A 17-year-old girl with type 1 diabetes mellitus (T1DM) and celiac disease (CD) presented with fluctuating aminotransferase levels and hepatomegaly. Poor compliance with a gluten-free diet and poorly controlled T1DM were identified as contributing factors. Investigations revealed elevated liver enzymes and lipid profile, with negative results for infectious causes and autoimmune markers. Liver biopsy confirmed a diagnosis of "Mauriac" hepatic glycogenosis secondary to brittle diabetes. With improved glycemic control, liver function and size normalized. Hepatic glycogenosis, an underrecognized complication of T1DM, is reversible with euglycemic control.
Bua, J., Marchetti, F., Faleschini, E., Ventura, A., Bussani, R. (2010). Hepatic Glycogenosis in an Adolescent with Diabetes. THE JOURNAL OF PEDIATRICS, 157(6), 1042-1042 [10.1016/j.jpeds.2010.06.018].
Hepatic Glycogenosis in an Adolescent with Diabetes
Marchetti, Federico;
2010
Abstract
A 17-year-old girl with type 1 diabetes mellitus (T1DM) and celiac disease (CD) presented with fluctuating aminotransferase levels and hepatomegaly. Poor compliance with a gluten-free diet and poorly controlled T1DM were identified as contributing factors. Investigations revealed elevated liver enzymes and lipid profile, with negative results for infectious causes and autoimmune markers. Liver biopsy confirmed a diagnosis of "Mauriac" hepatic glycogenosis secondary to brittle diabetes. With improved glycemic control, liver function and size normalized. Hepatic glycogenosis, an underrecognized complication of T1DM, is reversible with euglycemic control.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
