Background: Venous thromboembolism (VTE), encompassing both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a leading cause of morbidity and mortality worldwide.Methods: GARFIELD-VTE is a prospective, non-interventional observational study of real-world treatment practices. We aimed to capture the 36-month clinical outcomes of 10,679 patients with objectively confirmed VTE enrolled between May 2014 and January 2017 from 415 sites in 28 countries.Findings: A total of 6582 (61.6 %) patients had DVT alone, 4097 (38.4 %) had PE +/- DVT. At baseline, 98.1 % of patients received anticoagulation (AC) with or without other modalities of therapy. The proportion of patients on AC therapy decreased over time: 87.6 % at 3 months, 73.0 % at 6 months, 54.2 % at 12 months and 42.0 % at 36 months. At 12-months follow-up, the incidences (95 % confidence interval [CI]) of all-cause mortality, recurrent VTE and major bleeding were 6.5 (7.0-8.1), 5.4 (4.9-5.9) and 2.7 (2.4-3.0) per 100 person-years, respectively. At 36-months, these decreased to 4.4 (4.2-4.7), 3.5 (3.2-2.7) and 1.4 (1.3-1.6) per 100 person-years, respectively. Over 36-months, the rate of all-cause mortality and major bleeds were highest in patients treated with parenteral therapy (PAR) versus oral anti-coagulants (OAC) and no OAC, and the rate of recurrent VTE was highest in patients on no OAC versus those on PAR and OAC. The most frequent cause of death after 36-month follow-up was cancer (n = 565, 48.6 %), followed by cardiac (n = 94, 8.1 %), and VTE (n = 38, 3.2 %). Most recurrent VTE events were DVT alone (n = 564, 63.3 %), with the remainder PE, (n = 236, 27.3 %), or PE in combination with DVT (n = 63, 7.3 %).Interpretation: GARFIELD-VTE provides a global perspective of anticoagulation patterns and highlights the accumulation of events within the first 12 months after diagnosis. These findings may help identify treatment gaps for subsequent interventions to improve patient outcomes in this patient population.

36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE / Turpie, Alexander G.G.; Farjat, Alfredo E.; Haas, Sylvia; Ageno, Walter; Weitz, Jeffrey I.; Goldhaber, Samuel Z.; Goto, Shinya; Angchaisuksiri, Pantep; Kayani, Gloria; Lopes, Renato D.; Chiang, Chern-En; Gibbs, Harry; Tse, Eric; Verhamme, Peter; ten Cate, Hugo; Muntaner, Juan; Schellong, Sebastian; Bounameaux, Henri; Prandoni, Paolo; Maheshwari, Uma; Kakkar, Ajay K.; Loualidi, Ab; Colak, Abdurrahim; Bezuidenhout, Abraham; Abdool-Carrim, Abu; Azeddine, Addala; Beyers, Adriaan; Dees, Adriaan; Mohamed, Ahmed; Aksoy, Ahmet; Abiko, Akihiko; Watanabe, Akinori; Krichell, Alan; Fernandez, Alberto