MEDICI, GIORGIO
MEDICI, GIORGIO
DIBINEM - DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE
Ricercatori a tempo determinato
Adult-Onset Deletion of CDKL5 in Forebrain Glutamatergic Neurons Impairs Synaptic Integrity and Behavior in Mice
2025 Mottolese, Nicola; Iannibelli, Feliciana; Candini, Giulia; Trebbi, Federica; Loi, Manuela; Bove, Angelica Marina; Medici, Giorgio; Xiong, Zhi-Qi; Ciani, Elisabetta; Trazzi, Stefania
Beneficial Antioxidant Effects of Coenzyme Q10 in In Vitro and In Vivo Models of CDKL5 Deficiency Disorder
2025 Loi, Manuela; Valenti, Francesca; Medici, Giorgio; Mottolese, Nicola; Candini, Giulia; Bove, ANGELICA MARINA; Trebbi, Federica; Pincigher, Luca; Fato, Romana; Bergamini, Christian; Trazzi, Stefania; Ciani, Elisabetta
Lactic acid bacteria as microbial cell factories for the in vivo delivery of therapeutic proteins as secretable TAT fusion products
2025 Medici, Giorgio; Candini, Giulia; Mottolese, Nicola; Uguagliati, Beatrice; Trebbi, Federica; Loi, Manuela; Bove, Angelica Marina; Stojanov, Spase; Esposito, Erika; Vitagliano, Rosalba; D'Amico, Federica; Turroni, Silvia; Fiori, Jessica; Berlec, Aleš; Trazzi, Stefania; Ciani, Elisabetta
Safety and efficacy of Igk-TATk-CDKL5 gene therapy in mosaic CDKL5 deficiency
2025 Medici, Giorgio; Tassinari, Marianna; Loi, Manuela; Bove, Angelica Marina; Garofani, Beatrice Casadei; Volpedo, Greta; Mottolese, Nicola; Matteoli, Gabriele; Lo Martire, Viviana; Berteotti, Chiara; Candini, Giulia; Trebbi, Federica; Riva, Antonella; Striano, Pasquale; Zoccoli, Giovanna; Curia, Giulia; Trazzi, Stefania; Ciani, Elisabetta
Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5
2024 Matteoli, G.; Alvente, S.; Bastianini, S.; Berteotti, C.; Ciani, E.; Cinelli, E.; Lo Martire, V.; Medici, G.; Mello, T.; Miglioranza, E.; Silvani, A.; Mutolo, D.; Zoccoli, G.
Effects of a ciliary neurotrophic factor (CNTF) small-molecule peptide mimetic in an in vitro and in vivo model of CDKL5 deficiency disorder
2024 Mottolese, Nicola; Loi, Manuela; Trazzi, Stefania; Tassinari, Marianna; Uguagliati, Beatrice; Candini, Giulia; Iqbal, Khalid; Medici, Giorgio; Ciani, Elisabetta
Cardiac Functional and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder
2023 Loi, Manuela; Bastianini, Stefano; Candini, Giulia; Rizzardi, Nicola; Medici, Giorgio; Papa, Valentina; Gennaccaro, Laura; Mottolese, Nicola; Tassinari, Marianna; Uguagliati, Beatrice; Berteotti, Chiara; Martire, Viviana Lo; Zoccoli, Giovanna; Cenacchi, Giovanna; Trazzi, Stefania; Bergamini, Christian; Ciani, Elisabetta
Early-onset brain alterations during postnatal development in a mouse model of CDKL5 deficiency disorder
2023 Tassinari, Marianna; Uguagliati, Beatrice; Trazzi, Stefania; Cerchier, Camilla Bruna; Cavina, Ottavia Vera; Mottolese, Nicola; Loi, Manuela; Candini, Giulia; Medici, Giorgio; Ciani, Elisabetta
Voluntary Running Improves Behavioral and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder
2023 Mottolese, Nicola; Uguagliati, Beatrice; Tassinari, Marianna; Cerchier, Camilla Bruna; Loi, Manuela; Candini, Giulia; Rimondini, Roberto; Medici, Giorgio; Trazzi, Stefania; Ciani, Elisabetta
Artificial protein and its applications
2022 Alessandro Silvani; Giuseppe Plazzi; Giorgio Medici; Stefania Trazzi; Elisabetta Ciani; Gabriele Matteoli; Sara Alvente; Viviana Lo Martire; Stefano Bastianini; Chiara Berteotti; Giovanna Zoccoli
Expression of a Secretable, Cell-Penetrating CDKL5 Protein Enhances the Efficacy of Gene Therapy for CDKL5 Deficiency Disorder
2022 Medici, Giorgio; Tassinari, Marianna; Galvani, Giuseppe; Bastianini, Stefano; Gennaccaro, Laura; Loi, Manuela; Mottolese, Nicola; Alvente, Sara; Berteotti, Chiara; Sagona, Giulia; Lupori, Leonardo; Candini, Giulia; Baggett, Helen Rappe; Zoccoli, Giovanna; Giustetto, Maurizio; Muotri, Alysson; Pizzorusso, Tommaso; Nakai, Hiroyuki; Trazzi, Stefania; Ciani, Elisabetta
Luteolin Treatment Ameliorates Brain Development and Behavioral Performance in a Mouse Model of CDKL5 Deficiency Disorder
2022 Tassinari, Marianna; Mottolese, Nicola; Galvani, Giuseppe; Ferrara, Domenico; Gennaccaro, Laura; Loi, Manuela; Medici, Giorgio; Candini, Giulia; Rimondini, Roberto; Ciani, Elisabetta; Trazzi, Stefania
Treatment with FRAX486 rescues neurobehavioral and metabolic alterations in a female mouse model of CDKL5 deficiency disorder
2022 Fuchs, Claudia; Cosentino, Livia; Urbinati, Chiara; Talamo, Maria Cristina; Medici, Giorgio; Quattrini, Maria Cristina; Mottolese, Nicola; Pietraforte, Donatella; Fuso, Andrea; Ciani, Elisabetta; De Filippis, Bianca
A GABAB receptor antagonist rescues functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder
2021 Laura Gennaccaro, Claudia Fuchs, Manuela Loi, Vincenzo Roncacè, Stefania Trazzi, Yassine Ait-Bali, Giuseppe Galvani, Anna Cecilia Berardi, Giorgio Medici, Marianna Tassinari, Elisa Ren, Roberto Rimondini, Maurizio Giustetto, Giorgio Aicardi, Elisabetta Ciani
Age-related cognitive and motor decline in a mouse model of CDKL5 deficiency disorder is associated with increased neuronal senescence and death
2021 Gennaccaro L.; Fuchs C.; Loi M.; Pizzo R.; Alvente S.; Berteotti C.; Lupori L.; Sagona G.; Galvani G.; Gurgone A.; Raspanti A.; Medici G.; Tassinari M.; Trazzi S.; Ren E.; Rimondini R.; Pizzorusso T.; Zoccoli G.; Giustetto M.; Ciani E.
Inhibition of microglia over-activation restores neuronal survival and maturation in a mouse model of CDKL5 deficiency disorder
2021 Nicola Mottolese, Giuseppe Galvani, Laura Gennaccaro, Manuela Loi, Giorgio Medici, Marianna Tassinari, Stefania Trazzi, Elisabetta Ciani
Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder
2021 Galvani, Giuseppe; Mottolese, Nicola; Gennaccaro, Laura; Loi, Manuela; Medici, Giorgio; Tassinari, Marianna; Fuchs, Claudia; Ciani, Elisabetta; Trazzi, Stefania
Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of CDKL5 Deficiency Disorder
2021 Loi, Manuela; Gennaccaro, Laura; Fuchs, Claudia; Trazzi, Stefania; Medici, Giorgio; Galvani, Giuseppe; Mottolese, Nicola; Tassinari, Marianna; Giorgini, Roberto Rimondini; Milelli, Andrea; Ciani, Elisabetta
Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons
2020 Loi, M.; Trazzi, S.; Fuchs, C.; Galvani, G.; Medici, G.; Gennaccaro, L.; Tassinari, M.; Ciani, E.
Pharmacotherapy with sertraline rescues brain development and behavior in a mouse model of CDKL5 deficiency disorder
2020 Fuchs, C.; Gennaccaro, L.; Ren, E.; Galvani, G.; Trazzi, S.; Medici, G.; Loi, M.; Conway, E.; Devinsky, O.; Rimondini, R.; Ciani, E.
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| Adult-Onset Deletion of CDKL5 in Forebrain Glutamatergic Neurons Impairs Synaptic Integrity and Behavior in Mice | Mottolese, Nicola; Iannibelli, Feliciana; Candini, Giulia; Trebbi, Federica; Loi, Manuela; Bove, ...Angelica Marina; Medici, Giorgio; Xiong, Zhi-Qi; Ciani, Elisabetta; Trazzi, Stefania | 2025-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | ijms-26-06626-manuscript.pdf; ijms-3733101-supplementary.pdf |
| Beneficial Antioxidant Effects of Coenzyme Q10 in In Vitro and In Vivo Models of CDKL5 Deficiency Disorder | Loi, Manuela; Valenti, Francesca; Medici, Giorgio; Mottolese, Nicola; Candini, Giulia; Bove, ANGE...LICA MARINA; Trebbi, Federica; Pincigher, Luca; Fato, Romana; Bergamini, Christian; Trazzi, Stefania; Ciani, Elisabetta | 2025-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | ijms-26-02204-v3.pdf; ijms-26-02204-s001.zip |
| Lactic acid bacteria as microbial cell factories for the in vivo delivery of therapeutic proteins as secretable TAT fusion products | Medici, Giorgio; Candini, Giulia; Mottolese, Nicola; Uguagliati, Beatrice; Trebbi, Federica; Loi,... Manuela; Bove, Angelica Marina; Stojanov, Spase; Esposito, Erika; Vitagliano, Rosalba; D'Amico, Federica; Turroni, Silvia; Fiori, Jessica; Berlec, Aleš; Trazzi, Stefania; Ciani, Elisabetta | 2025-01-01 | JOURNAL OF BIOLOGICAL ENGINEERING | - | 1.01 Articolo in rivista | 13036_2025_Article_538.pdf; 13036_2025_538_MOESM1_ESM.pdf |
| Safety and efficacy of Igk-TATk-CDKL5 gene therapy in mosaic CDKL5 deficiency | Medici, Giorgio; Tassinari, Marianna; Loi, Manuela; Bove, Angelica Marina; Garofani, Beatrice Cas...adei; Volpedo, Greta; Mottolese, Nicola; Matteoli, Gabriele; Lo Martire, Viviana; Berteotti, Chiara; Candini, Giulia; Trebbi, Federica; Riva, Antonella; Striano, Pasquale; Zoccoli, Giovanna; Curia, Giulia; Trazzi, Stefania; Ciani, Elisabetta | 2025-01-01 | NEUROTHERAPEUTICS | - | 1.01 Articolo in rivista | - |
| Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5 | Matteoli, G.; Alvente, S.; Bastianini, S.; Berteotti, C.; Ciani, E.; Cinelli, E.; Lo Martire, V.;... Medici, G.; Mello, T.; Miglioranza, E.; Silvani, A.; Mutolo, D.; Zoccoli, G. | 2024-01-01 | JOURNAL OF SLEEP RESEARCH | - | 1.01 Articolo in rivista | Matteoli2024.pdf |
| Effects of a ciliary neurotrophic factor (CNTF) small-molecule peptide mimetic in an in vitro and in vivo model of CDKL5 deficiency disorder | Mottolese, Nicola; Loi, Manuela; Trazzi, Stefania; Tassinari, Marianna; Uguagliati, Beatrice; Can...dini, Giulia; Iqbal, Khalid; Medici, Giorgio; Ciani, Elisabetta | 2024-01-01 | JOURNAL OF NEURODEVELOPMENTAL DISORDERS | - | 1.01 Articolo in rivista | Mottolese et al., 2024_JNDD_Manuscript.pdf |
