Impaired mitochondria cause an impressive decrease in ATP production becoming a common condition of cardiovascular diseases. Myxomatous mitral valve disease (MMVD) is characterized by mitochondrial dysfunction. By a non-invasive procedure of metabolism analysis on peripheral blood mononuclear cells, we exploit ex-vivo studies that directly constitute a translational approach to evaluate the cell bioenergetics. Cell ATP production decreased in the presence of MMVD, whereas glycolysis was unaffected. In MMVD, the mitochondrial activity underwent a significant reduction of basal respiration, maximal respiration, and ATP production. Our results depicted a pathological condition of MMVD characterized by cell metabolism deprived of mitochondrial energy support.

Granata S., Bernardini C., Glogowski P.A., Romito G., Salaroli R., Algieri C., et al. (2024). Mitochondrial bioenergetic dysfunction linked to myxomatous mitral valve degeneration explored by PBMCs metabolism analysis. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1865(4), 1-4 [10.1016/j.bbabio.2024.149505].

Mitochondrial bioenergetic dysfunction linked to myxomatous mitral valve degeneration explored by PBMCs metabolism analysis

Granata S.;Bernardini C.;Glogowski P. A.;Romito G.;Salaroli R.;Algieri C.;Cugliari A.;Fabbri M.;Trombetti F.;Zannoni A.;Nesci S.
Ultimo
Supervision
2024

Abstract

Impaired mitochondria cause an impressive decrease in ATP production becoming a common condition of cardiovascular diseases. Myxomatous mitral valve disease (MMVD) is characterized by mitochondrial dysfunction. By a non-invasive procedure of metabolism analysis on peripheral blood mononuclear cells, we exploit ex-vivo studies that directly constitute a translational approach to evaluate the cell bioenergetics. Cell ATP production decreased in the presence of MMVD, whereas glycolysis was unaffected. In MMVD, the mitochondrial activity underwent a significant reduction of basal respiration, maximal respiration, and ATP production. Our results depicted a pathological condition of MMVD characterized by cell metabolism deprived of mitochondrial energy support.
2024
Granata S., Bernardini C., Glogowski P.A., Romito G., Salaroli R., Algieri C., et al. (2024). Mitochondrial bioenergetic dysfunction linked to myxomatous mitral valve degeneration explored by PBMCs metabolism analysis. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1865(4), 1-4 [10.1016/j.bbabio.2024.149505].
Granata S.; Bernardini C.; Glogowski P.A.; Romito G.; Salaroli R.; Algieri C.; Cugliari A.; Fabbri M.; Trombetti F.; Zannoni A.; Nesci S.
File in questo prodotto:
File Dimensione Formato  
postprint_BBA Bioenergetics.pdf

embargo fino al 15/08/2025

Tipo: Postprint
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale - Non opere derivate (CCBYNCND)
Dimensione 1.7 MB
Formato Adobe PDF
1.7 MB Adobe PDF   Visualizza/Apri   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/978934
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact