SUMMARY - Transcripts for sweet and bitter taste receptors and the gustatory G proteins, alpha-gustducin and alpha-transducin, are expressed by the oral cavity and the gastrointestinal (GI) mucosa. This study evaluated: 1) distribution of alpha-transducin in the pig GI tract; 2) type of cells expressing alpha-transducin (chromogranin-A, gastrin/cholecystokinin, somatostatin, villin) 3) relationship between alpha-transducin cells and enteric fibres. The presence of alpha-transducin-IR in enteroendocrine cells supports an active chemosensory machinery in the GI mucosa and that taste signalling molecules contribute to luminal chemosensing. These mechanisms may occur via neuro-endocrine cross-talk activating digestive or protective reflex pathways (e.g. vomiting or food aversion).
CLAVENZANI P., DE GIORGIO R., MAZZONI M., CHIOCCHETTI R., BARBARA G., LALATTA COSTERBOSA G., et al. (2008). Espressione dell’ α-transducina, una molecola della chemorecezione, in cellule endocrine e non endocrine del tratto gastrointestinale di suino.. MESSINA : Scuderi.
Espressione dell’ α-transducina, una molecola della chemorecezione, in cellule endocrine e non endocrine del tratto gastrointestinale di suino.
CLAVENZANI, PAOLO;DE GIORGIO, ROBERTO;MAZZONI, MAURIZIO;CHIOCCHETTI, ROBERTO;BARBARA, GIOVANNI;LALATTA COSTERBOSA, GIOVANNA;
2008
Abstract
SUMMARY - Transcripts for sweet and bitter taste receptors and the gustatory G proteins, alpha-gustducin and alpha-transducin, are expressed by the oral cavity and the gastrointestinal (GI) mucosa. This study evaluated: 1) distribution of alpha-transducin in the pig GI tract; 2) type of cells expressing alpha-transducin (chromogranin-A, gastrin/cholecystokinin, somatostatin, villin) 3) relationship between alpha-transducin cells and enteric fibres. The presence of alpha-transducin-IR in enteroendocrine cells supports an active chemosensory machinery in the GI mucosa and that taste signalling molecules contribute to luminal chemosensing. These mechanisms may occur via neuro-endocrine cross-talk activating digestive or protective reflex pathways (e.g. vomiting or food aversion).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