| Cardiac Functional and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder | Loi, Manuela; Bastianini, Stefano; Candini, Giulia; Rizzardi, Nicola; Medici, Giorgio; Papa, Vale...ntina; Gennaccaro, Laura; Mottolese, Nicola; Tassinari, Marianna; Uguagliati, Beatrice; Berteotti, Chiara; Martire, Viviana Lo; Zoccoli, Giovanna; Cenacchi, Giovanna; Trazzi, Stefania; Bergamini, Christian; Ciani, Elisabetta | 2023-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | 2023, Cardiac Functional and Structural Abnormalities, Loi-Bastianini.pdf; ijms-24-05552-s001.zip |
| Early-onset brain alterations during postnatal development in a mouse model of CDKL5 deficiency disorder | Tassinari, Marianna; Uguagliati, Beatrice; Trazzi, Stefania; Cerchier, Camilla Bruna; Cavina, Ott...avia Vera; Mottolese, Nicola; Loi, Manuela; Candini, Giulia; Medici, Giorgio; Ciani, Elisabetta | 2023-01-01 | NEUROBIOLOGY OF DISEASE | - | 1.01 Articolo in rivista | 2023, Early-onset brain alterations during postnatal development in a mouse, Tassinari-Uguagliati.pdf; ScienceDirect_files_24Jul2023_10-41-05.864.zip |
| Voluntary Running Improves Behavioral and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder | Mottolese, Nicola; Uguagliati, Beatrice; Tassinari, Marianna; Cerchier, Camilla Bruna; Loi, Manue...la; Candini, Giulia; Rimondini, Roberto; Medici, Giorgio; Trazzi, Stefania; Ciani, Elisabetta | 2023-01-01 | BIOMOLECULES | - | 1.01 Articolo in rivista | biomolecules-13-01396.pdf |
| Artificial protein and its applications | Alessandro Silvani; Giuseppe Plazzi; Giorgio Medici; Stefania Trazzi; Elisabetta Ciani; Gabriele ...Matteoli; Sara Alvente; Viviana Lo Martire; Stefano Bastianini; Chiara Berteotti; Giovanna Zoccoli | 2022-01-01 | - | - | 6.01 Brevetto | - |
| Expression of a Secretable, Cell-Penetrating CDKL5 Protein Enhances the Efficacy of Gene Therapy for CDKL5 Deficiency Disorder | Medici, Giorgio; Tassinari, Marianna; Galvani, Giuseppe; Bastianini, Stefano; Gennaccaro, Laura; ...Loi, Manuela; Mottolese, Nicola; Alvente, Sara; Berteotti, Chiara; Sagona, Giulia; Lupori, Leonardo; Candini, Giulia; Baggett, Helen Rappe; Zoccoli, Giovanna; Giustetto, Maurizio; Muotri, Alysson; Pizzorusso, Tommaso; Nakai, Hiroyuki; Trazzi, Stefania; Ciani, Elisabetta | 2022-01-01 | NEUROTHERAPEUTICS | - | 1.01 Articolo in rivista | s13311-022-01295-8.pdf; supplemantary materials.zip |
| Luteolin Treatment Ameliorates Brain Development and Behavioral Performance in a Mouse Model of CDKL5 Deficiency Disorder | Tassinari, Marianna; Mottolese, Nicola; Galvani, Giuseppe; Ferrara, Domenico; Gennaccaro, Laura; ...Loi, Manuela; Medici, Giorgio; Candini, Giulia; Rimondini, Roberto; Ciani, Elisabetta; Trazzi, Stefania | 2022-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | ijms-23-08719.pdf; ijms-23-08719-s001.zip |
