; Barboni C.; Sanapo M.; Pellegrino V.; Diana A.; Linta N.; Rambaldi J.; D'Apice M.R.; Murdocca M.; Baleani M.; Baruffaldi F.; Fognani R.; Mecca R.; Festa A.; Papparella S.; Paciello O.; Prisco F.; Capanni C.; Loi M.; Schena E.; Lattanzi G.; Squarzoni S.
Pharmacotherapy with sertraline rescues brain development and behavior in a mouse model of CDKL5 deficiency disorder
2020 Fuchs C.; Gennaccaro L.; Ren E.; Galvani G.; Trazzi S.; Medici G.; Loi M.; Conway E.; Devinsky O.; Rimondini R.; Ciani E.
Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning
2019 Pellegrini C.; Columbaro M.; Schena E.; Prencipe S.; Andrenacci D.; Iozzo P.; Angela Guzzardi M.; Capanni C.; Mattioli E.; Loi M.; Araujo-Vilar D.; Squarzoni S.; Cinti S.; Morselli P.; Giorgetti A.; Zanotti L.; Gambineri A.; Lattanzi G.
CDKL5 deficiency predisposes neurons to cell death through the deregulation of SMAD3 signaling (vol 29, pg 658, 2019)
2019 Fuchs C.; Medici G.; Trazzi S.; Gennaccaro L.; Galvani G.; Berteotti C.; Ren E.; Loi M.; Ciani E.
Functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder are rescued by a TrkB agonist
2019 Ren E.; Roncace V.; Trazzi S.; Fuchs C.; Medici G.; Gennaccaro L.; Loi M.; Galvani G.; Ye K.; Rimondini R.; Aicardi G.; Ciani E.
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| First in Class Dual Non-ATP-Competitive Glycogen Synthase Kinase 3β/Histone Deacetylase Inhibitors as a Potential Therapeutic to Treat Alzheimer’s Disease | Santini A.; Tassinari E.; Poeta E.; Loi M.; Ciani E.; Trazzi S.; Piccarducci R.; Daniele S.; Mart...ini C.; Pagliarani B.; Tarozzi A.; Bersani M.; Spyrakis F.; Danková D.; Olsen C.A.; Soldati R.; Tumiatti V.; Montanari S.; De Simone A.; Milelli A. | 2024-01-01 | ACS CHEMICAL NEUROSCIENCE | - | 1.01 Articolo in rivista | acs-cn.pdf |
| Cardiac Functional and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder | Loi, Manuela; Bastianini, Stefano; Candini, Giulia; Rizzardi, Nicola; Medici, Giorgio; Papa, Vale...ntina; Gennaccaro, Laura; Mottolese, Nicola; Tassinari, Marianna; Uguagliati, Beatrice; Berteotti, Chiara; Martire, Viviana Lo; Zoccoli, Giovanna; Cenacchi, Giovanna; Trazzi, Stefania; Bergamini, Christian; Ciani, Elisabetta | 2023-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | 2023, Cardiac Functional and Structural Abnormalities, Loi-Bastianini.pdf; ijms-24-05552-s001.zip |
| Early-onset brain alterations during postnatal development in a mouse model of CDKL5 deficiency disorder | Tassinari, Marianna; Uguagliati, Beatrice; Trazzi, Stefania; Cerchier, Camilla Bruna; Cavina, Ott...avia Vera; Mottolese, Nicola; Loi, Manuela; Candini, Giulia; Medici, Giorgio; Ciani, Elisabetta | 2023-01-01 | NEUROBIOLOGY OF DISEASE | - | 1.01 Articolo in rivista | 2023, Early-onset brain alterations during postnatal development in a mouse, Tassinari-Uguagliati.pdf; ScienceDirect_files_24Jul2023_10-41-05.864.zip |
| Voluntary Running Improves Behavioral and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder | Mottolese, Nicola; Uguagliati, Beatrice; Tassinari, Marianna; Cerchier, Camilla Bruna; Loi, Manue...la; Candini, Giulia; Rimondini, Roberto; Medici, Giorgio; Trazzi, Stefania; Ciani, Elisabetta | 2023-01-01 | BIOMOLECULES | - | 1.01 Articolo in rivista | biomolecules-13-01396.pdf |
| Expression of a Secretable, Cell-Penetrating CDKL5 Protein Enhances the Efficacy of Gene Therapy for CDKL5 Deficiency Disorder | Medici, Giorgio; Tassinari, Marianna; Galvani, Giuseppe; Bastianini, Stefano; Gennaccaro, Laura; ...Loi, Manuela; Mottolese, Nicola; Alvente, Sara; Berteotti, Chiara; Sagona, Giulia; Lupori, Leonardo; Candini, Giulia; Baggett, Helen Rappe; Zoccoli, Giovanna; Giustetto, Maurizio; Muotri, Alysson; Pizzorusso, Tommaso; Nakai, Hiroyuki; Trazzi, Stefania; Ciani, Elisabetta | 2022-01-01 | NEUROTHERAPEUTICS | - | 1.01 Articolo in rivista | s13311-022-01295-8.pdf; supplemantary materials.zip |
| Luteolin Treatment Ameliorates Brain Development and Behavioral Performance in a Mouse Model of CDKL5 Deficiency Disorder | Tassinari, Marianna; Mottolese, Nicola; Galvani, Giuseppe; Ferrara, Domenico; Gennaccaro, Laura; ...Loi, Manuela; Medici, Giorgio; Candini, Giulia; Rimondini, Roberto; Ciani, Elisabetta; Trazzi, Stefania | 2022-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | ijms-23-08719.pdf; ijms-23-08719-s001.zip |
