Although most patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) experience respiratory manifestations, multi-organ dysfunction is frequent. Almost 20% of hospitalized patients with SARS-CoV-2 infection develop acute kidney injury (AKI). The pathophysiology of AKI is a result of both the direct and indirect effects of SARS-CoV-2 infection, including systemic inflammatory responses, the activation of the renin-angiotensin-aldosterone system (RAAS), and endothelial and coagulative dysfunction. Underlying SARS-CoV-2 infection-associated AKI, an immunological hyper-response with an unbalanced innate and adaptative response defined as a “cytokine storm” has emerged. Numerous agents have been tested in an effort to mitigate the cytokine storm, and a range of extracorporeal cytokine removal techniques have been proposed as potential therapeutic options. In the present review, we summarize the main pathogenetic mechanisms underlying COVID-19-related AKI in order to provide an appropriate individual therapeutic strategy to improve clinical outcomes and limit the progression of early disease.

Acute Kidney Injury and Blood Purification Techniques in Severe COVID-19 Patients / Napoli M.; Provenzano M.; Hu L.; Bini C.; Abenavoli C.; La Manna G.; Comai G.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - ELETTRONICO. - 11:21(2022), pp. 6286.1-6286.17. [10.3390/jcm11216286]

Acute Kidney Injury and Blood Purification Techniques in Severe COVID-19 Patients

Provenzano M.;Hu L.;Bini C.;Abenavoli C.;La Manna G.
;
Comai G.
Ultimo
2022

Abstract

Although most patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) experience respiratory manifestations, multi-organ dysfunction is frequent. Almost 20% of hospitalized patients with SARS-CoV-2 infection develop acute kidney injury (AKI). The pathophysiology of AKI is a result of both the direct and indirect effects of SARS-CoV-2 infection, including systemic inflammatory responses, the activation of the renin-angiotensin-aldosterone system (RAAS), and endothelial and coagulative dysfunction. Underlying SARS-CoV-2 infection-associated AKI, an immunological hyper-response with an unbalanced innate and adaptative response defined as a “cytokine storm” has emerged. Numerous agents have been tested in an effort to mitigate the cytokine storm, and a range of extracorporeal cytokine removal techniques have been proposed as potential therapeutic options. In the present review, we summarize the main pathogenetic mechanisms underlying COVID-19-related AKI in order to provide an appropriate individual therapeutic strategy to improve clinical outcomes and limit the progression of early disease.
2022
Acute Kidney Injury and Blood Purification Techniques in Severe COVID-19 Patients / Napoli M.; Provenzano M.; Hu L.; Bini C.; Abenavoli C.; La Manna G.; Comai G.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - ELETTRONICO. - 11:21(2022), pp. 6286.1-6286.17. [10.3390/jcm11216286]
Napoli M.; Provenzano M.; Hu L.; Bini C.; Abenavoli C.; La Manna G.; Comai G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/962504
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