(1) Background: BRAF mutations affect 4–5% of lung adenocarcinomas. This study aimed to analyze the clinicopathological features of lung carcinomas with BRAF mutations, focusing on V600E vs. non-V600E and the presence of co-mutations. (2) Methods: All BRAF-mutated lung carcinomas were retrieved from a molecular diagnostic unit (the reference unit for four different hospitals). The samples were analyzed using next-generation sequencing. Statistical analyses included log-rank tests for overall survival (OS) and progression-free survival (PFS). (3) Results: In total, 60 BRAF-mutated lung carcinomas were retrieved: 24 (40.0%) with V600E and 36 (60.0%) with non-V600E mutations, and 21 (35.0%) with other co-mutations and 39 (65.0%) with only BRAF mutations. Survival data were available for 54/60 (90.0%) cases. Targeted therapy was documented in 11 cases. Patients with V600E mutations exhibited a better prognosis than patients with non-V600E mutations (p = 0.008 for OS, p = 0.018 for PFS); this was confirmed in PFS (p = 0.036) when considering only patients who received no targeted therapy. Patients with co-mutations displayed no prognostic difference compared to patients carrying only BRAF mutations (p = 0.590 for OS, p = 0.938 for PFS). (4) Conclusions: BRAF-mutated lung carcinomas with V600E (40.0%) had a better prognosis than those without V600E. Concomitant co-mutations (35.0%) did not affect the prognosis.

Clinicopathological Features of Non-Small Cell Lung Carcinoma with BRAF Mutation / Ambrosini-Spaltro A.; Rengucci C.; Capelli L.; Chiadini E.; Calistri D.; Bennati C.; Cravero P.; Limarzi F.; Nosseir S.; Panzacchi R.; Valli M.; Ulivi P.; Rossi G.. - In: CURRENT ONCOLOGY. - ISSN 1718-7729. - ELETTRONICO. - 30:11(2023), pp. 10019-10032. [10.3390/curroncol30110728]

Clinicopathological Features of Non-Small Cell Lung Carcinoma with BRAF Mutation

Chiadini E.;Cravero P.;Limarzi F.;Panzacchi R.;Ulivi P.;
2023

Abstract

(1) Background: BRAF mutations affect 4–5% of lung adenocarcinomas. This study aimed to analyze the clinicopathological features of lung carcinomas with BRAF mutations, focusing on V600E vs. non-V600E and the presence of co-mutations. (2) Methods: All BRAF-mutated lung carcinomas were retrieved from a molecular diagnostic unit (the reference unit for four different hospitals). The samples were analyzed using next-generation sequencing. Statistical analyses included log-rank tests for overall survival (OS) and progression-free survival (PFS). (3) Results: In total, 60 BRAF-mutated lung carcinomas were retrieved: 24 (40.0%) with V600E and 36 (60.0%) with non-V600E mutations, and 21 (35.0%) with other co-mutations and 39 (65.0%) with only BRAF mutations. Survival data were available for 54/60 (90.0%) cases. Targeted therapy was documented in 11 cases. Patients with V600E mutations exhibited a better prognosis than patients with non-V600E mutations (p = 0.008 for OS, p = 0.018 for PFS); this was confirmed in PFS (p = 0.036) when considering only patients who received no targeted therapy. Patients with co-mutations displayed no prognostic difference compared to patients carrying only BRAF mutations (p = 0.590 for OS, p = 0.938 for PFS). (4) Conclusions: BRAF-mutated lung carcinomas with V600E (40.0%) had a better prognosis than those without V600E. Concomitant co-mutations (35.0%) did not affect the prognosis.
2023
Clinicopathological Features of Non-Small Cell Lung Carcinoma with BRAF Mutation / Ambrosini-Spaltro A.; Rengucci C.; Capelli L.; Chiadini E.; Calistri D.; Bennati C.; Cravero P.; Limarzi F.; Nosseir S.; Panzacchi R.; Valli M.; Ulivi P.; Rossi G.. - In: CURRENT ONCOLOGY. - ISSN 1718-7729. - ELETTRONICO. - 30:11(2023), pp. 10019-10032. [10.3390/curroncol30110728]
Ambrosini-Spaltro A.; Rengucci C.; Capelli L.; Chiadini E.; Calistri D.; Bennati C.; Cravero P.; Limarzi F.; Nosseir S.; Panzacchi R.; Valli M.; Ulivi P.; Rossi G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/965325
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