The synthesis of spiro compounds via a Michael–Michael-aldol reaction is reported. The reaction affords spirooxindole derivatives in good yields and in almost diastereo- and enantiopure form. Moreover, the reaction works with several heterocycles such as oxindoles, benzofuranones, pyrazolones or azlactones rendering the final spiro compounds in good yields and excellent stereoselectivities
X. Companyo, A. Zea, A.N.R. Alba, A. Mazzanti, A. Moyanoa, R. Rios (2010). Organocatalytic synthesis of spiro compounds via a cascade Michael–Michael-aldol reaction. CHEMICAL COMMUNICATIONS, 46, 6953-6955 [10.1039/c0cc01522a].
Organocatalytic synthesis of spiro compounds via a cascade Michael–Michael-aldol reaction
MAZZANTI, ANDREA;
2010
Abstract
The synthesis of spiro compounds via a Michael–Michael-aldol reaction is reported. The reaction affords spirooxindole derivatives in good yields and in almost diastereo- and enantiopure form. Moreover, the reaction works with several heterocycles such as oxindoles, benzofuranones, pyrazolones or azlactones rendering the final spiro compounds in good yields and excellent stereoselectivitiesFile in questo prodotto:
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