Alfredo; Tosetto, Alberto; Khotuntsov, Alexey; Oropallo, Alisha; Slocombe, Alison; Kelly, Allan; Clark, Amanda; Gad, Amr; Arouni, Amy; Schmidt, Andor; Berni, Andrea; Kleiban, Andres Javier; Machowski, Andrew; Kazakov, Andrey; Galvez, Angel; Lockman, Ann; Falanga, Anna; Chauhan, Anoop; Riera-Mestre, Antoni; Mazzone, Antonino; D'Angelo, Armando; Herdy, Artur; Kato, Atsushi; Salem, Ayman Abd Elhamid Ebrahim Mahmoud; Husin, Azlan; Erdelyi, Barbara; Jacobson, Barry; Amann-Vesti, Beatrice; Battaloglu, Bektas; Wilson, Benedicte; Cosmi, Benilde; Francois, Bergmann Jean; Toufek, Berremeli; Hunt, Beverley; Natha, Bhavesh; Mustafa, Bisher; Kho, Bonnie Chi Shan; Carine, Boulon; Zidel, Brian; Dominique, Brisot; Christophe, Brousse; Trimarco, Bruno; Luo, Canhua; Cuneo, Carlos Alberto; Diaz, Carlos Jerjes Sanchez; Schwencke, Carsten; Cader, Cas; Yavuz, Celal; Zaidman, Cesar Javier; Lunn, Charles; Wu, Chau-Chung; Toh, Cheng Hock; Chiang, Chern-En; Elisa, Chevrier; Hsia, Chien-Hsun; Huang, Chien-Lung; Kwok, Chi-Hang Kevin; Wu, Chih-Cheng; Huang, Chi-Hung; Ward, Chris; Opitz, Christian; Jeanneret-Gris, Christina; Ha, Chung Yin; Huang, Chun-Yao; Bidi, Claude Luyeye; Smith, Clifford; Brauer, Cornelia; Lodigiani, Corrado; Francis, Couturaud; Wu, Cynthia; Staub, Daniel; Theodoro, Daniel; Poli, Daniela; Acevedo, David - Riesco; Adler, David; Jimenez, David; Keeling, David; Scott, David; Imberti, Davide; Creagh, Desmond; Helene, Desmurs-Clavel; Hagemann, Dirk; Le Roux, Dirk; Skowasch, Dirk; Belenky, Dmitry; Dorokhov, Dmitry; Petrov, Dmitry; Zateyshchikov, Dmitry; Prisco, Domenico; Møller, Dorthe; Kucera, Dusan; Esheiba, Ehab M.; Panchenko, Elizaveta; Dominique, Elkouri; Dogan, Emre; Kubat, Emre; Diaz, Enrique Diaz; Tse, Eric Wai Choi; Yeo, Erik; Hashas, Erman; Grochenig, Ernst; Tiraferri, Eros; Blessing, Erwin; Michèle, Escande Orthlieb; Usandizaga, Esther; Porreca, Ettore; Ferroni, Fabian; Nicolas, Falvo; Ayala-Paredes, Félix; Koura, Firas; Henry, Fitjerald; Cosmi, Franco; Erdkamp, Frans; Kamalov, Gadel; Dalmau, Garcia-Bragado; Damien, Garrigues; Klein, Garry; Shah, Gaurand; Hollanders, Geert; Merli, Geno; Plassmann, Georg; Platt, George; Poirier, Germain; Sokurenko, German; Haddad, Ghassan; Ali, Gholam; Agnelli, Giancarlo; Gan, Gin Gin; Kaye-Eddie, Grace; Le Gal, Gregoire; Allen, Gregory; Esperón, Guillermo Antonio Llamas; Jean-Paul, Guillot; Gerofke, Hagen; Elali, Hallah; Burianova, Hana; Ohler, Hans-Juergen; Wang, Haofu; Darius, Harald; Gogia, Harinder S.; Striekwold, Harry; Gibbs, Harry; Hasanoglu, Hatice; Turker, Hatice; Franow, Hendrik; Bounameaux, Henri; De Raedt, Herbert; Schroe, Herman; ElDin, Hesham Salah; Zidan, Hesham; Nakamura, Hiroaki; Kim, Ho Young; Lawall, Holger; Zhu, Hong; Tian, Hongyan; Yhim, Ho-Young; ten Cate, Hugo; Hwang, Hun