Autosomal polycystic kidney disease is the most common inherited kidney disease determining 5% of all end-stage kidney disease. The only therapy approved for this condition is Tolvaptan, which, with its aquaretic effect, has a strong effect on patients’ daily life. Recently, the literature has been enriched with new works that analyze possible non-pharmacological therapeutic strategies to slow cysts’ enlargement and chronic kidney disease progression. Among them, dietary schemes reducing carbohydrate intake and inducing ketoses have been demonstrated to have efficacy in several pre-clinical and clinical studies. A ketogenic diet, calorie restriction, intermittent fasting, and time-restricted feeding can reduce aerobic glycolysis and inhibit the mTOR pathway, producing a reduction in cyst cell proliferation, a reduction in kidney volume, and helping to preserve kidney function. ADPKD’s burden of disease has an impact on patients’ quality of life, and the possibility to play sports or carry out physical exercise can help people in everyday life. The multisystemic character of the disease, especially cardiovascular involvement, needs to be carefully evaluated to establish the quality and quantity of physical activity that patients can safely carry out.

Capelli I., Lerario S., Aiello V., Provenzano M., Di Costanzo R., Squadrani A., et al. (2023). Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature. NUTRIENTS, 15(11), 1-15 [10.3390/nu15112621].

Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature

Capelli I.
Primo
;
Lerario S.;Provenzano M.;Di Costanzo R.;Vella A.;Vicennati V.;La Manna G.
;
Baraldi O.
Ultimo
2023

Abstract

Autosomal polycystic kidney disease is the most common inherited kidney disease determining 5% of all end-stage kidney disease. The only therapy approved for this condition is Tolvaptan, which, with its aquaretic effect, has a strong effect on patients’ daily life. Recently, the literature has been enriched with new works that analyze possible non-pharmacological therapeutic strategies to slow cysts’ enlargement and chronic kidney disease progression. Among them, dietary schemes reducing carbohydrate intake and inducing ketoses have been demonstrated to have efficacy in several pre-clinical and clinical studies. A ketogenic diet, calorie restriction, intermittent fasting, and time-restricted feeding can reduce aerobic glycolysis and inhibit the mTOR pathway, producing a reduction in cyst cell proliferation, a reduction in kidney volume, and helping to preserve kidney function. ADPKD’s burden of disease has an impact on patients’ quality of life, and the possibility to play sports or carry out physical exercise can help people in everyday life. The multisystemic character of the disease, especially cardiovascular involvement, needs to be carefully evaluated to establish the quality and quantity of physical activity that patients can safely carry out.
2023
Capelli I., Lerario S., Aiello V., Provenzano M., Di Costanzo R., Squadrani A., et al. (2023). Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature. NUTRIENTS, 15(11), 1-15 [10.3390/nu15112621].
Capelli I.; Lerario S.; Aiello V.; Provenzano M.; Di Costanzo R.; Squadrani A.; Vella A.; Vicennati V.; Poli C.; La Manna G.; Baraldi O.
File in questo prodotto:
File Dimensione Formato  
nutrients-15-02621.pdf

accesso aperto

Descrizione: Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature
Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY)
Dimensione 773.84 kB
Formato Adobe PDF
773.84 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/962638
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 5
social impact