| A GABAB receptor antagonist rescues functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder | Laura Gennaccaro, Claudia Fuchs, Manuela Loi, Vincenzo Roncacè, Stefania Trazzi, Yassine Ait-Bali..., Giuseppe Galvani, Anna Cecilia Berardi, Giorgio Medici, Marianna Tassinari, Elisa Ren, Roberto Rimondini, Maurizio Giustetto, Giorgio Aicardi, Elisabetta Ciani | 2021-01-01 | NEUROBIOLOGY OF DISEASE | - | 1.01 Articolo in rivista | Gennaccaro et al 2021GABA.pdf; Supplementary data.docx |
| Age-related cognitive and motor decline in a mouse model of CDKL5 deficiency disorder is associated with increased neuronal senescence and death | Gennaccaro L.; Fuchs C.; Loi M.; Pizzo R.; Alvente S.; Berteotti C.; Lupori L.; Sagona G.; Galvan...i G.; Gurgone A.; Raspanti A.; Medici G.; Tassinari M.; Trazzi S.; Ren E.; Rimondini R.; Pizzorusso T.; Zoccoli G.; Giustetto M.; Ciani E. | 2021-01-01 | AGING AND DISEASE | - | 1.01 Articolo in rivista | Gennaccaro et al 2021Age.pdf |
| Inhibition of microglia over-activation restores neuronal survival and maturation in a mouse model of CDKL5 deficiency disorder | Nicola Mottolese, Giuseppe Galvani, Laura Gennaccaro, Manuela Loi, Giorgio Medici, Marianna Tassi...nari, Stefania Trazzi, Elisabetta Ciani | 2021-01-01 | - | - | 4.03 Poster | - |
| Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder | Galvani, Giuseppe; Mottolese, Nicola; Gennaccaro, Laura; Loi, Manuela; Medici, Giorgio; Tassinari..., Marianna; Fuchs, Claudia; Ciani, Elisabetta; Trazzi, Stefania | 2021-01-01 | JOURNAL OF NEUROINFLAMMATION | - | 1.01 Articolo in rivista | Galvani et al 2021.pdf |
| Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of CDKL5 Deficiency Disorder | Loi, Manuela; Gennaccaro, Laura; Fuchs, Claudia; Trazzi, Stefania; Medici, Giorgio; Galvani, Gius...eppe; Mottolese, Nicola; Tassinari, Marianna; Giorgini, Roberto Rimondini; Milelli, Andrea; Ciani, Elisabetta | 2021-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | Loi et al 2021.pdf; ijms-1212824-supplementary.pdf |
| Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons | Loi M.; Trazzi S.; Fuchs C.; Galvani G.; Medici G.; Gennaccaro L.; Tassinari M.; Ciani E. | 2020-01-01 | MOLECULAR NEUROBIOLOGY | - | 1.01 Articolo in rivista | - |
| Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models | Zaghini A.; Sarli G.; Barboni C.; Sanapo M.; Pellegrino V.; Diana A.; Linta N.; Rambaldi J.; D'Ap...ice M.R.; Murdocca M.; Baleani M.; Baruffaldi F.; Fognani R.; Mecca R.; Festa A.; Papparella S.; Paciello O.; Prisco F.; Capanni C.; Loi M.; Schena E.; Lattanzi G.; Squarzoni S. | 2020-01-01 | EXPERIMENTAL GERONTOLOGY | - | 1.01 Articolo in rivista | Progerie - lavoro colonie.pdf |
| Pharmacotherapy with sertraline rescues brain development and behavior in a mouse model of CDKL5 deficiency disorder | Fuchs C.; Gennaccaro L.; Ren E.; Galvani G.; Trazzi S.; Medici G.; Loi M.; Conway E.; Devinsky O....; Rimondini R.; Ciani E. | 2020-01-01 | NEUROPHARMACOLOGY | - | 1.01 Articolo in rivista | - |
| Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning | Pellegrini C.; Columbaro M.; Schena E.; Prencipe S.; Andrenacci D.; Iozzo P.; Angela Guzzardi M.;... Capanni C.; Mattioli E.; Loi M.; Araujo-Vilar D.; Squarzoni S.; Cinti S.; Morselli P.; Giorgetti A.; Zanotti L.; Gambineri A.; Lattanzi G. | 2019-01-01 | EXPERIMENTAL AND MOLECULAR MEDICINE | - | 1.01 Articolo in rivista | Pellegrini 2019 Altered adipocyte.pdf |
| CDKL5 deficiency predisposes neurons to cell death through the deregulation of SMAD3 signaling (vol 29, pg 658, 2019) | Fuchs C.; Medici G.; Trazzi S.; Gennaccaro L.; Galvani G.; Berteotti C.; Ren E.; Loi M.; Ciani E. | 2019-01-01 | BRAIN PATHOLOGY | - | 1.01 Articolo in rivista | - |
| Functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder are rescued by a TrkB agonist | Ren E.; Roncace V.; Trazzi S.; Fuchs C.; Medici G.; Gennaccaro L.; Loi M.; Galvani G.; Ye K.; Rim...ondini R.; Aicardi G.; Ciani E. | 2019-01-01 | FRONTIERS IN CELLULAR NEUROSCIENCE | - | 1.01 Articolo in rivista | fncel-13-00169.pdf |