Gyu; Shim, Hyeok; Kim, Igor; Libov, Igor; Sonkin, Igor; Suchkov, Igor; Song, Ik-Chan; Kiris, Ilker; Staroverov, Ilya; Looi, Irene; De La Azuela Tenorio, Isabel M.; Savas, Ismail; Gordeev, Ivan; Podpera, Ivo; Lee, Jae Hoon; Sathar, Jameela; Welker, James; Beyer-Westendorf, Jan; Kvasnicka, Jan; Vanwelden, Jan; Kim, JangYong; Svobodova, Jaromira; Gujral, Jaspal; Marino, Javier; Galvar, Javier Tristan; Kassis, Jeannine; Kuo, Jen-Yuan; Shih, Jhih-Yuan; Kwon, JiHyun; Joh, Jin Hyun; Park, Jin Hyun; Kim, Jin Seok; Yang, Jinghua; Krupicka, Jiri; Lastuvka, Jiri; Pumprla, Jiri; Vesely, Jiri; Souto, Joan Carlos; Correa, João Antônio; Duchateau, Johan; Fletcher, John Perry; del Toro, Jorge; del Toro, Jorge; Paez, Jorge Guillermo Chavez; Nielsen, Jørn; Filho, Jose Dalmo Araujo; Saraiva, Jose; Peromingo, Jose Antonio Diaz; Lara, Jose Gomez; Fedele, Jose Luis; Surinach, Jose Maria; Chacko, Joseph; Muntaner, Juan Antonio; Benitez, Juan Carlos Álvarez; Abril, Juan Moreno Hoyos; Humphrey, Julian; Bono, Julio; Kanda, Junji; Boondumrongsagoon, Juree; Yiu, Kai Hang; Chansung, Kanchana; Boomars, Karin; Burbury, Kate; Kondo, Katsuhiro; Karaarslan, Kemal; Takeuchi, Kensuke; Kroeger, Knut; Zrazhevskiy, Konstantin; Svatopluk, Koscál; Shyu, Kou-Gi; Vandenbosch, Kristel; Chang, Kuan-Cheng; Chiu, Kuan-Ming; Jean-Manuel, Kubina; Wern, Kwan Jing; Ueng, Kwo-Chang; Norasetthada, Lalita; Binet, Laure; Chew, Lee Ping; Zhang, Lei; Cristina, Leone Maria; Tick, Lidwine; Schiavi, Lilia Beatriz; Wong, Lily Lee Lee; Borges, Lohana; Botha, Louis; Capiau, Luc; Timmermans, Luc; López, Luciano Eduardo; Ria, Luigi; Blasco, Luis Manuel Hernandez; Guzman, Luis Alberto; Cervera, Luis Flota; Isabelle, Mahe; Bosch, Manuel Monreal; de los Rios Ibarra, Manuel; Fernandez, Manuel Núñez; Carrier, Marc; Barrionuevo, Marcelo Raul; Gamba, Marco Antonio Alcocer; Cattaneo, Marco; Moia, Marco; Bowers, Margaret; Chetanachan, Mariam; Berli, Mario Alberto; Fixley, Mark; Faghih, Markus; Stuecker, Markus; Schul, Marlin; Banyai, Martin; Koretzky, Martin; Myriam, Martin; Gaffney, Mary Elizabeth; Hirano, Masao; Kanemoto, Masashi; Nakamura, Mashio; Tahar, Mersel; Emmanuel, Messas; Kovacs, Michael; Leahy, Michael; Levy, Michael; Munch, Michael; Olsen, Michael; De Pauw, Michel; Gustin, Michel; Van Betsbrugge, Michiel; Boyarkin, Mikhail; Homza, Miroslav; Koto, Modise; Abdool-Gaffar, Mohamed; Nagib, Mohamed Ayman Fakhry; El-Dessoki, Mohamed; Khan, Mohamed; Mohamed, Monniaty; Kim, Moo Hyun; Lee, Moon-Hee; Soliman, Mosaad; Ahmed, Mostafa Shawky; el Bary, Mostafa Soliman Abd; Moustafa, Moustafa A.; Hameed, Muhammad; Kanko, Muhip; Majumder, Mujibur; Zubareva, Nadezhda; Mumoli, Nicola; Abdullah, Nik Azim Nik; Makruasi, Nisa; Paruk, Nishen; Kanitsap, Nonglak; Duda, Norberto; Nordin, Nordiana; Nyvad, Ole; Barbarash, Olga; Gurbuz, Orcun; Vilamajo, Oscar