Alzheimer's disease (AD) represents the most prevalent type of dementia in elderly people, primarily characterized by brain accumulation of beta-amyloid (A beta) peptides, derived from Amyloid Precursor Protein (APP), in the extracellular space (amyloid plaques) and intracellular deposits of the hyperphosphorylated form of the protein tau (p-tau; tangles or neurofibrillary aggregates). The Nerve growth factor receptor (NGFR/p75(NTR)) represents a low-affinity receptor for all known mammalians neurotrophins (i.e., proNGF, NGF, BDNF, NT-3 e NT-4/5) and it is involved in pathways that determine both survival and death of neurons. Interestingly, also A beta peptides can blind to NGFR/p75(NTR) making it the "ideal" candidate in mediating A beta-induced neuropathology. In addition to pathogenesis and neuropathology, several data indicated that NGFR/p75(NTR) could play a key role in AD also from a genetic perspective. Other studies suggested that NGFR/p75(NTR) could represent a good diagnostic tool, as well as a promising therapeutic target for AD. Here, we comprehensively summarize and review the current experimental evidence on this topic.
The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer’s Disease / Bruno, Francesco; Abondio, Paolo; Montesanto, Alberto; Luiselli, Donata; Bruni, Amalia C.; Maletta, Raffaele. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - ELETTRONICO. - 24:4(2023), pp. 3200.1-3200.13. [10.3390/ijms24043200]
The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer’s Disease
Abondio, Paolo
Secondo
;Luiselli, Donata;
2023
Abstract
Alzheimer's disease (AD) represents the most prevalent type of dementia in elderly people, primarily characterized by brain accumulation of beta-amyloid (A beta) peptides, derived from Amyloid Precursor Protein (APP), in the extracellular space (amyloid plaques) and intracellular deposits of the hyperphosphorylated form of the protein tau (p-tau; tangles or neurofibrillary aggregates). The Nerve growth factor receptor (NGFR/p75(NTR)) represents a low-affinity receptor for all known mammalians neurotrophins (i.e., proNGF, NGF, BDNF, NT-3 e NT-4/5) and it is involved in pathways that determine both survival and death of neurons. Interestingly, also A beta peptides can blind to NGFR/p75(NTR) making it the "ideal" candidate in mediating A beta-induced neuropathology. In addition to pathogenesis and neuropathology, several data indicated that NGFR/p75(NTR) could play a key role in AD also from a genetic perspective. Other studies suggested that NGFR/p75(NTR) could represent a good diagnostic tool, as well as a promising therapeutic target for AD. Here, we comprehensively summarize and review the current experimental evidence on this topic.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.