Intra-abdominal infections (IAIs) are an important cause of morbidity and mortality in hospital settings worldwide. The cornerstones of IAI management include rapid, accurate diagnostics; timely, adequate source control; appropriate, short-duration antimicrobial therapy administered according to the principles of pharmacokinetics/pharmacodynamics and antimicrobial stewardship; and hemodynamic and organ functional support with intravenous fluid and adjunctive vasopressor agents for critical illness (sepsis/organ dysfunction or septic shock after correction of hypovolemia). In patients with IAIs, a personalized approach is crucial to optimize outcomes and should be based on multiple aspects that require careful clinical assessment. The anatomic extent of infection, the presumed pathogens involved and risk factors for antimicrobial resistance, the origin and extent of the infection, the patient's clinical condition, and the host's immune status should be assessed continuously to optimize the management of patients with complicated IAIs.

Sartelli, M., Barie, P., Agnoletti, V., Al-Hasan, M.N., Ansaloni, L., Biffl, W., et al. (2024). Intra-abdominal infections survival guide: a position statement by the Global Alliance For Infections In Surgery. WORLD JOURNAL OF EMERGENCY SURGERY, 19(1), 1-20 [10.1186/s13017-024-00552-9].

Intra-abdominal infections survival guide: a position statement by the Global Alliance For Infections In Surgery

Agnoletti, Vanni;Leone, Marc;Vallicelli, Carlo;Catena, Fausto;Coccolini, Federico
2024

Abstract

Intra-abdominal infections (IAIs) are an important cause of morbidity and mortality in hospital settings worldwide. The cornerstones of IAI management include rapid, accurate diagnostics; timely, adequate source control; appropriate, short-duration antimicrobial therapy administered according to the principles of pharmacokinetics/pharmacodynamics and antimicrobial stewardship; and hemodynamic and organ functional support with intravenous fluid and adjunctive vasopressor agents for critical illness (sepsis/organ dysfunction or septic shock after correction of hypovolemia). In patients with IAIs, a personalized approach is crucial to optimize outcomes and should be based on multiple aspects that require careful clinical assessment. The anatomic extent of infection, the presumed pathogens involved and risk factors for antimicrobial resistance, the origin and extent of the infection, the patient's clinical condition, and the host's immune status should be assessed continuously to optimize the management of patients with complicated IAIs.
2024
Sartelli, M., Barie, P., Agnoletti, V., Al-Hasan, M.N., Ansaloni, L., Biffl, W., et al. (2024). Intra-abdominal infections survival guide: a position statement by the Global Alliance For Infections In Surgery. WORLD JOURNAL OF EMERGENCY SURGERY, 19(1), 1-20 [10.1186/s13017-024-00552-9].
Sartelli, Massimo; Barie, Philip; Agnoletti, Vanni; Al-Hasan, Majdi N.; Ansaloni, Luca; Biffl, Walter; Buonomo, Luis; Blot, Stijn; Cheadle, William G....espandi
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/995564
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 0
social impact