Gomez; Flores, Oscar Nandayapa; Gur, Ozcan; Oto, Oztekin; Marchena, Pablo Javier; Angchaisuksiri, Pantep; Carroll, Patrick; Lang, Pavel; MacCallum, Peter; von Bilderling, Peter Baron; Blombery, Peter; Verhamme, Peter; Jansky, Petr; Bernadette, Peuch; De Vleeschauwer, Philippe; Hainaut, Philippe; Ferrini, Piera Maria; Iamsai, Piriyaporn; Christian, Ponchaux; Viboonjuntra, Pongtep; Rojnuckarin, Ponlapat; Ho, Prahlad; Mutirangura, Pramook; Wells, Rachel; Martinez, Rafael; Miranda, Raimundo Tirado; Kroening, Ralf; Ratsela, Rapule; Reyes, Raquel Lopez; de Leon, Raul Franco Diaz; Wong, Raymond Siu Ming; Alikhan, Raz; Jerwan-Keim, Reinhold; Otero, Remedios; Murena-Schmidt, Renate; Canevascini, Reto; Ferkl, Richard; White, Richard; Van Herreweghe, Rika; Santoro, Rita; Klamroth, Robert; Mendes, Robert; Prosecky, Robert; Cappelli, Roberto; Spacek, Rudolf; Singh, Rupesh; Griffin, Sam; Na, Sang Hoon; Chunilal, Sanjeev; Middeldorp, Saskia; Nakazawa, Satoshi; Schellong, Sebastian; Toh, See Guan; Christophe, Seinturier; Isbir, Selim; Raymundo, Selma; Ting, Seng Kiat; Motte, Serge; Aktogu, Serir Ozkan; Donders, Servaas; Cha, Seung Ick; Nam, Seung-Hyun; Marie-Antoinette, Sevestre-Pietri; Maasdorp, Shaun; Sun, Shenghua; Wang, Shenming; Essameldin, Sherif Mohamed; Sholkamy, Sherif Mohamed; Kuki, Shintaro; Goto, Shinya; Yoshida, Shuichi; Matsuoka, Shunzo; McRae, Simon; Watt, Simon; Patanasing, Siriwimon; Jean-Léopold, Siwe-Nana; Wongkhantee, Somchai; Bang, Soo-Mee; Testa, Sophie; Zemek, Stanislav; Behrens, Steffen; Dominique, Stephan; Mellor, Stuart; Singh, Suaran Singh Gurcharan; Datta, Sudip; Chayangsu, Sunee; Solymoss, Susan; Everington, Tamara; Abdel-Azim, Tarek Ahmed Adel; Suwanban, Tawatchai; Adademir, Taylan; Hart, Terence; Béatrice, Terriat; Luvhengo, Thifhelimbilu; Horacek, Thomas; Zeller, Thomas; Boussy, Tim; Reynolds, Tim; Biss, Tina; Chao, Ting-Hsing; Casabella, Tomas Smith; Onodera, Tomoya; Numbenjapon, Tontanai; Gerdes, Victor; Cech, Vladimir; Krasavin, Vladimir; Tolstikhin, Vladimir; Bax, W.A.; Malek, Wagih Fawzy Abdel; Ho, Wai Khoon; Ageno, Walter; Pharr, Walter; Jiang, Weihong; Lin, Wei-Hsiang; Zhang, Weihua; Tseng, Wei-Kung; Lai, Wen-Ter; De Backer, Wilfried; Haverkamp, Wilhelm; Yoshida, Winston; Korte, Wolfgang; Choi, Won Il; Kim, Yang-Ki; Tanabe, Yasuhiro; Ohnuma, Yasushi; Mun, Yeung-Chul; Balthazar, Yohan; Park, Yong; Shibata, Yoshisato; Burov, Yuriy; Subbotin, Yuriy; Coufal, Zdenek; Yang, Zhenwen; Jing, Zhicheng; Jing, Zhicheng; Yang, Zhongqi. - In: THROMBOSIS RESEARCH. - ISSN 0049-3848. - STAMPA. - 222:(2023), pp. 31-39. [10.1016/j.thromres.2022.11.016]

36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE

Cosmi, Benilde;
