Pathological activation of the immune-competent glial cells is an obligatory event in neurodegenerative diseases. The secondary recruitment of astrocytes, resulting from an upgraded microglial activation, represents a critical point. Reactive astrocytes have to give up physiologically important functions (control of extracellular homeostasis and of synaptic transmission) and build a synergistic alliance with microglia in promoting oxidative, excitotoxic and β-amyloid-induced neuronal damage. Growing understanding of the pathogenically relevant molecular signaling pathways opens new possibilities of pharmacological corrections at the second messenger level. Here, the respective know-how of endogenous modulators, such as adenosine, might be used. The aim should be a titration of the glia reaction in order to maintain supposed beneficial functions of reactive microglia and to prevent the dangerous involvement of astrocytes.

Pathological glial reactions in neurodegenerative disorders: Prospects for future therapeutics / Schubert P.; Ferroni S.. - In: EXPERT REVIEW OF NEUROTHERAPEUTICS. - ISSN 1473-7175. - STAMPA. - 3:3(2003), pp. 279-287. [10.1586/14737175.3.3.279]

Pathological glial reactions in neurodegenerative disorders: Prospects for future therapeutics

Ferroni S.
2003

Abstract

Pathological activation of the immune-competent glial cells is an obligatory event in neurodegenerative diseases. The secondary recruitment of astrocytes, resulting from an upgraded microglial activation, represents a critical point. Reactive astrocytes have to give up physiologically important functions (control of extracellular homeostasis and of synaptic transmission) and build a synergistic alliance with microglia in promoting oxidative, excitotoxic and β-amyloid-induced neuronal damage. Growing understanding of the pathogenically relevant molecular signaling pathways opens new possibilities of pharmacological corrections at the second messenger level. Here, the respective know-how of endogenous modulators, such as adenosine, might be used. The aim should be a titration of the glia reaction in order to maintain supposed beneficial functions of reactive microglia and to prevent the dangerous involvement of astrocytes.
2003
Pathological glial reactions in neurodegenerative disorders: Prospects for future therapeutics / Schubert P.; Ferroni S.. - In: EXPERT REVIEW OF NEUROTHERAPEUTICS. - ISSN 1473-7175. - STAMPA. - 3:3(2003), pp. 279-287. [10.1586/14737175.3.3.279]
Schubert P.; Ferroni S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/964263
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