| Treatment with FRAX486 rescues neurobehavioral and metabolic alterations in a female mouse model of CDKL5 deficiency disorder | Fuchs, Claudia; Cosentino, Livia; Urbinati, Chiara; Talamo, Maria Cristina; Medici, Giorgio; Quat...trini, Maria Cristina; Mottolese, Nicola; Pietraforte, Donatella; Fuso, Andrea; Ciani, Elisabetta; De Filippis, Bianca | 2022-01-01 | CNS NEUROSCIENCE & THERAPEUTICS | - | 1.01 Articolo in rivista | CNS-28-1718.pdf; file supplementare.zip |
| A GABAB receptor antagonist rescues functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder | Laura Gennaccaro, Claudia Fuchs, Manuela Loi, Vincenzo Roncacè, Stefania Trazzi, Yassine Ait-Bali..., Giuseppe Galvani, Anna Cecilia Berardi, Giorgio Medici, Marianna Tassinari, Elisa Ren, Roberto Rimondini, Maurizio Giustetto, Giorgio Aicardi, Elisabetta Ciani | 2021-01-01 | NEUROBIOLOGY OF DISEASE | - | 1.01 Articolo in rivista | Gennaccaro et al 2021GABA.pdf; Supplementary data.docx |
| Age-related cognitive and motor decline in a mouse model of CDKL5 deficiency disorder is associated with increased neuronal senescence and death | Gennaccaro L.; Fuchs C.; Loi M.; Pizzo R.; Alvente S.; Berteotti C.; Lupori L.; Sagona G.; Galvan...i G.; Gurgone A.; Raspanti A.; Medici G.; Tassinari M.; Trazzi S.; Ren E.; Rimondini R.; Pizzorusso T.; Zoccoli G.; Giustetto M.; Ciani E. | 2021-01-01 | AGING AND DISEASE | - | 1.01 Articolo in rivista | Gennaccaro et al 2021Age.pdf |
| Inhibition of microglia over-activation restores neuronal survival and maturation in a mouse model of CDKL5 deficiency disorder | Nicola Mottolese, Giuseppe Galvani, Laura Gennaccaro, Manuela Loi, Giorgio Medici, Marianna Tassi...nari, Stefania Trazzi, Elisabetta Ciani | 2021-01-01 | - | - | 4.03 Poster | - |
| Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder | Galvani, Giuseppe; Mottolese, Nicola; Gennaccaro, Laura; Loi, Manuela; Medici, Giorgio; Tassinari..., Marianna; Fuchs, Claudia; Ciani, Elisabetta; Trazzi, Stefania | 2021-01-01 | JOURNAL OF NEUROINFLAMMATION | - | 1.01 Articolo in rivista | Galvani et al 2021.pdf |
| Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of CDKL5 Deficiency Disorder | Loi, Manuela; Gennaccaro, Laura; Fuchs, Claudia; Trazzi, Stefania; Medici, Giorgio; Galvani, Gius...eppe; Mottolese, Nicola; Tassinari, Marianna; Giorgini, Roberto Rimondini; Milelli, Andrea; Ciani, Elisabetta | 2021-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | Loi et al 2021.pdf; ijms-1212824-supplementary.pdf |
| Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons | Loi, M.; Trazzi, S.; Fuchs, C.; Galvani, G.; Medici, G.; Gennaccaro, L.; Tassinari, M.; Ciani, E. | 2020-01-01 | MOLECULAR NEUROBIOLOGY | - | 1.01 Articolo in rivista | Loi et al.pdf; 12035_2020_1884_MOESM1_ESM.pdf |
| Pharmacotherapy with sertraline rescues brain development and behavior in a mouse model of CDKL5 deficiency disorder | Fuchs, C.; Gennaccaro, L.; Ren, E.; Galvani, G.; Trazzi, S.; Medici, G.; Loi, M.; Conway, E.; Dev...insky, O.; Rimondini, R.; Ciani, E. | 2020-01-01 | NEUROPHARMACOLOGY | - | 1.01 Articolo in rivista | - |