The pure enantiomers of 2,5-dimethylbicyclo[3.2.0]heptan-endo-2-ol, key intermediate in the synthesis of grandisol, have been conveniently prepared by optical resolution with (2S)-(-)-and (2R)-(+)-1-(4-toluenesulphonyl)pyrrolidine-2carboxylic acid chloride (NTP-Cl) as resolving agents, and by an EPC synthesis employing commercially available (3R)-(-)-and (3S)-(+)-linalool as chiral sources.
Resolution and EPC synthesis of both enantiomers of 2,5-Dimethylbicyclo[3.2.0]heptan-endo-2-ol, Key Intermediate in the Synthesis of Grandisol / Rosini, Goffredo; Marotta, Emanuela; Raimondi, Andrea; Righi, Paolo. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - STAMPA. - 2:2(1991), pp. 123-138. [10.1016/s0957-4166(00)80532-7]
Resolution and EPC synthesis of both enantiomers of 2,5-Dimethylbicyclo[3.2.0]heptan-endo-2-ol, Key Intermediate in the Synthesis of Grandisol
Rosini, Goffredo;Marotta, Emanuela;Righi, Paolo
1991
Abstract
The pure enantiomers of 2,5-dimethylbicyclo[3.2.0]heptan-endo-2-ol, key intermediate in the synthesis of grandisol, have been conveniently prepared by optical resolution with (2S)-(-)-and (2R)-(+)-1-(4-toluenesulphonyl)pyrrolidine-2carboxylic acid chloride (NTP-Cl) as resolving agents, and by an EPC synthesis employing commercially available (3R)-(-)-and (3S)-(+)-linalool as chiral sources.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
