PERINI, GIOVANNI
PERINI, GIOVANNI
FABIT - DIPARTIMENTO DI FARMACIA E BIOTECNOLOGIE
Docenti di ruolo di Ia fascia
Gene selection for prediction of transcriptome signal based on a machine learning approach
2025 Demurtas, Pietro; Bertozzi, Jacopo; Di Silvestro, Irene; Carlin, Kevin; Ghetti, Andre; Krause, Brian; Perini, Giovanni; Zanchetta, Ferdinando; Fioresi, Rita
Non-canonical activating roles of RCoR2 sustain transcription in adrenergic neuroblastoma
2025 Aloisi, Sara; Santulli, Martina; Russo, Marco; Zadran, Suleman K; Rigamonti, Alberto; Chin, Diana H; Palombo, Marta; Cimadom, Leonardo; Scrofani, Lorenzo; Bernardoni, Roberto; Capranico, Giovanni; Gryder, Berkley E; Perini, Giovanni; Milazzo, Giorgio
Systematic Targeting of GD2‐Positive Neuroblastoma Tumors With a Photooncolytic Phage Nanovector Platform
2025 Zadran, Suleman Khan; Facchinello, Nicola; De Rosa, Piergiuseppe; Saporetti, Roberto; Costantini, Paolo Emidio; Ulfo, Luca; Nigro, Michela; Petrosino, Annapaola; Pappagallo, Lucia; Aloisi, Sara; Milazzo, Giorgio; Din, Zainul Abe; Rigamonti, Alberto; Flora, Leonardo; Santulli, Martina; Cimadom, Leonardo; Zuccheri, Giampaolo; Zangoli, Mattia; Sante, Manuele Di; Giosia, Matteo Di; Maria, Francesca Di; Bernardoni, Roberto; Barbieri, Eveline; Calvaresi, Matteo; Danielli, Alberto; Perini, Giovanni
The cell-permeable iron chelator M606 inhibits MYCN-driven neuroblastoma via an E2F3-mediated response
2025 Pandher, R.; Xue, C.; Gamble, L. D.; Milazzo, G.; Giacomo, S. D.; Murray, J.; Cheung, L.; Ferrucci, F.; Palombo, M.; Purgato, S.; Burkhart, C. A.; Fedtsova, N.; Gleiberman, A. S.; Purmal, A. A.; Korotchkina, L.; Nikiforov, M. A.; Makarov, S. S.; Telfer, T. J.; Codd, R.; Marshall, G. M.; Scott, D. A.; Osterman, A. L.; Gudkov, A. V.; Perini, G.; Haber, M.; Norris, M. D.
The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis
2024 Murray, J. E.; Valli, E.; Milazzo, G.; Mayoh, C.; Gifford, A. J.; Fletcher, J. I.; Xue, C.; Jayatilleke, N.; Salehzadeh, F.; Gamble, L. D.; Rouaen, J. R. C.; Carter, D. R.; Forgham, H.; Sekyere, E. O.; Keating, J.; Eden, G.; Allan, S.; Alfred, S.; Kusuma, F. K.; Clark, A.; Webber, H.; Russell, A. J.; de Weck, A.; Kile, B. T.; Santulli, M.; De Rosa, P.; Fleuren, E. D. G.; Gao, W.; Wilkinson-White, L.; Low, J. K. K.; Mackay, J. P.; Marshall, G. M.; Hilton, D. J.; Giorgi, F. M.; Koster, J.; Perini, G.; Haber, M.; Norris, M. D.
MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors’ Efficacy in Neuroblastoma Cells
2023 De Rosa P.; Severi F.; Zadran S.K.; Russo M.; Aloisi S.; Rigamonti A.; Capranico G.; Milazzo G.; Perini G.
Deep learning for MYC binding site recognition
2022 Fioresi, R.; Demurtas, P.; Perini, G.
MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma
2022 Tao L.; Mohammad M.A.; Milazzo G.; Moreno-Smith M.; Patel T.D.; Zorman B.; Badachhape A.; Hernandez B.E.; Wolf A.B.; Zeng Z.; Foster J.H.; Aloisi S.; Sumazin P.; Zu Y.; Hicks J.; Ghaghada K.B.; Putluri N.; Perini G.; Coarfa C.; Barbieri E.
