: Upfront high-dose therapy with melphalan (HDM) followed by autologous stem cell transplantation (ASCT) has established itself as a core treatment for newly diagnosed multiple my-eloma (NDMM) patients in the past 30 years. Induction therapy, HDM-ASCT, and subsequent con-solidation and maintenance therapy comprise the current fundamental framework for MM treat-ment. The introduction of anti-CD38 monoclonal antibodies such as daratumumab and isatuximab has changed the treatment paradigm for transplant-eligible NDMM patients in that quadruplets have become the new standard induction therapy. The treatment landscape of MM is undergoing a transformative shift with the introduction of potent new immunotherapies, such as chimeric antigen receptor (CAR)-T cells and bispecific antibodies (BsAbs), which are currently used in the re-lapsed/refractory setting (RRMM) and are already being tested in the NDMM. This review will focus on the incorporation of immunotherapy in the treatment scenario of NDMM patients eligible for ASCT.

Multiple Myeloma: The Role of Autologous Stem Cell Transplantation in the Era of Immunotherapy / Rocchi, Serena; Zannetti, Beatrice Anna; Marconi, Giovanni; Lanza, Francesco. - In: CELLS. - ISSN 2073-4409. - ELETTRONICO. - 13:10(2024), pp. 853-853. [10.3390/cells13100853]

Multiple Myeloma: The Role of Autologous Stem Cell Transplantation in the Era of Immunotherapy

Rocchi, Serena;Zannetti, Beatrice Anna;Marconi, Giovanni;Lanza, Francesco
Ultimo
Writing – Original Draft Preparation
2024

Abstract

: Upfront high-dose therapy with melphalan (HDM) followed by autologous stem cell transplantation (ASCT) has established itself as a core treatment for newly diagnosed multiple my-eloma (NDMM) patients in the past 30 years. Induction therapy, HDM-ASCT, and subsequent con-solidation and maintenance therapy comprise the current fundamental framework for MM treat-ment. The introduction of anti-CD38 monoclonal antibodies such as daratumumab and isatuximab has changed the treatment paradigm for transplant-eligible NDMM patients in that quadruplets have become the new standard induction therapy. The treatment landscape of MM is undergoing a transformative shift with the introduction of potent new immunotherapies, such as chimeric antigen receptor (CAR)-T cells and bispecific antibodies (BsAbs), which are currently used in the re-lapsed/refractory setting (RRMM) and are already being tested in the NDMM. This review will focus on the incorporation of immunotherapy in the treatment scenario of NDMM patients eligible for ASCT.
2024
Multiple Myeloma: The Role of Autologous Stem Cell Transplantation in the Era of Immunotherapy / Rocchi, Serena; Zannetti, Beatrice Anna; Marconi, Giovanni; Lanza, Francesco. - In: CELLS. - ISSN 2073-4409. - ELETTRONICO. - 13:10(2024), pp. 853-853. [10.3390/cells13100853]
Rocchi, Serena; Zannetti, Beatrice Anna; Marconi, Giovanni; Lanza, Francesco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/969967
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