2023

Abstract

Background: Venous thromboembolism (VTE), encompassing both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a leading cause of morbidity and mortality worldwide.Methods: GARFIELD-VTE is a prospective, non-interventional observational study of real-world treatment practices. We aimed to capture the 36-month clinical outcomes of 10,679 patients with objectively confirmed VTE enrolled between May 2014 and January 2017 from 415 sites in 28 countries.Findings: A total of 6582 (61.6 %) patients had DVT alone, 4097 (38.4 %) had PE +/- DVT. At baseline, 98.1 % of patients received anticoagulation (AC) with or without other modalities of therapy. The proportion of patients on AC therapy decreased over time: 87.6 % at 3 months, 73.0 % at 6 months, 54.2 % at 12 months and 42.0 % at 36 months. At 12-months follow-up, the incidences (95 % confidence interval [CI]) of all-cause mortality, recurrent VTE and major bleeding were 6.5 (7.0-8.1), 5.4 (4.9-5.9) and 2.7 (2.4-3.0) per 100 person-years, respectively. At 36-months, these decreased to 4.4 (4.2-4.7), 3.5 (3.2-2.7) and 1.4 (1.3-1.6) per 100 person-years, respectively. Over 36-months, the rate of all-cause mortality and major bleeds were highest in patients treated with parenteral therapy (PAR) versus oral anti-coagulants (OAC) and no OAC, and the rate of recurrent VTE was highest in patients on no OAC versus those on PAR and OAC. The most frequent cause of death after 36-month follow-up was cancer (n = 565, 48.6 %), followed by cardiac (n = 94, 8.1 %), and VTE (n = 38, 3.2 %). Most recurrent VTE events were DVT alone (n = 564, 63.3 %), with the remainder PE, (n = 236, 27.3 %), or PE in combination with DVT (n = 63, 7.3 %).Interpretation: GARFIELD-VTE provides a global perspective of anticoagulation patterns and highlights the accumulation of events within the first 12 months after diagnosis. These findings may help identify treatment gaps for subsequent interventions to improve patient outcomes in this patient population.
2023
36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE / Turpie, Alexander G.G.; Farjat, Alfredo E.; Haas, Sylvia; Ageno, Walter; Weitz, Jeffrey I.; Goldhaber, Samuel Z.; Goto, Shinya; Angchaisuksiri, Pantep; Kayani, Gloria; Lopes, Renato D.; Chiang, Chern-En; Gibbs, Harry; Tse, Eric; Verhamme, Peter; ten Cate, Hugo; Muntaner, Juan; Schellong, Sebastian; Bounameaux, Henri; Prandoni, Paolo; Maheshwari, Uma; Kakkar, Ajay K.; Loualidi, Ab; Colak, Abdurrahim; Bezuidenhout, Abraham; Abdool-Carrim, Abu; Azeddine, Addala; Beyers, Adriaan; Dees, Adriaan; Mohamed, Ahmed; Aksoy, Ahmet; Abiko, Akihiko; Watanabe, Akinori; Krichell, Alan; Fernandez, Alberto