Single-Cell Sequencing Identifies Master Regulators Affected by Panobinostat in Neuroblastoma Cells
2022 Milazzo G.; Perini G.; Giorgi F.M.
A g316a polymorphism in the ornithine decarboxylase gene promoter modulates mycn‐driven childhood neuroblastoma
2021 Gamble L.D.; Purgato S.; Henderson M.J.; Di Giacomo S.; Russell A.J.; Pigini P.; Murray J.; Valli E.; Milazzo G.; Giorgi F.M.; Cowley M.; Ashton L.J.; Bhalshankar J.; Schleiermacher G.; Rihani A.; Van Maerken T.; Vandesompele J.; Speleman F.; Versteeg R.; Koster J.; Eggert A.; Noguera R.; Stallings R.L.; Tonini G.P.; Fong K.; Vaksman Z.; Diskin S.J.; Maris J.M.; London W.B.; Marshall G.M.; Ziegler D.S.; Hogarty M.D.; Perini G.; Norris M.D.; Haber M.
CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming
2021 Tao L.; Moreno-Smith M.; Ibarra-Garcia-Padilla R.; Milazzo G.; Drolet N.A.; Hernandez B.E.; Oh Y.S.; Patel I.; Kim J.J.; Zorman B.; Patel T.; Kamal A.H.M.; Zhao Y.; Hicks J.; Vasudevan S.A.; Putluri N.; Coarfa C.; Sumazin P.; Perini G.; Parchem R.J.; Uribe R.A.; Barbieri E.
Restoration of the molecular clock is tumor suppressive in neuroblastoma
2021 Moreno-Smith M.; Milazzo G.; Tao L.; Fekry B.; Zhu B.; Mohammad M.A.; Di Giacomo S.; Borkar R.; Reddy K.R.K.; Capasso M.; Vasudevan S.A.; Sumazin P.; Hicks J.; Putluri N.; Perini G.; Eckel-Mahan K.; Burris T.P.; Barbieri E.
Single-cell gene network analysis and transcriptional landscape of MYCN-amplified neuroblastoma cell lines
2021 Mercatelli D.; Balboni N.; Palma A.; Aleo E.; Sanna P.P.; Perini G.; Giorgi F.M.
Targeting oncogenic transcriptional networks in neuroblastoma: From N-Myc to epigenetic drugs
2021 Ciaccio R.; De Rosa P.; Aloisi S.; Viggiano M.; Cimadom L.; Zadran S.K.; Perini G.; Milazzo G.
Histone deacetylases (HDACs): Evolution, specificity, role in transcriptional complexes, and pharmacological actionability
2020 Milazzo G.; Mercatelli D.; Di Muzio G.; Triboli L.; De Rosa P.; Perini G.; Giorgi F.M.
PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis
2020 Mzoughi, Slim; Fong, Jia Yi; Papadopoli, David; Koh, Cheryl M; Hulea, Laura; Pigini, Paolo; Di Tullio, Federico; Andreacchio, Giuseppe; Hoppe, Michal Marek; Wollmann, Heike; Low, Diana; Caldez, Matias J; Peng, Yanfen; Torre, Denis; Zhao, Julia N; Uchenunu, Oro; Varano, Gabriele; Motofeanu, Corina-Mihaela; Lakshmanan, Manikandan; Teo, Shun Xie; Wun, Cheng Mun; Perini, Giovanni; Tan, Soo Yong; Ong, Chee Bing; Al-Haddawi, Muthafar; Rajarethinam, Ravisankar; Hue, Susan Swee-Shan; Lim, Soon Thye; Ong, Choon Kiat; Huang, Dachuan; Ng, Siok-Bian; Bernstein, Emily; Hasson, Dan; Wee, Keng Boon; Kaldis, Philipp; Jeyasekharan, Anand; Dominguez-Sola, David; Topisirovic, Ivan; Guccione, Ernesto
Repurposing a psychoactive drug for children with cancer: p27 Kip1-dependent inhibition of metastatic neuroblastomas by Prozac
2020 Bibbo' S.; Lamolinara A.; Capone E.; Purgato S.; Tsakaneli A.; Panella V.; Sallese M.; Rossi C.; Ciufici P.; Nieddu V.; De Laurenzi V.; Iezzi M.; Perini G.; Sala G.; Sala A.
