Regenerative medicine aims to identify new research strategies for the repair and restoration of tissues damaged by pathological or accidental events. Mesenchymal stem cells (MSCs) play a key role in regenerative medicine approaches due to their specific properties, such as the high rate of proliferation, the ability to differentiate into several cell lineages, the immunomodulatory potential, and their easy isolation with minimal ethical issues. One of the main goals of regenerative medicine is to modulate, both in vitro and in vivo, the differentiation potential of MSCs to improve their use in the repair of damaged tissues. Over the years, much evidence has been collected about the ability of cytochalasins, a large family of 60 metabolites isolated mainly from fungi, to modulate multiple properties of stem cells (SCs), such as proliferation, migration, and differentiation, by altering the organization of the cyto- and the nucleo-skeleton. In this review, we discussed the ability of two different cytochalasins, cytochalasins D and B, to influence specific SC differentiation programs modulated by several agents (chemical or physical) or intra- and extra-cellular factors, with particular attention to human MSCs (hMSCs).

Cytochalasins as Modulators of Stem Cell Differentiation / Pampanella, Luca; Petrocelli, Giovannamaria; Abruzzo, Provvidenza Maria; Zucchini, Cinzia; Canaider, Silvia; Ventura, Carlo; Facchin, Federica. - In: CELLS. - ISSN 2073-4409. - ELETTRONICO. - 13:5:400(2024), pp. 1-23. [10.3390/cells13050400]

Cytochalasins as Modulators of Stem Cell Differentiation

Pampanella, Luca;Petrocelli, Giovannamaria;Abruzzo, Provvidenza Maria;Zucchini, Cinzia;Canaider, Silvia
;
Ventura, Carlo
;
Facchin, Federica
2024

Abstract

Regenerative medicine aims to identify new research strategies for the repair and restoration of tissues damaged by pathological or accidental events. Mesenchymal stem cells (MSCs) play a key role in regenerative medicine approaches due to their specific properties, such as the high rate of proliferation, the ability to differentiate into several cell lineages, the immunomodulatory potential, and their easy isolation with minimal ethical issues. One of the main goals of regenerative medicine is to modulate, both in vitro and in vivo, the differentiation potential of MSCs to improve their use in the repair of damaged tissues. Over the years, much evidence has been collected about the ability of cytochalasins, a large family of 60 metabolites isolated mainly from fungi, to modulate multiple properties of stem cells (SCs), such as proliferation, migration, and differentiation, by altering the organization of the cyto- and the nucleo-skeleton. In this review, we discussed the ability of two different cytochalasins, cytochalasins D and B, to influence specific SC differentiation programs modulated by several agents (chemical or physical) or intra- and extra-cellular factors, with particular attention to human MSCs (hMSCs).
2024
Cytochalasins as Modulators of Stem Cell Differentiation / Pampanella, Luca; Petrocelli, Giovannamaria; Abruzzo, Provvidenza Maria; Zucchini, Cinzia; Canaider, Silvia; Ventura, Carlo; Facchin, Federica. - In: CELLS. - ISSN 2073-4409. - ELETTRONICO. - 13:5:400(2024), pp. 1-23. [10.3390/cells13050400]
Pampanella, Luca; Petrocelli, Giovannamaria; Abruzzo, Provvidenza Maria; Zucchini, Cinzia; Canaider, Silvia; Ventura, Carlo; Facchin, Federica
File in questo prodotto:
File Dimensione Formato  
cells-13-00400-1.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY)
Dimensione 1.7 MB
Formato Adobe PDF
1.7 MB Adobe PDF Visualizza/Apri
cells-2860637-supplementary.pdf

accesso aperto

Descrizione: Supplementary Materials
Tipo: File Supplementare
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY)
Dimensione 145.15 kB
Formato Adobe PDF
145.15 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/966514
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact