SUMMARY - Transcripts for sweet and bitter taste receptors and the gustatory G proteins, alpha-gustducin and alpha-transducin, are expressed by the oral cavity and the gastrointestinal (GI) mucosa. This study evaluated: 1) distribution of alpha-transducin in the pig GI tract; 2) type of cells expressing alpha-transducin (chromogranin-A, gastrin/cholecystokinin, somatostatin, villin) 3) relationship between alpha-transducin cells and enteric fibres. The presence of alpha-transducin-IR in enteroendocrine cells supports an active chemosensory machinery in the GI mucosa and that taste signalling molecules contribute to luminal chemosensing. These mechanisms may occur via neuro-endocrine cross-talk activating digestive or protective reflex pathways (e.g. vomiting or food aversion).

Espressione dell’ α-transducina, una molecola della chemorecezione, in cellule endocrine e non endocrine del tratto gastrointestinale di suino.

CLAVENZANI, PAOLO;DE GIORGIO, ROBERTO;MAZZONI, MAURIZIO;CHIOCCHETTI, ROBERTO;BARBARA, GIOVANNI;LALATTA COSTERBOSA, GIOVANNA;
2008

Abstract

SUMMARY - Transcripts for sweet and bitter taste receptors and the gustatory G proteins, alpha-gustducin and alpha-transducin, are expressed by the oral cavity and the gastrointestinal (GI) mucosa. This study evaluated: 1) distribution of alpha-transducin in the pig GI tract; 2) type of cells expressing alpha-transducin (chromogranin-A, gastrin/cholecystokinin, somatostatin, villin) 3) relationship between alpha-transducin cells and enteric fibres. The presence of alpha-transducin-IR in enteroendocrine cells supports an active chemosensory machinery in the GI mucosa and that taste signalling molecules contribute to luminal chemosensing. These mechanisms may occur via neuro-endocrine cross-talk activating digestive or protective reflex pathways (e.g. vomiting or food aversion).
2008
Atti LXII Conv. Naz. S.I.S.Vet.
5
6
CLAVENZANI P.; DE GIORGIO R.; MAZZONI M.; CHIOCCHETTI R.; BARBARA G.; LALATTA COSTERBOSA G.; RUSSO D.; STERNINI C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/98502
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