A new BCR-ABL1 Drosophila model as a powerful tool to elucidate pathogenesis and progression of chronic myeloid leukemia
2019 Roberto Bernardoni, Giorgia Giordani, Elisabetta Signorino, Sara Monticelli, Francesca Messa, Monica Pradotto, Valentina Rosso, Enrico Bracco, Angela Giangrande, Giovanni Perini, Giuseppe Saglio, Daniela Cilloni
Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface
2019 Koach, Jessica; Holien, Jessica K; Massudi, Hassina; Carter, Daniel R; Ciampa, Olivia C; Herath, Mika; Lim, Taylor; Seneviratne, Janith A; Milazzo, Giorgio; Murray, Jayne E; McCarroll, Joshua A; Liu, Bing; Mayoh, Chelsea; Keenan, Bryce; Stevenson, Brendan W; Gorman, Michael A; Bell, Jessica L; Doughty, Larissa; Hüttelmaier, Stefan; Oberthuer, Andre; Fischer, Matthias; Gifford, Andrew J; Liu, Tao; Zhang, Xiaoling; Zhu, Shizhen; Gustafson, W Clay; Haber, Michelle; Norris, Murray D; Fletcher, Jamie I; Perini, Giovanni; Parker, Michael W; Cheung, Belamy B; Marshall, Glenn M
Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma
2019 Laura D. Gamble, Stefania Purgato, Jayne Murray, Lin Xiao, Denise M. T. Yu, Kimberley M. Hanssen, Federico M. Giorgi, Daniel R. Carter, Andrew J. Gifford, Emanuele Valli, Giorgio Milazzo, Alvin Kamili, Chelsea Mayoh, Bing Liu, Georgina Eden, Sara Sarraf, Sophie Allan, Simone Di Giacomo, Claudia L. Flemming, Amanda J. Russell, Belamy B. Cheung, Andre Oberthuer, Wendy B. London, Matthias Fischer, Toby N. Trahair, Jamie I. Fletcher, Glenn M. Marshall, David S. Ziegler, Michael D. Hogarty, Mark R. Burns, Giovanni Perini, Murray D. Norris, and Michelle Haber
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| Gene selection for prediction of transcriptome signal based on a machine learning approach | Demurtas, Pietro; Bertozzi, Jacopo; Di Silvestro, Irene; Carlin, Kevin; Ghetti, Andre; Krause, Br...ian; Perini, Giovanni; Zanchetta, Ferdinando; Fioresi, Rita | 2025-01-01 | DISCOVER APPLIED SCIENCES | - | 1.01 Articolo in rivista | Gene_selection_for_prediction_of_transcriptome_sig.pdf |
| Non-canonical activating roles of RCoR2 sustain transcription in adrenergic neuroblastoma | Aloisi, Sara; Santulli, Martina; Russo, Marco; Zadran, Suleman K; Rigamonti, Alberto; Chin, Diana... H; Palombo, Marta; Cimadom, Leonardo; Scrofani, Lorenzo; Bernardoni, Roberto; Capranico, Giovanni; Gryder, Berkley E; Perini, Giovanni; Milazzo, Giorgio | 2025-01-01 | CELL REPORTS | - | 1.01 Articolo in rivista | Aloisi et al_Cell reports_2025.pdf |
