Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94–1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88–0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85–0.99) and 0.78 (95% CI = 0.73–0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91–1.02) for cardia, 1.03 (95% CI = 1.00–1.07) for non-cardia, 1.12 (95% CI = 1.07–1.19) for diffuse and 1.02 (95% CI = 0.97–1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.

Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium / Collatuzzo G.; Negri E.; Pelucchi C.; Bonzi R.; Turati F.; Rabkin C.S.; Liao L.M.; Sinha R.; Palli D.; Ferraroni M.; Lopez-Carrillo L.; Lunet N.; Morais S.; Albanes D.; Weinstein S.J.; Parisi D.; Zaridze D.; Maximovitch D.; Dierssen-Sotos T.; Jimenez-Moleon J.J.; Vioque J.; Garcia de la Hera M.; Curado M.P.; Dias-Neto E.; Hernandez-Ramirez R.U.; Lopez-Cervantes M.; Ward M.H.; Tsugane S.; Hidaka A.; Lagiou A.; Lagiou P.; Zhang Z.-F.; Trichopoulou A.; Karakatsani A.; Camargo M.C.; La Vecchia C.; Boffetta P.. - In: NUTRIENTS. - ISSN 2072-6643. - ELETTRONICO. - 15:8(2023), pp. 1877.1-1877.13. [10.3390/nu15081877]

Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium

Collatuzzo G.;Negri E.;Boffetta P.
2023

Abstract

Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94–1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88–0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85–0.99) and 0.78 (95% CI = 0.73–0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91–1.02) for cardia, 1.03 (95% CI = 1.00–1.07) for non-cardia, 1.12 (95% CI = 1.07–1.19) for diffuse and 1.02 (95% CI = 0.97–1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.
2023
Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium / Collatuzzo G.; Negri E.; Pelucchi C.; Bonzi R.; Turati F.; Rabkin C.S.; Liao L.M.; Sinha R.; Palli D.; Ferraroni M.; Lopez-Carrillo L.; Lunet N.; Morais S.; Albanes D.; Weinstein S.J.; Parisi D.; Zaridze D.; Maximovitch D.; Dierssen-Sotos T.; Jimenez-Moleon J.J.; Vioque J.; Garcia de la Hera M.; Curado M.P.; Dias-Neto E.; Hernandez-Ramirez R.U.; Lopez-Cervantes M.; Ward M.H.; Tsugane S.; Hidaka A.; Lagiou A.; Lagiou P.; Zhang Z.-F.; Trichopoulou A.; Karakatsani A.; Camargo M.C.; La Vecchia C.; Boffetta P.. - In: NUTRIENTS. - ISSN 2072-6643. - ELETTRONICO. - 15:8(2023), pp. 1877.1-1877.13. [10.3390/nu15081877]
Collatuzzo G.; Negri E.; Pelucchi C.; Bonzi R.; Turati F.; Rabkin C.S.; Liao L.M.; Sinha R.; Palli D.; Ferraroni M.; Lopez-Carrillo L.; Lunet N.; Morais S.; Albanes D.; Weinstein S.J.; Parisi D.; Zaridze D.; Maximovitch D.; Dierssen-Sotos T.; Jimenez-Moleon J.J.; Vioque J.; Garcia de la Hera M.; Curado M.P.; Dias-Neto E.; Hernandez-Ramirez R.U.; Lopez-Cervantes M.; Ward M.H.; Tsugane S.; Hidaka A.; Lagiou A.; Lagiou P.; Zhang Z.-F.; Trichopoulou A.; Karakatsani A.; Camargo M.C.; La Vecchia C.; Boffetta P.
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