Alzheimer's disease (AD) represents the most prevalent type of dementia in elderly people, primarily characterized by brain accumulation of beta-amyloid (A beta) peptides, derived from Amyloid Precursor Protein (APP), in the extracellular space (amyloid plaques) and intracellular deposits of the hyperphosphorylated form of the protein tau (p-tau; tangles or neurofibrillary aggregates). The Nerve growth factor receptor (NGFR/p75(NTR)) represents a low-affinity receptor for all known mammalians neurotrophins (i.e., proNGF, NGF, BDNF, NT-3 e NT-4/5) and it is involved in pathways that determine both survival and death of neurons. Interestingly, also A beta peptides can blind to NGFR/p75(NTR) making it the "ideal" candidate in mediating A beta-induced neuropathology. In addition to pathogenesis and neuropathology, several data indicated that NGFR/p75(NTR) could play a key role in AD also from a genetic perspective. Other studies suggested that NGFR/p75(NTR) could represent a good diagnostic tool, as well as a promising therapeutic target for AD. Here, we comprehensively summarize and review the current experimental evidence on this topic.
Bruno, F., Abondio, P., Montesanto, A., Luiselli, D., Bruni, A.C., Maletta, R. (2023). The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer’s Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(4), 1-13 [10.3390/ijms24043200].
The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer’s Disease
Abondio, Paolo
Secondo
;Luiselli, Donata;
2023
Abstract
Alzheimer's disease (AD) represents the most prevalent type of dementia in elderly people, primarily characterized by brain accumulation of beta-amyloid (A beta) peptides, derived from Amyloid Precursor Protein (APP), in the extracellular space (amyloid plaques) and intracellular deposits of the hyperphosphorylated form of the protein tau (p-tau; tangles or neurofibrillary aggregates). The Nerve growth factor receptor (NGFR/p75(NTR)) represents a low-affinity receptor for all known mammalians neurotrophins (i.e., proNGF, NGF, BDNF, NT-3 e NT-4/5) and it is involved in pathways that determine both survival and death of neurons. Interestingly, also A beta peptides can blind to NGFR/p75(NTR) making it the "ideal" candidate in mediating A beta-induced neuropathology. In addition to pathogenesis and neuropathology, several data indicated that NGFR/p75(NTR) could play a key role in AD also from a genetic perspective. Other studies suggested that NGFR/p75(NTR) could represent a good diagnostic tool, as well as a promising therapeutic target for AD. Here, we comprehensively summarize and review the current experimental evidence on this topic.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