| Systematic Targeting of GD2‐Positive Neuroblastoma Tumors With a Photooncolytic Phage Nanovector Platform | Zadran, Suleman Khan; Facchinello, Nicola; De Rosa, Piergiuseppe; Saporetti, Roberto; Costantini,... Paolo Emidio; Ulfo, Luca; Nigro, Michela; Petrosino, Annapaola; Pappagallo, Lucia; Aloisi, Sara; Milazzo, Giorgio; Din, Zainul Abe; Rigamonti, Alberto; Flora, Leonardo; Santulli, Martina; Cimadom, Leonardo; Zuccheri, Giampaolo; Zangoli, Mattia; Sante, Manuele Di; Giosia, Matteo Di; Maria, Francesca Di; Bernardoni, Roberto; Barbieri, Eveline; Calvaresi, Matteo; Danielli, Alberto; Perini, Giovanni | 2025-01-01 | ADVANCED SCIENCE | - | 1.01 Articolo in rivista | AdvSci_Zadran_lite.pdf |
| The cell-permeable iron chelator M606 inhibits MYCN-driven neuroblastoma via an E2F3-mediated response | Pandher, R.; Xue, C.; Gamble, L. D.; Milazzo, G.; Giacomo, S. D.; Murray, J.; Cheung, L.; Ferrucc...i, F.; Palombo, M.; Purgato, S.; Burkhart, C. A.; Fedtsova, N.; Gleiberman, A. S.; Purmal, A. A.; Korotchkina, L.; Nikiforov, M. A.; Makarov, S. S.; Telfer, T. J.; Codd, R.; Marshall, G. M.; Scott, D. A.; Osterman, A. L.; Gudkov, A. V.; Perini, G.; Haber, M.; Norris, M. D. | 2025-01-01 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - | 1.01 Articolo in rivista | pandher-et-al-the-cell-permeable-iron-chelator-m606-inhibits-mycn-driven-neuroblastoma-via-an-e2f3-mediated-response.pdf |
| The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis | Murray, J. E.; Valli, E.; Milazzo, G.; Mayoh, C.; Gifford, A. J.; Fletcher, J. I.; Xue, C.; Jayat...illeke, N.; Salehzadeh, F.; Gamble, L. D.; Rouaen, J. R. C.; Carter, D. R.; Forgham, H.; Sekyere, E. O.; Keating, J.; Eden, G.; Allan, S.; Alfred, S.; Kusuma, F. K.; Clark, A.; Webber, H.; Russell, A. J.; de Weck, A.; Kile, B. T.; Santulli, M.; De Rosa, P.; Fleuren, E. D. G.; Gao, W.; Wilkinson-White, L.; Low, J. K. K.; Mackay, J. P.; Marshall, G. M.; Hilton, D. J.; Giorgi, F. M.; Koster, J.; Perini, G.; Haber, M.; Norris, M. D. | 2024-01-01 | NATURE COMMUNICATIONS | - | 1.01 Articolo in rivista | s41467-024-49871-0.pdf |
| MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors’ Efficacy in Neuroblastoma Cells | De Rosa P.; Severi F.; Zadran S.K.; Russo M.; Aloisi S.; Rigamonti A.; Capranico G.; Milazzo G.; ...Perini G. | 2023-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | ijms-24-05408-v2.pdf |
| Deep learning for MYC binding site recognition | Fioresi, R.; Demurtas, P.; Perini, G. | 2022-01-01 | FRONTIERS IN BIOINFORMATICS | - | 1.01 Articolo in rivista | - |
| MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma | Tao L.; Mohammad M.A.; Milazzo G.; Moreno-Smith M.; Patel T.D.; Zorman B.; Badachhape A.; Hernand...ez B.E.; Wolf A.B.; Zeng Z.; Foster J.H.; Aloisi S.; Sumazin P.; Zu Y.; Hicks J.; Ghaghada K.B.; Putluri N.; Perini G.; Coarfa C.; Barbieri E. | 2022-01-01 | NATURE COMMUNICATIONS | - | 1.01 Articolo in rivista | Liu T. et al.pdf |
| Single-Cell Sequencing Identifies Master Regulators Affected by Panobinostat in Neuroblastoma Cells | Milazzo G.; Perini G.; Giorgi F.M. | 2022-01-01 | GENES | - | 1.01 Articolo in rivista | genes-13-02240.pdf |