Alfredo; Tosetto, Alberto; Khotuntsov, Alexey; Oropallo, Alisha; Slocombe, Alison; Kelly, Allan; Clark, Amanda; Gad, Amr; Arouni, Amy; Schmidt, Andor; Berni, Andrea; Kleiban, Andres Javier; Machowski, Andrew; Kazakov, Andrey; Galvez, Angel; Lockman, Ann; Falanga, Anna; Chauhan, Anoop; Riera-Mestre, Antoni; Mazzone, Antonino; D'Angelo, Armando; Herdy, Artur; Kato, Atsushi; Salem, Ayman Abd Elhamid Ebrahim Mahmoud; Husin, Azlan; Erdelyi, Barbara; Jacobson, Barry; Amann-Vesti, Beatrice; Battaloglu, Bektas; Wilson, Benedicte; Cosmi, Benilde; Francois, Bergmann Jean; Toufek, Berremeli; Hunt, Beverley; Natha, Bhavesh; Mustafa, Bisher; Kho, Bonnie Chi Shan; Carine, Boulon; Zidel, Brian; Dominique, Brisot; Christophe, Brousse; Trimarco, Bruno; Luo, Canhua; Cuneo, Carlos Alberto; Diaz, Carlos Jerjes Sanchez; Schwencke, Carsten; Cader, Cas; Yavuz, Celal; Zaidman, Cesar Javier; Lunn, Charles; Wu, Chau-Chung; Toh, Cheng Hock; Chiang, Chern-En; Elisa, Chevrier; Hsia, Chien-Hsun; Huang, Chien-Lung; Kwok, Chi-Hang Kevin; Wu, Chih-Cheng; Huang, Chi-Hung; Ward, Chris; Opitz, Christian; Jeanneret-Gris, Christina; Ha, Chung Yin; Huang, Chun-Yao; Bidi, Claude Luyeye; Smith, Clifford; Brauer, Cornelia; Lodigiani, Corrado; Francis, Couturaud; Wu, Cynthia; Staub, Daniel; Theodoro, Daniel; Poli, Daniela; Acevedo, David - Riesco; Adler, David; Jimenez, David; Keeling, David; Scott, David; Imberti, Davide; Creagh, Desmond; Helene, Desmurs-Clavel; Hagemann, Dirk; Le Roux, Dirk; Skowasch, Dirk; Belenky, Dmitry; Dorokhov, Dmitry; Petrov, Dmitry; Zateyshchikov, Dmitry; Prisco, Domenico; Møller, Dorthe; Kucera, Dusan; Esheiba, Ehab M.; Panchenko, Elizaveta; Dominique, Elkouri; Dogan, Emre; Kubat, Emre; Diaz, Enrique Diaz; Tse, Eric Wai Choi; Yeo, Erik; Hashas, Erman; Grochenig, Ernst; Tiraferri, Eros; Blessing, Erwin; Michèle, Escande Orthlieb; Usandizaga, Esther; Porreca, Ettore; Ferroni, Fabian; Nicolas, Falvo; Ayala-Paredes, Félix; Koura, Firas; Henry, Fitjerald; Cosmi, Franco; Erdkamp, Frans; Kamalov, Gadel; Dalmau, Garcia-Bragado; Damien, Garrigues; Klein, Garry; Shah, Gaurand; Hollanders, Geert; Merli, Geno; Plassmann, Georg; Platt, George; Poirier, Germain; Sokurenko, German; Haddad, Ghassan; Ali, Gholam; Agnelli, Giancarlo; Gan, Gin Gin; Kaye-Eddie, Grace; Le Gal, Gregoire; Allen, Gregory; Esperón, Guillermo Antonio Llamas; Jean-Paul, Guillot; Gerofke, Hagen; Elali, Hallah; Burianova, Hana; Ohler, Hans-Juergen; Wang, Haofu; Darius, Harald; Gogia, Harinder S.; Striekwold, Harry; Gibbs, Harry; Hasanoglu, Hatice; Turker, Hatice; Franow, Hendrik; Bounameaux, Henri; De Raedt, Herbert; Schroe, Herman; ElDin, Hesham Salah; Zidan, Hesham; Nakamura, Hiroaki; Kim, Ho Young; Lawall, Holger; Zhu, Hong; Tian, Hongyan; Yhim, Ho-Young; ten Cate, Hugo; Hwang, Hun Gyu; Shim, Hyeok; Kim, Igor; Libov, Igor; Sonkin, Igor; Suchkov, Igor; Song, Ik-Chan; Kiris, Ilker; Staroverov, Ilya; Looi, Irene; De La Azuela Tenorio, Isabel M.; Savas, Ismail; Gordeev, Ivan; Podpera, Ivo; Lee, Jae Hoon; Sathar, Jameela; Welker, James; Beyer-Westendorf, Jan; Kvasnicka, Jan; Vanwelden, Jan; Kim, JangYong; Svobodova, Jaromira; Gujral, Jaspal; Marino, Javier; Galvar, Javier Tristan; Kassis, Jeannine; Kuo, Jen-Yuan; Shih, Jhih-Yuan; Kwon, JiHyun; Joh, Jin Hyun; Park, Jin Hyun; Kim, Jin Seok; Yang, Jinghua; Krupicka, Jiri; Lastuvka, Jiri; Pumprla, Jiri; Vesely, Jiri; Souto, Joan Carlos; Correa, João Antônio; Duchateau, Johan; Fletcher, John Perry; del Toro, Jorge; del Toro, Jorge; Paez, Jorge Guillermo Chavez; Nielsen, Jørn; Filho, Jose Dalmo Araujo; Saraiva, Jose; Peromingo, Jose Antonio Diaz; Lara, Jose Gomez; Fedele, Jose Luis; Surinach, Jose Maria; Chacko, Joseph; Muntaner, Juan Antonio; Benitez, Juan Carlos Álvarez; Abril, Juan Moreno Hoyos; Humphrey, Julian; Bono, Julio; Kanda, Junji; Boondumrongsagoon, Juree; Yiu, Kai Hang; Chansung, Kanchana; Boomars, Karin; Burbury, Kate; Kondo, Katsuhiro; Karaarslan, Kemal; Takeuchi, Kensuke; Kroeger, Knut; Zrazhevskiy, Konstantin; Svatopluk, Koscál; Shyu, Kou-Gi; Vandenbosch, Kristel; Chang, Kuan-Cheng; Chiu, Kuan-Ming; Jean-Manuel, Kubina; Wern, Kwan Jing; Ueng, Kwo-Chang; Norasetthada, Lalita; Binet, Laure; Chew, Lee Ping; Zhang, Lei; Cristina, Leone Maria; Tick, Lidwine; Schiavi, Lilia Beatriz; Wong, Lily Lee Lee; Borges, Lohana; Botha, Louis; Capiau, Luc; Timmermans, Luc; López, Luciano Eduardo; Ria, Luigi; Blasco, Luis Manuel Hernandez; Guzman, Luis Alberto; Cervera, Luis Flota; Isabelle, Mahe; Bosch, Manuel Monreal; de los Rios Ibarra, Manuel; Fernandez, Manuel Núñez; Carrier, Marc; Barrionuevo, Marcelo Raul; Gamba, Marco Antonio Alcocer; Cattaneo, Marco; Moia, Marco; Bowers, Margaret; Chetanachan, Mariam; Berli, Mario Alberto; Fixley, Mark; Faghih, Markus; Stuecker, Markus; Schul, Marlin; Banyai, Martin; Koretzky, Martin; Myriam, Martin; Gaffney, Mary Elizabeth; Hirano, Masao; Kanemoto, Masashi; Nakamura, Mashio; Tahar, Mersel; Emmanuel, Messas; Kovacs, Michael; Leahy, Michael; Levy, Michael; Munch, Michael; Olsen, Michael; De Pauw, Michel; Gustin, Michel; Van Betsbrugge, Michiel; Boyarkin, Mikhail; Homza, Miroslav; Koto, Modise; Abdool-Gaffar, Mohamed; Nagib, Mohamed Ayman Fakhry; El-Dessoki, Mohamed; Khan, Mohamed; Mohamed, Monniaty; Kim, Moo Hyun; Lee, Moon-Hee; Soliman, Mosaad; Ahmed, Mostafa Shawky; el Bary, Mostafa Soliman Abd; Moustafa, Moustafa A.; Hameed, Muhammad; Kanko, Muhip; Majumder, Mujibur; Zubareva, Nadezhda; Mumoli, Nicola; Abdullah, Nik Azim