Ca2+ is a key molecule controlling several cellular processes, from fertilization to cell death, in all cell types. In excitable and contracting cells, such as cardiac myocytes, Ca2+ controls muscle contractility. The spatial and temporal segregation of Ca2+ concentrations are central to maintain its concentration gradients across the cells and the cellular compartments for proper function. SERCA2a is a cornerstone molecule for maintaining a balanced concentration of Ca2+ during the cardiac cycle, since it controls the transport of Ca2+ to the sarcoplasmic reticulum (SR) during relaxation. Alterations of the activity of this pump have been widely investigated, emphasizing its central role in the control of Ca2+ homeostasis and consequently in the pathogenesis of the contractile defect seen with heart failure. This review focuses on the molecular characteristics of the pump, its role during the cardiac cycle and the prospects derived from the manipulation of SERCA2a for heart failure treatment.
Gianni D Chan J, Gwathmey JK, del Monte F, Hajjar RJ (2005). SERCA2a in heart failure: role and therapeutic prospects. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 37(6), 375-380 [10.1007/s10863-005-9474-z].
SERCA2a in heart failure: role and therapeutic prospects
del Monte F;
2005
Abstract
Ca2+ is a key molecule controlling several cellular processes, from fertilization to cell death, in all cell types. In excitable and contracting cells, such as cardiac myocytes, Ca2+ controls muscle contractility. The spatial and temporal segregation of Ca2+ concentrations are central to maintain its concentration gradients across the cells and the cellular compartments for proper function. SERCA2a is a cornerstone molecule for maintaining a balanced concentration of Ca2+ during the cardiac cycle, since it controls the transport of Ca2+ to the sarcoplasmic reticulum (SR) during relaxation. Alterations of the activity of this pump have been widely investigated, emphasizing its central role in the control of Ca2+ homeostasis and consequently in the pathogenesis of the contractile defect seen with heart failure. This review focuses on the molecular characteristics of the pump, its role during the cardiac cycle and the prospects derived from the manipulation of SERCA2a for heart failure treatment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