| A g316a polymorphism in the ornithine decarboxylase gene promoter modulates mycn‐driven childhood neuroblastoma | Gamble L.D.; Purgato S.; Henderson M.J.; Di Giacomo S.; Russell A.J.; Pigini P.; Murray J.; Valli... E.; Milazzo G.; Giorgi F.M.; Cowley M.; Ashton L.J.; Bhalshankar J.; Schleiermacher G.; Rihani A.; Van Maerken T.; Vandesompele J.; Speleman F.; Versteeg R.; Koster J.; Eggert A.; Noguera R.; Stallings R.L.; Tonini G.P.; Fong K.; Vaksman Z.; Diskin S.J.; Maris J.M.; London W.B.; Marshall G.M.; Ziegler D.S.; Hogarty M.D.; Perini G.; Norris M.D.; Haber M. | 2021-01-01 | CANCERS | - | 1.01 Articolo in rivista | cancers-13-01807-v2.pdf |
| CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming | Tao L.; Moreno-Smith M.; Ibarra-Garcia-Padilla R.; Milazzo G.; Drolet N.A.; Hernandez B.E.; Oh Y....S.; Patel I.; Kim J.J.; Zorman B.; Patel T.; Kamal A.H.M.; Zhao Y.; Hicks J.; Vasudevan S.A.; Putluri N.; Coarfa C.; Sumazin P.; Perini G.; Parchem R.J.; Uribe R.A.; Barbieri E. | 2021-01-01 | ADVANCED SCIENCE | - | 1.01 Articolo in rivista | Tao L et al.pdf |
| Restoration of the molecular clock is tumor suppressive in neuroblastoma | Moreno-Smith M.; Milazzo G.; Tao L.; Fekry B.; Zhu B.; Mohammad M.A.; Di Giacomo S.; Borkar R.; R...eddy K.R.K.; Capasso M.; Vasudevan S.A.; Sumazin P.; Hicks J.; Putluri N.; Perini G.; Eckel-Mahan K.; Burris T.P.; Barbieri E. | 2021-01-01 | NATURE COMMUNICATIONS | - | 1.01 Articolo in rivista | Myrthala Moreno-Smith et al.pdf |
| Single-cell gene network analysis and transcriptional landscape of MYCN-amplified neuroblastoma cell lines | Mercatelli D.; Balboni N.; Palma A.; Aleo E.; Sanna P.P.; Perini G.; Giorgi F.M. | 2021-01-01 | BIOMOLECULES | - | 1.01 Articolo in rivista | biomolecules-11-00177-v3.pdf |
| Targeting oncogenic transcriptional networks in neuroblastoma: From N-Myc to epigenetic drugs | Ciaccio R.; De Rosa P.; Aloisi S.; Viggiano M.; Cimadom L.; Zadran S.K.; Perini G.; Milazzo G. | 2021-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | Ciaccio et al.pdf |
| Histone deacetylases (HDACs): Evolution, specificity, role in transcriptional complexes, and pharmacological actionability | Milazzo G.; Mercatelli D.; Di Muzio G.; Triboli L.; De Rosa P.; Perini G.; Giorgi F.M. | 2020-01-01 | GENES | - | 1.01 Articolo in rivista | genes-11-00556-v2_compressed.pdf |
| PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis | Mzoughi, Slim; Fong, Jia Yi; Papadopoli, David; Koh, Cheryl M; Hulea, Laura; Pigini, Paolo; Di Tu...llio, Federico; Andreacchio, Giuseppe; Hoppe, Michal Marek; Wollmann, Heike; Low, Diana; Caldez, Matias J; Peng, Yanfen; Torre, Denis; Zhao, Julia N; Uchenunu, Oro; Varano, Gabriele; Motofeanu, Corina-Mihaela; Lakshmanan, Manikandan; Teo, Shun Xie; Wun, Cheng Mun; Perini, Giovanni; Tan, Soo Yong; Ong, Chee Bing; Al-Haddawi, Muthafar; Rajarethinam, Ravisankar; Hue, Susan Swee-Shan; Lim, Soon Thye; Ong, Choon Kiat; Huang, Dachuan; Ng, Siok-Bian; Bernstein, Emily; Hasson, Dan; Wee, Keng Boon; Kaldis, Philipp; Jeyasekharan, Anand; Dominguez-Sola, David; Topisirovic, Ivan; Guccione, Ernesto | 2020-01-01 | NATURE COMMUNICATIONS | - | 1.01 Articolo in rivista | 41467_2020_Article_17064.pdf |
| Repurposing a psychoactive drug for children with cancer: p27 Kip1-dependent inhibition of metastatic neuroblastomas by Prozac | Bibbo' S.; Lamolinara A.; Capone E.; Purgato S.; Tsakaneli A.; Panella V.; Sallese M.; Rossi C.; ...Ciufici P.; Nieddu V.; De Laurenzi V.; Iezzi M.; Perini G.; Sala G.; Sala A. | 2020-01-01 | ONCOGENESIS | - | 1.01 Articolo in rivista | s41389-019-0186-3.pdf |
| A new BCR-ABL1 Drosophila model as a powerful tool to elucidate pathogenesis and progression of chronic myeloid leukemia | Roberto Bernardoni, Giorgia Giordani, Elisabetta Signorino, Sara Monticelli, Francesca Messa, Mon...ica Pradotto, Valentina Rosso, Enrico Bracco, Angela Giangrande, Giovanni Perini, Giuseppe Saglio, Daniela Cilloni | 2019-01-01 | HAEMATOLOGICA | - | 1.01 Articolo in rivista | Bernardoni et al, 2019.pdf |
| Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface | Koach, Jessica; Holien, Jessica K; Massudi, Hassina; Carter, Daniel R; Ciampa, Olivia C; Herath, ...Mika; Lim, Taylor; Seneviratne, Janith A; Milazzo, Giorgio; Murray, Jayne E; McCarroll, Joshua A; Liu, Bing; Mayoh, Chelsea; Keenan, Bryce; Stevenson, Brendan W; Gorman, Michael A; Bell, Jessica L; Doughty, Larissa; Hüttelmaier, Stefan; Oberthuer, Andre; Fischer, Matthias; Gifford, Andrew J; Liu, Tao; Zhang, Xiaoling; Zhu, Shizhen; Gustafson, W Clay; Haber, Michelle; Norris, Murray D; Fletcher, Jamie I; Perini, Giovanni; Parker, Michael W; Cheung, Belamy B; Marshall, Glenn M | 2019-01-01 | CANCER RESEARCH | - | 1.01 Articolo in rivista | Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface.pdf |
| Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma | Laura D. Gamble, Stefania Purgato, Jayne Murray, Lin Xiao, Denise M. T. Yu, Kimberley M. Hanssen,... Federico M. Giorgi, Daniel R. Carter, Andrew J. Gifford, Emanuele Valli, Giorgio Milazzo, Alvin Kamili, Chelsea Mayoh, Bing Liu, Georgina Eden, Sara Sarraf, Sophie Allan, Simone Di Giacomo, Claudia L. Flemming, Amanda J. Russell, Belamy B. Cheung, Andre Oberthuer, Wendy B. London, Matthias Fischer, Toby N. Trahair, Jamie I. Fletcher, Glenn M. Marshall, David S. Ziegler, Michael D. Hogarty, Mark R. Burns, Giovanni Perini, Murray D. Norris, and Michelle Haber | 2019-01-01 | SCIENCE TRANSLATIONAL MEDICINE | - | 1.01 Articolo in rivista | - |