Nik; Makruasi, Nisa; Paruk, Nishen; Kanitsap, Nonglak; Duda, Norberto; Nordin, Nordiana; Nyvad, Ole; Barbarash, Olga; Gurbuz, Orcun; Vilamajo, Oscar Gomez; Flores, Oscar Nandayapa; Gur, Ozcan; Oto, Oztekin; Marchena, Pablo Javier; Angchaisuksiri, Pantep; Carroll, Patrick; Lang, Pavel; MacCallum, Peter; von Bilderling, Peter Baron; Blombery, Peter; Verhamme, Peter; Jansky, Petr; Bernadette, Peuch; De Vleeschauwer, Philippe; Hainaut, Philippe; Ferrini, Piera Maria; Iamsai, Piriyaporn; Christian, Ponchaux; Viboonjuntra, Pongtep; Rojnuckarin, Ponlapat; Ho, Prahlad; Mutirangura, Pramook; Wells, Rachel; Martinez, Rafael; Miranda, Raimundo Tirado; Kroening, Ralf; Ratsela, Rapule; Reyes, Raquel Lopez; de Leon, Raul Franco Diaz; Wong, Raymond Siu Ming; Alikhan, Raz; Jerwan-Keim, Reinhold; Otero, Remedios; Murena-Schmidt, Renate; Canevascini, Reto; Ferkl, Richard; White, Richard; Van Herreweghe, Rika; Santoro, Rita; Klamroth, Robert; Mendes, Robert; Prosecky, Robert; Cappelli, Roberto; Spacek, Rudolf; Singh, Rupesh; Griffin, Sam; Na, Sang Hoon; Chunilal, Sanjeev; Middeldorp, Saskia; Nakazawa, Satoshi; Schellong, Sebastian; Toh, See Guan; Christophe, Seinturier; Isbir, Selim; Raymundo, Selma; Ting, Seng Kiat; Motte, Serge; Aktogu, Serir Ozkan; Donders, Servaas; Cha, Seung Ick; Nam, Seung-Hyun; Marie-Antoinette, Sevestre-Pietri; Maasdorp, Shaun; Sun, Shenghua; Wang, Shenming; Essameldin, Sherif Mohamed; Sholkamy, Sherif Mohamed; Kuki, Shintaro; Goto, Shinya; Yoshida, Shuichi; Matsuoka, Shunzo; McRae, Simon; Watt, Simon; Patanasing, Siriwimon; Jean-Léopold, Siwe-Nana; Wongkhantee, Somchai; Bang, Soo-Mee; Testa, Sophie; Zemek, Stanislav; Behrens, Steffen; Dominique, Stephan; Mellor, Stuart; Singh, Suaran Singh Gurcharan; Datta, Sudip; Chayangsu, Sunee; Solymoss, Susan; Everington, Tamara; Abdel-Azim, Tarek Ahmed Adel; Suwanban, Tawatchai; Adademir, Taylan; Hart, Terence; Béatrice, Terriat; Luvhengo, Thifhelimbilu; Horacek, Thomas; Zeller, Thomas; Boussy, Tim; Reynolds, Tim; Biss, Tina; Chao, Ting-Hsing; Casabella, Tomas Smith; Onodera, Tomoya; Numbenjapon, Tontanai; Gerdes, Victor; Cech, Vladimir; Krasavin, Vladimir; Tolstikhin, Vladimir; Bax, W.A.; Malek, Wagih Fawzy Abdel; Ho, Wai Khoon; Ageno, Walter; Pharr, Walter; Jiang, Weihong; Lin, Wei-Hsiang; Zhang, Weihua; Tseng, Wei-Kung; Lai, Wen-Ter; De Backer, Wilfried; Haverkamp, Wilhelm; Yoshida, Winston; Korte, Wolfgang; Choi, Won Il; Kim, Yang-Ki; Tanabe, Yasuhiro; Ohnuma, Yasushi; Mun, Yeung-Chul; Balthazar, Yohan; Park, Yong; Shibata, Yoshisato; Burov, Yuriy; Subbotin, Yuriy; Coufal, Zdenek; Yang, Zhenwen; Jing, Zhicheng; Jing, Zhicheng; Yang, Zhongqi. - In: THROMBOSIS RESEARCH. - ISSN 0049-3848. - STAMPA. - 222:(2023), pp. 31-39. [10.1016/j.thromres.2022.11.016]
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