The use of stabilized cationic intermediates can be considered as a new frontier in the development of stereoselective reactions. An organocatalytic procedure mediated by the MacMillan imidazolidinone catalyst was coupled with an InBr3-mediated process for the development of a novel stereoselective allylation reaction of aldehydes. Up to 98 % ee and up to 5:1 d.r. were obtained in the process.
Merging Organocatalysis with an Indium(III)-Mediated Process: A Stereoselective alpha-Alkylation of Aldehydes with Allylic Alcohols / Montse Guiteras Capdevila; Fides Benfatti; Luca Zoli; Marco Stenta; Pier Giorgio Cozzi. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - STAMPA. - 16:37(2010), pp. 11237-11241. [10.1002/chem.201001693]
Merging Organocatalysis with an Indium(III)-Mediated Process: A Stereoselective alpha-Alkylation of Aldehydes with Allylic Alcohols
COZZI, PIER GIORGIO
2010
Abstract
The use of stabilized cationic intermediates can be considered as a new frontier in the development of stereoselective reactions. An organocatalytic procedure mediated by the MacMillan imidazolidinone catalyst was coupled with an InBr3-mediated process for the development of a novel stereoselective allylation reaction of aldehydes. Up to 98 % ee and up to 5:1 d.r. were obtained in the process.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
