The use of stabilized cationic intermediates can be considered as a new frontier in the development of stereoselective reactions. An organocatalytic procedure mediated by the MacMillan imidazolidinone catalyst was coupled with an InBr3-mediated process for the development of a novel stereoselective allylation reaction of aldehydes. Up to 98 % ee and up to 5:1 d.r. were obtained in the process.

Merging Organocatalysis with an Indium(III)-Mediated Process: A Stereoselective alpha-Alkylation of Aldehydes with Allylic Alcohols

COZZI, PIER GIORGIO
2010

Abstract

The use of stabilized cationic intermediates can be considered as a new frontier in the development of stereoselective reactions. An organocatalytic procedure mediated by the MacMillan imidazolidinone catalyst was coupled with an InBr3-mediated process for the development of a novel stereoselective allylation reaction of aldehydes. Up to 98 % ee and up to 5:1 d.r. were obtained in the process.
Montse Guiteras Capdevila; Fides Benfatti; Luca Zoli; Marco Stenta; Pier Giorgio Cozzi
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/97534
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