Synthetic cannabinoid receptor agonists were enantioseparated with Whelk-O®1 CSPs. Efficient enantioseparations were obtained under reversed-phase conditions. The developed HPLC method was compatible to MS detection. The ICCA concept was useful to appraise the enantiopurity of the studied compounds. Coupling ECD analysis to in silico simulations allowed to establish the EEO.
Varfaj, I., Protti, M., Di Michele, A., Gonzalez-Rodriguez, J., Carotti, A., Sardella, R., et al. (2024). Chromatographic enantioresolution and stereochemical characterization of synthetic cannabinoid receptor agonists with Whelk-O®1 chiral stationary phases under mass spectrometry compatible reversed-phase conditions: A study case with seized samples. ANALYTICA CHIMICA ACTA, 1317, 1-8 [10.1016/j.aca.2024.342901].
Chromatographic enantioresolution and stereochemical characterization of synthetic cannabinoid receptor agonists with Whelk-O®1 chiral stationary phases under mass spectrometry compatible reversed-phase conditions: A study case with seized samples
Protti M.Co-primo
Membro del Collaboration Group
;Mercolini L.Ultimo
Membro del Collaboration Group
2024
Abstract
Synthetic cannabinoid receptor agonists were enantioseparated with Whelk-O®1 CSPs. Efficient enantioseparations were obtained under reversed-phase conditions. The developed HPLC method was compatible to MS detection. The ICCA concept was useful to appraise the enantiopurity of the studied compounds. Coupling ECD analysis to in silico simulations allowed to establish the EEO.| File | Dimensione | Formato | |
|---|---|---|---|
|
11585_983574 (1).pdf
embargo fino al 13/08/2025
Tipo:
Postprint
Licenza:
Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale - Non opere derivate (CCBYNCND)
Dimensione
651.48 kB
Formato
Adobe PDF
|
651.48 kB | Adobe PDF | Visualizza/Apri Contatta l'autore |
|
11585_983574 - Supporting Information.pdf
embargo fino al 13/08/2025
Tipo:
File Supplementare
Licenza:
Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale - Non opere derivate (CCBYNCND)
Dimensione
640.72 kB
Formato
Adobe PDF
|
640.72 kB | Adobe PDF | Visualizza/Apri Contatta l'autore |
|
11585_983554 - Supplementary Data.pdf
embargo fino al 13/08/2025
Tipo:
File Supplementare
Licenza:
Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale - Non opere derivate (CCBYNCND)
Dimensione
336.5 kB
Formato
Adobe PDF
|
336.5 kB | Adobe PDF | Visualizza/Apri Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
